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Serum Trimethylamine N-Oxide Levels Correlate with Metabolic Syndrome in Coronary Artery Disease Patients

Author

Listed:
  • Chiu-Huang Kuo

    (Division of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97004, Taiwan
    School of Post-Baccalaureate Chinese Medicine, Tzu Chi University, Hualien 97004, Taiwan)

  • Chin-Hung Liu

    (Ph.D. Program in Pharmacology and Toxicology, Department of Medicine, School of Medicine, Tzu Chi University, Hualien 97004, Taiwan
    Department of Pharmacology, Tzu Chi University, Hualien 97004, Taiwan)

  • Ji-Hung Wang

    (Division of Cardiology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97004, Taiwan
    School of Medicine, Tzu Chi University, Hualien 97004, Taiwan)

  • Bang-Gee Hsu

    (Division of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97004, Taiwan
    School of Medicine, Tzu Chi University, Hualien 97004, Taiwan)

Abstract

Trimethylamine N-oxide (TMAO) is a gut microbial metabolite that affects atherogenesis and glucose dysregulation. The purpose of this study was to look at the link between blood TMAO levels and metabolic syndrome (MetS) in individuals with coronary artery disease (CAD). Blood samples were obtained in fasting status, and serum TMAO level was quantified by high-performance liquid chromatography–mass spectrometry. MetS and its components were defined according to the International Diabetes Federation diagnostic criteria. Of 92 enrolled patients, 51 (55.4%) had MetS. Patients with MetS had a greater proportion of hypertension and diabetes mellitus, higher body weight, waist circumference, body mass index, systolic blood pressure, fasting glucose, triglycerides, blood urea nitrogen, creatinine, C-reactive protein (CRP), insulin level, homeostasis model assessment of insulin resistance, and TMAO level. Multivariable logistic regression models revealed that TMAO level (odds ratio: 1.036, 95% confidence interval: 1.005–1.067, p = 0.023) could be an effective predictor of MetS among the CAD population. In these patients, the log-TMAO level was positively associated with log-CRP (β = 0.274, p = 0.001) and negatively associated with eGFR (β = −0.235, p = 0.022). In conclusion, our study revealed a positive association between serum TMAO level and MetS among patients with CAD.

Suggested Citation

  • Chiu-Huang Kuo & Chin-Hung Liu & Ji-Hung Wang & Bang-Gee Hsu, 2022. "Serum Trimethylamine N-Oxide Levels Correlate with Metabolic Syndrome in Coronary Artery Disease Patients," IJERPH, MDPI, vol. 19(14), pages 1-9, July.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:14:p:8710-:d:864924
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    References listed on IDEAS

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    1. Zeneng Wang & Elizabeth Klipfell & Brian J. Bennett & Robert Koeth & Bruce S. Levison & Brandon DuGar & Ariel E. Feldstein & Earl B. Britt & Xiaoming Fu & Yoon-Mi Chung & Yuping Wu & Phil Schauer & Jo, 2011. "Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease," Nature, Nature, vol. 472(7341), pages 57-63, April.
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