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Oral Lesions Following Anti-SARS-CoV-2 Vaccination: A Systematic Review

Author

Listed:
  • Federica Di Spirito

    (Department of Medicine, Surgery and Dentistry, University of Salerno, 84084 Salerno, Italy)

  • Alessandra Amato

    (Department of Neuroscience, Reproductive Science and Dentistry, University of Naples Federico II, 80138 Naples, Italy)

  • Maria Pia Di Palo

    (Department of Medicine, Surgery and Dentistry, University of Salerno, 84084 Salerno, Italy)

  • Maria Contaldo

    (Multidisciplinary Department of Medical-Surgical and Odontostomatological Specialities, University of Campania “Luigi Vanvitelli”, 81100 Naples, Italy)

  • Francesco D’Ambrosio

    (Department of Medicine, Surgery and Dentistry, University of Salerno, 84084 Salerno, Italy)

  • Roberto Lo Giudice

    (Department of Human Pathology in Adulthood and Childhood “G. Barresi”, University Hospital “G. Martino” of Messina, Via Consolare Valeria 1, 98123 Messina, Italy)

  • Massimo Amato

    (Department of Medicine, Surgery and Dentistry, University of Salerno, 84084 Salerno, Italy)

Abstract

Increasing evidence relate anti-SARS-CoV-2 vaccinations to orofacial adverse reactions, therefore, the present systematic review aimed to evaluate primary oral lesions diagnosed in adult subjects, following the WHO Emergency Use Listing approved and EMA authorized vaccines, also in relation to cases’ age, gender, comorbidities, and history of COVID-19, and in relation to vaccine type and doses. The study protocol, registered on PROSPERO (CRD42022339032) and compliant with the PRISMA statement, included an electronic search across Scopus, MEDLINE/PubMed, BioMed Central databases, and PROSPERO, ended on 18 June 2022 and succeeded by a manual search, an independent data extraction, and arisk of bias evaluation through ROBINS-I tool. Qualitatively synthesized data from the 13studies included showed an overall low prevalence (16 cases), though higher in females (68.8%), of oral lesions, mainly erosions and ulcers (34.5%). Nine cases were diagnosed following Pfizer-BioNTech, two Moderna, and one AstraZeneca, Serum Institute of India, Sinopharm, and Johnson&Johnson vaccines, respectively; specifically, eight after the first dose and seven after the second. In one case, vaccine type and dose were not specified. Considering newly developing vaccines, presented findings may be updated and further studies needed to highlight factors affecting oral lesion occurrence and specific macro-microscopic phenotypes in relation to cases’ and vaccines’ characteristics.

Suggested Citation

  • Federica Di Spirito & Alessandra Amato & Maria Pia Di Palo & Maria Contaldo & Francesco D’Ambrosio & Roberto Lo Giudice & Massimo Amato, 2022. "Oral Lesions Following Anti-SARS-CoV-2 Vaccination: A Systematic Review," IJERPH, MDPI, vol. 19(16), pages 1-18, August.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:16:p:10228-:d:890772
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    References listed on IDEAS

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    1. Giulia Orilisi & Marco Mascitti & Lucrezia Togni & Riccardo Monterubbianesi & Vincenzo Tosco & Flavia Vitiello & Andrea Santarelli & Angelo Putignano & Giovanna Orsini, 2021. "Oral Manifestations of COVID-19 in Hospitalized Patients: A Systematic Review," IJERPH, MDPI, vol. 18(23), pages 1-19, November.
    2. Alessandro Liberati & Douglas G Altman & Jennifer Tetzlaff & Cynthia Mulrow & Peter C Gøtzsche & John P A Ioannidis & Mike Clarke & P J Devereaux & Jos Kleijnen & David Moher, 2009. "The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-28, July.
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    4. Roberta Gasparro & Cristiano Scandurra & Nelson Mauro Maldonato & Pasquale Dolce & Vincenzo Bochicchio & Alessandra Valletta & Gilberto Sammartino & Pasquale Sammartino & Mauro Mariniello & Alessandro, 2020. "Perceived Job Insecurity and Depressive Symptoms among Italian Dentists: The Moderating Role of Fear of COVID-19," IJERPH, MDPI, vol. 17(15), pages 1-12, July.
    5. Marta Mazur & Irena Duś-Ilnicka & Maciej Jedliński & Artnora Ndokaj & Joanna Janiszewska-Olszowska & Roman Ardan & Malgorzata Radwan-Oczko & Fabrizio Guerra & Valeria Luzzi & Iole Vozza & Roberto Mara, 2021. "Facial and Oral Manifestations Following COVID-19 Vaccination: A Survey-Based Study and a First Perspective," IJERPH, MDPI, vol. 18(9), pages 1-11, May.
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    1. Federica Di Spirito & Alessandra Amato & Francesco D’Ambrosio & Davide Cannatà & Maria Pia Di Palo & Nicoletta Coppola & Massimo Amato, 2023. "HPV-Related Oral Lesions: YouTube Videos Suitability for Preventive Interventions including Mass-Reach Health Communication and Promotion of HPV Vaccination," IJERPH, MDPI, vol. 20(11), pages 1-19, May.
    2. Kelvin I. Afrashtehfar & Carlos A. Jurado & Salem H. Abu-Fanas & Mohamed A. Jaber, 2023. "Health and Well-Being through COVID-19 Vaccination: Physical, Oral, and Psychological Effects," IJERPH, MDPI, vol. 20(4), pages 1-4, February.
    3. Maria Contaldo & Francesco D’Ambrosio & Giuseppe A. Ferraro & Dario Di Stasio & Maria Pia Di Palo & Rosario Serpico & Michele Simeone, 2023. "Antibiotics in Dentistry: A Narrative Review of the Evidence beyond the Myth," IJERPH, MDPI, vol. 20(11), pages 1-31, June.

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