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Acute Kidney Failure among Brazilian Agricultural Workers: A Death-Certificate Case-Control Study

Author

Listed:
  • Armando Meyer

    (Occupational and Environmental Health Branch, Public Health Institute, Federal University of Rio de Janeiro, Rio de Janeiro 21941-598, Brazil)

  • Aline Souza Espindola Santos

    (Occupational and Environmental Health Branch, Public Health Institute, Federal University of Rio de Janeiro, Rio de Janeiro 21941-598, Brazil)

  • Carmen Ildes Rodrigues Froes Asmus

    (Maternity-School, School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro 22240-000, Brazil)

  • Volney Magalhaes Camara

    (Occupational and Environmental Health Branch, Public Health Institute, Federal University of Rio de Janeiro, Rio de Janeiro 21941-598, Brazil)

  • Antônio José Leal Costa

    (Epidemiology and Biostatistics Branch, Public Health Institute, Federal University of Rio de Janeiro, Rio de Janeiro 21941-598, Brazil)

  • Dale P. Sandler

    (Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA)

  • Christine Gibson Parks

    (Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA)

Abstract

Recent evidence suggests that pesticides may play a role in chronic kidney disease. However, little is known about associations with acute kidney failure (AKF). We investigated trends in AKF and pesticide expenditures and associations with agricultural work in two Brazilian regions with intense use of pesticides, in the south and midwest. Using death certificate data, we investigated trends in AKF mortality (1980–2014). We used joinpoint regression to calculate annual percent changes in AKF mortality rates by urban/rural status and, in rural municipalities, by tertiles of per capita pesticide expenditures. We then compared AKF mortality in farmers and population controls from 2006 to 2014 using logistic regression to estimate odds ratios and 95% confidence intervals adjusted by age, sex, region, education, and race. AKF mortality increased in both regions regardless of urban/rural status; trends were steeper from the mid-1990s to 2000s, and in rural municipalities, they were higher by tertiles of pesticide expenditures. Agricultural workers were more likely to die from AKF than from other causes, especially at younger ages, among females, and in the southern municipalities. We observed increasing AKF mortality in rural areas with greater pesticide expenditures and an association of AKF mortality with agricultural work, especially among younger workers.

Suggested Citation

  • Armando Meyer & Aline Souza Espindola Santos & Carmen Ildes Rodrigues Froes Asmus & Volney Magalhaes Camara & Antônio José Leal Costa & Dale P. Sandler & Christine Gibson Parks, 2022. "Acute Kidney Failure among Brazilian Agricultural Workers: A Death-Certificate Case-Control Study," IJERPH, MDPI, vol. 19(11), pages 1-12, May.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:11:p:6519-:d:825434
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    References listed on IDEAS

    as
    1. Sarath Gunatilake & Stephanie Seneff & Laura Orlando, 2019. "Glyphosate’s Synergistic Toxicity in Combination with Other Factors as a Cause of Chronic Kidney Disease of Unknown Origin," IJERPH, MDPI, vol. 16(15), pages 1-26, July.
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