IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v19y2022i15p9398-d877284.html
   My bibliography  Save this article

The Effect of Global Warming on Complex Disorders (Mental Disorders, Primary Hypertension, and Type 2 Diabetes)

Author

Listed:
  • Sarya Natur

    (Department of Clinical Biochemistry and Pharmacology and Psychiatry Research Unit, Faculty of Health Sciences and the Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel)

  • Odeya Damri

    (Department of Clinical Biochemistry and Pharmacology and Psychiatry Research Unit, Faculty of Health Sciences and the Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel)

  • Galila Agam

    (Department of Clinical Biochemistry and Pharmacology and Psychiatry Research Unit, Faculty of Health Sciences and the Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel)

Abstract

Multiple studies imply a strong relationship between global warming (GW) and complex disorders. This review summarizes such reports concentrating on three disorders—mental disorders (MD), primary hypertension, and type 2 diabetes (T2D). We also attempt to point at potential mechanisms mediating the effect of GW on these disorders. Concerning mental disorders, immediate candidates are brain levels of heat-shock proteins (HSPs). In addition, given that heat stress increases reactive oxygen species (ROS) levels which may lead to blood–brain barrier (BBB) breakdown and, hence, enhanced protein extravasation in the brain, this might finally cause, or exacerbate mental health. As for hypertension, since its causes are incompletely understood, the mechanism(s) by which heat exposure affects blood pressure (BP) is an open question. Since the kidneys participate in regulating blood volume and BP they are considered as a site of heat-associated disease, hence, we discuss hyperosmolarity as a potential mediator. In addition, we relate to autoimmunity, inflammation, sodium excretion, and HSP70 as risk factors that might play a role in the effect of heat on hypertension. In the case of T2D, we raise two potential mediators of the effect of exposure to ambient hot environment on the disease’s incidence—brown adipose tissue metabolism and HSPs.

