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The Role of Polygenic Susceptibility on Air Pollution-Associated Asthma between German and Japanese Elderly Women

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  • Sara Kress

    (IUF—Leibniz Research Institute for Environmental Medicine, Auf’m Hennekamp 50, 40225 Düsseldorf, Germany
    Medical Research School Düsseldorf, Heinrich Heine University, Universitätsstraße 1, 40225 Düsseldorf, Germany)

  • Akinori Hara

    (Department of Hygiene and Public Health, Graduate School of Advanced Preventive Medical Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa 920-8640, Ishikawa, Japan)

  • Claudia Wigmann

    (IUF—Leibniz Research Institute for Environmental Medicine, Auf’m Hennekamp 50, 40225 Düsseldorf, Germany)

  • Takehiro Sato

    (Department of Bioinformatics and Genomics, Graduate School of Advanced Preventive Medical Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa 920-8640, Ishikawa, Japan)

  • Keita Suzuki

    (Department of Hygiene and Public Health, Graduate School of Advanced Preventive Medical Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa 920-8640, Ishikawa, Japan)

  • Kim-Oanh Pham

    (Department of Hygiene and Public Health, Graduate School of Advanced Preventive Medical Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa 920-8640, Ishikawa, Japan)

  • Qi Zhao

    (IUF—Leibniz Research Institute for Environmental Medicine, Auf’m Hennekamp 50, 40225 Düsseldorf, Germany
    Department of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong University, 44 West Wenhua Road, Jinan 250012, China)

  • Ashtyn Areal

    (IUF—Leibniz Research Institute for Environmental Medicine, Auf’m Hennekamp 50, 40225 Düsseldorf, Germany
    Medical Research School Düsseldorf, Heinrich Heine University, Universitätsstraße 1, 40225 Düsseldorf, Germany)

  • Atsushi Tajima

    (Department of Bioinformatics and Genomics, Graduate School of Advanced Preventive Medical Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa 920-8640, Ishikawa, Japan)

  • Holger Schwender

    (Mathematical Institute, Heinrich Heine University, Universitätsstraße 1, 40225 Düsseldorf, Germany)

  • Hiroyuki Nakamura

    (Department of Hygiene and Public Health, Graduate School of Advanced Preventive Medical Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa 920-8640, Ishikawa, Japan
    These authors contributed equally to this work.)

  • Tamara Schikowski

    (IUF—Leibniz Research Institute for Environmental Medicine, Auf’m Hennekamp 50, 40225 Düsseldorf, Germany
    These authors contributed equally to this work.)

Abstract

Polygenic susceptibility likely influences individual responses to air pollutants and the risk of asthma. We compared the role of polygenic susceptibility on air pollution-associated asthma between German and Japanese women. We investigated women that were enrolled in the German SALIA cohort (n = 771, mean age = 73 years) and the Japanese Shika cohort (n = 847, mean age = 67 years) with known asthma status. Adjusted logistic regression models were used to assess the associations between (1) particulate matter with a median aerodynamic diameter ≤ 2.5μm (PM 2.5 ) and nitrogen dioxide (NO 2 ), (2) polygenic risk scores (PRS), and (3) gene-environment interactions (G × E) with asthma. We found an increased risk of asthma in Japanese women after exposure to low pollutant levels (PM 2.5 : median = 12.7µg/m 3 , p -value < 0.001, NO 2 : median = 8.5µg/m 3 , p -value < 0.001) and in German women protective polygenic effects ( p -value = 0.008). While we found no significant G × E effects, the direction in both groups was that the PRS increased the effect of PM 2.5 and decreased the effect of NO 2 on asthma. Our study confirms that exposure to low air pollution levels increases the risk of asthma in Japanese women and indicates polygenic effects in German women; however, there was no evidence of G × E effects. Future genome-wide G × E studies should further explore the role of ethnic-specific polygenic susceptibility to asthma.

Suggested Citation

  • Sara Kress & Akinori Hara & Claudia Wigmann & Takehiro Sato & Keita Suzuki & Kim-Oanh Pham & Qi Zhao & Ashtyn Areal & Atsushi Tajima & Holger Schwender & Hiroyuki Nakamura & Tamara Schikowski, 2022. "The Role of Polygenic Susceptibility on Air Pollution-Associated Asthma between German and Japanese Elderly Women," IJERPH, MDPI, vol. 19(16), pages 1-11, August.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:16:p:9869-:d:884986
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    References listed on IDEAS

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    1. Shuang Song & Wei Jiang & Lin Hou & Hongyu Zhao, 2020. "Leveraging effect size distributions to improve polygenic risk scores derived from summary statistics of genome-wide association studies," PLOS Computational Biology, Public Library of Science, vol. 16(2), pages 1-18, February.
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