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Feasibility and Acceptability of Personalized Breast Cancer Screening (DECIDO Study): A Single-Arm Proof-of-Concept Trial

Author

Listed:
  • Celmira Laza-Vásquez

    (Department of Nursing and Physiotherapy and Health Care Research Group (GRECS), IRBLleida—Institut de Recerca Biomèdica de Lleida, University of Lleida, 25198 Lleida, Spain)

  • Montserrat Martínez-Alonso

    (IRBLleida—Institut de Recerca Biomèdica de Lleida, Department of Basic Medical Sciences, University of Lleida, 25198 Lleida, Spain)

  • Carles Forné-Izquierdo

    (Department of Basic Medical Sciences, University of Lleida, 25198 Lleida, Spain
    Heorfy Consulting, 25007 Lleida, Spain)

  • Jordi Vilaplana-Mayoral

    (Department of Computing and Industrial Engineering, University of Lleida, 25001 Lleida, Spain)

  • Inés Cruz-Esteve

    (Primer de Maig Basic Health Area, Catalan Institute of Health, 25003 Lleida, Spain)

  • Isabel Sánchez-López

    (Proteomics and Genomics Service, University of Lleida, 25198 Lleida, Spain)

  • Mercè Reñé-Reñé

    (Department of Radiology, Arnau de Vilanova University Hospital, 25198 Lleida, Spain)

  • Cristina Cazorla-Sánchez

    (Primer de Maig Basic Health Area, Catalan Institute of Health, 25003 Lleida, Spain)

  • Marta Hernández-Andreu

    (Primer de Maig Basic Health Area, Catalan Institute of Health, 25003 Lleida, Spain)

  • Gisela Galindo-Ortego

    (Primer de Maig Basic Health Area, Catalan Institute of Health, 25003 Lleida, Spain)

  • Montserrat Llorens-Gabandé

    (Breast Cancer Screening Program, Catalan Institute of Health, 25006 Lleida, Spain)

  • Anna Pons-Rodríguez

    (Example Basic Health Area, Catalan Institute of Health, 25006 Lleida, Spain
    Health PhD Program, University of Lleida, 25198 Lleida, Spain)

  • Montserrat Rué

    (IRBLleida—Institut de Recerca Biomèdica de Lleida, Department of Basic Medical Sciences, University of Lleida, 25198 Lleida, Spain)

Abstract

The aim of this study was to assess the acceptability and feasibility of offering risk-based breast cancer screening and its integration into regular clinical practice. A single-arm proof-of-concept trial was conducted with a sample of 387 women aged 40–50 years residing in the city of Lleida (Spain). The study intervention consisted of breast cancer risk estimation, risk communication and screening recommendations, and a follow-up. A polygenic risk score with 83 single nucleotide polymorphisms was used to update the Breast Cancer Surveillance Consortium risk model and estimate the 5-year absolute risk of breast cancer. The women expressed a positive attitude towards varying the frequency of breast screening according to individual risk and, especially, more frequently inviting women at higher-than-average risk. A lower intensity screening for women at lower risk was not as welcome, although half of the participants would accept it. Knowledge of the benefits and harms of breast screening was low, especially with regard to false positives and overdiagnosis. The women expressed a high understanding of individual risk and screening recommendations. The participants’ intention to participate in risk-based screening and satisfaction at 1-year were very high.

Suggested Citation

  • Celmira Laza-Vásquez & Montserrat Martínez-Alonso & Carles Forné-Izquierdo & Jordi Vilaplana-Mayoral & Inés Cruz-Esteve & Isabel Sánchez-López & Mercè Reñé-Reñé & Cristina Cazorla-Sánchez & Marta Hern, 2022. "Feasibility and Acceptability of Personalized Breast Cancer Screening (DECIDO Study): A Single-Arm Proof-of-Concept Trial," IJERPH, MDPI, vol. 19(16), pages 1-22, August.
  • Handle: RePEc:gam:jijerp:v:19:y:2022:i:16:p:10426-:d:894106
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    References listed on IDEAS

    as
    1. Celmira Laza-Vásquez & María José Hernández-Leal & Misericòrdia Carles-Lavila & Maria José Pérez-Lacasta & Inés Cruz-Esteve & Montserrat Rué & on behalf of the DECIDO Group, 2022. "Barriers and Facilitators to the Implementation of a Personalized Breast Cancer Screening Program: Views of Spanish Health Professionals," IJERPH, MDPI, vol. 19(3), pages 1-16, January.
    2. Nikolai Mühlberger & Gaby Sroczynski & Artemisa Gogollari & Beate Jahn & Nora Pashayan & Ewout Steyerberg & Martin Widschwendter & Uwe Siebert, 2021. "Cost effectiveness of breast cancer screening and prevention: a systematic review with a focus on risk-adapted strategies," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 22(8), pages 1311-1344, November.
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