Suggested Citation

  • Sarya Natur & Odeya Damri & Galila Agam, 2022. "The Effect of Global Warming on Complex Disorders (Mental Disorders, Primary Hypertension, and Type 2 Diabetes)," IJERPH, MDPI, vol. 19(15), pages 1-9, July.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:15:p:9398-:d:877284
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/19/15/9398/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/19/15/9398/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Helen Berry & Kathryn Bowen & Tord Kjellstrom, 2010. "Climate change and mental health: a causal pathways framework," International Journal of Public Health, Springer;Swiss School of Public Health (SSPH+), vol. 55(2), pages 123-132, April.
    2. Anja Stotz & Kilian Rapp & Juha Oksa & Dawn A. Skelton & Nina Beyer & Jochen Klenk & Clemens Becker & Ulrich Lindemann, 2014. "Effect of a Brief Heat Exposure on Blood Pressure and Physical Performance of Older Women Living in the Community—A Pilot-Study," IJERPH, MDPI, vol. 11(12), pages 1-9, December.
    3. Xerxes T. Seposo & Tran Ngoc Dang & Yasushi Honda, 2017. "How Does Ambient Air Temperature Affect Diabetes Mortality in Tropical Cities?," IJERPH, MDPI, vol. 14(4), pages 1-10, April.
    4. Mullins, Jamie T. & White, Corey, 2019. "Temperature and mental health: Evidence from the spectrum of mental health outcomes," Journal of Health Economics, Elsevier, vol. 68(C).
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Frijters, Paul & Johnston, David W. & Knott, Rachel & Torgler, Benno, 2021. "Resilience to Disaster: Evidence from Daily Wellbeing Data," IZA Discussion Papers 14220, Institute of Labor Economics (IZA).
    2. Richard Freund, 2023. "From drought to distress: unpacking the mental health effects of water scarcity," CSAE Working Paper Series 2023-07, Centre for the Study of African Economies, University of Oxford.
    3. Meierrieks, Daniel, 2021. "Weather shocks, climate change and human health," World Development, Elsevier, vol. 138(C).
    4. Qiang Wen & Haiqiang Liu & Jinyuan Chen & Huiyao Ye & Zeyu Pan, 2023. "Evaluation of Satisfaction with the Built Environment of University Buildings under the Epidemic and Its Impact on Student Anxiety," IJERPH, MDPI, vol. 20(5), pages 1-23, February.
    5. Raissa Sorgho & Isabel Mank & Moubassira Kagoné & Aurélia Souares & Ina Danquah & Rainer Sauerborn, 2020. "“We Will Always Ask Ourselves the Question of How to Feed the Family”: Subsistence Farmers’ Perceptions on Adaptation to Climate Change in Burkina Faso," IJERPH, MDPI, vol. 17(19), pages 1-25, October.
    6. Wang, Meng & Zhang, Shiying, 2024. "High temperatures and traffic accident crimes: Evidence from more than 470,000 offenses in China," Economics & Human Biology, Elsevier, vol. 55(C).
    7. Nkabinde, B & Lekhanya, L.M & Dorasamy, N., 2024. "Rural-Urban Migration Challenges in South Africa: Case of Kwazulu-Natal (SA)," Journal of Economic and Social Development, Clinical Journals Press, vol. 11(02), pages 01-17, September.
    8. Yan Chen & Xiaohong Chen & Hongshan Ai & Xiaoqing Tan, 2022. "Temperature and Migration Intention: Evidence from the Unified National Graduate Entrance Examination in China," IJERPH, MDPI, vol. 19(16), pages 1-23, August.
    9. Catarina Midões & Enrica De Cian, 2025. "Heat and well-being in the Old Continent," Working Papers 2025: 03, Department of Economics, University of Venice "Ca' Foscari".
    10. Díaz, Juan-José & Saldarriaga, Victor, 2023. "A drop of love? Rainfall shocks and spousal abuse: Evidence from rural Peru," Journal of Health Economics, Elsevier, vol. 89(C).
    11. Sahoo, Dukhabandhu & Mohanty, Pritisudha & Mishra, Surbhi & Behera, Manash & Mohapatra, Souryabrata, 2024. "Does climate-smart agriculture technology improve the subjective well-being of farmers? Evidence from micro-level data," MPRA Paper 123955, University Library of Munich, Germany.
    12. Jamie Mullins & Corey White, 2019. "Does Access to Health Care Mitigate Environmental Damages?," Working Papers 1905, California Polytechnic State University, Department of Economics.
    13. Xuena Liu & Hui Liu & Hua Fan & Yizhi Liu & Guoyong Ding, 2018. "Influence of Heat Waves on Daily Hospital Visits for Mental Illness in Jinan, China—A Case-Crossover Study," IJERPH, MDPI, vol. 16(1), pages 1-11, December.
    14. Min-Liang Chu & Chiao-Yu Shih & Tsung-Cheng Hsieh & Han-Lin Chen & Chih-Wei Lee & Jen-Che Hsieh, 2019. "Acute Myocardial Infarction Hospitalizations between Cold and Hot Seasons in an Island across Tropical and Subtropical Climate Zones—A Population-Based Study," IJERPH, MDPI, vol. 16(15), pages 1-14, August.
    15. Cosaert, Sam & Nieto Castro, Adrian & Tatsiramos, Konstantinos, 2023. "Temperature and the Timing of Work," IZA Discussion Papers 16480, Institute of Labor Economics (IZA).
    16. Hans Sanderson & Michael Goodsite, 2015. "Editorial—Global Climate Change and Contaminants," IJERPH, MDPI, vol. 12(7), pages 1-3, July.
    17. Zac Coates & Michelle Kelly & Scott Brown, 2024. "The Relationship between Climate Anxiety and Pro-Environment Behaviours," Sustainability, MDPI, vol. 16(12), pages 1-14, June.
    18. Ghasem Toloo & Gerard FitzGerald & Peter Aitken & Kenneth Verrall & Shilu Tong, 2013. "Evaluating the effectiveness of heat warning systems: systematic review of epidemiological evidence," International Journal of Public Health, Springer;Swiss School of Public Health (SSPH+), vol. 58(5), pages 667-681, October.
    19. Picchio, Matteo & van Ours, Jan C., 2024. "The impact of high temperatures on performance in work-related activities," Labour Economics, Elsevier, vol. 87(C).
    20. Kathryn J. Bowen & Sharon Friel & Kristie Ebi & Colin D. Butler & Fiona Miller & Anthony J. McMichael, 2011. "Governing for a Healthy Population: Towards an Understanding of How Decision-Making Will Determine Our Global Health in a Changing Climate," IJERPH, MDPI, vol. 9(1), pages 1-18, December.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:19:y:2022:i:15:p:9398-:d:877284. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.