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Night Shift Work Is Associated with Reduced Rate of Humoral Response Following Vaccination for HBV

Author

Listed:
  • Luca Coppeta

    (Department of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy)

  • Cristiana Ferrari

    (School of Occupational Medicine, University of Rome Tor Vergata, 00133 Rome, Italy)

  • Marco Trabucco Aurilio

    (Department of Medicine and Health Sciences “V. Tiberio”, University of Molise, 86100 Campobasso, Italy)

  • Gianluigi Ferrazza

    (Department of System Medicine, University of Rome Tor Vergata, 00133 Rome, Italy)

  • Andrea Magrini

    (Department of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy)

  • Stefano Rizza

    (Department of System Medicine, University of Rome Tor Vergata, 00133 Rome, Italy)

Abstract

Night shift work has been associated with cardiovascular and metabolic disease, endocrine and immunological disorders. Published studies have reported that a reduced total sleep time with sleep-wake cycle alterations were associated with a reduced rate of humoral response following vaccination. Our study aimed to evaluate the association between night shift work and serological status for HBV among workers employed in a university hospital in Rome. We evaluated medical records of 986 HCWs working at Tor Vergata Policlinic of Rome. We screened all study subjects for anti-HBs IgG, anti-HBc IgG and HBsAg. Serological protection for HBV was evaluated in relation to sex, age group, job task, risk setting and night shift work status. Protective titer was found in 856 (86.8%) study participants and the mean titer was significantly high in females, in subjects aged less than 40 years, in night shift workers and in high-risk setting workers. After adjustment for study covariates, night shift work was no longer associated with an HBV-protective titer. This finding suggests that a vaccination strategy for dampening HBV transmission should be carefully addressed in health care workers (HCWs) doing night shift.

Suggested Citation

  • Luca Coppeta & Cristiana Ferrari & Marco Trabucco Aurilio & Gianluigi Ferrazza & Andrea Magrini & Stefano Rizza, 2022. "Night Shift Work Is Associated with Reduced Rate of Humoral Response Following Vaccination for HBV," IJERPH, MDPI, vol. 19(14), pages 1-7, July.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:14:p:8834-:d:867534
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    References listed on IDEAS

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    1. Andrea Trevisan & Paola Mason & Annamaria Nicolli & Stefano Maso & Marco Fonzo & Bruno Scarpa & Chiara Bertoncello, 2021. "Future Healthcare Workers and Hepatitis B Vaccination: A New Generation," IJERPH, MDPI, vol. 18(15), pages 1-9, July.
    2. Luca Coppeta & Cristiana Ferrari & Andrea Mazza & Marco Trabucco Aurilio & Stefano Rizza, 2021. "Factors Associated with Pre-Vaccination SARS-CoV-2 Infection Risk among Hospital Nurses Facing COVID-19 Outbreak," IJERPH, MDPI, vol. 18(24), pages 1-7, December.
    3. Veruscka Leso & Ilaria Vetrani & Alessandra Sicignano & Rosaria Romano & Ivo Iavicoli, 2020. "The Impact of Shift-Work and Night Shift-Work on Thyroid: A Systematic Review," IJERPH, MDPI, vol. 17(5), pages 1-17, February.
    4. Luca Coppeta & Andrea Pompei & Ottavia Balbi & Ludovico M. De Zordo & Federica Mormone & Sara Policardo & Piergiorgio Lieto & Antonio Pietroiusti & Andrea Magrini, 2019. "Persistence of Immunity for Hepatitis B Virus among Heathcare Workers and Italian Medical Students 20 Years after Vaccination," IJERPH, MDPI, vol. 16(9), pages 1-9, April.
    5. Luca Coppeta & Cristiana Ferrari & Ilaria Iannuzzi & Iacopo D’Alessandro & Ottavia Balbi & Antonio Pietroiusti & Marco Trabucco Aurilio, 2020. "Rubella Immunity among Italian Female Healthcare Workers: A Serological Study," IJERPH, MDPI, vol. 17(21), pages 1-6, October.
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