IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v19y2022i10p6221-d819996.html
   My bibliography  Save this article

Rapid Assessment of Oxidative Damage Potential: A Comparative Study of Engineered Stone Dusts Using a Deoxyguanosine Assay

Author

Listed:
  • Leigh Thredgold

    (Adelaide Exposure Science and Health, School of Public Health, University of Adelaide, Adelaide, SA 5005, Australia)

  • Chandnee Ramkissoon

    (Adelaide Exposure Science and Health, School of Public Health, University of Adelaide, Adelaide, SA 5005, Australia)

  • Chellan Kumarasamy

    (Adelaide Exposure Science and Health, School of Public Health, University of Adelaide, Adelaide, SA 5005, Australia)

  • Richard Gun

    (Adelaide Exposure Science and Health, School of Public Health, University of Adelaide, Adelaide, SA 5005, Australia)

  • Shelley Rowett

    (SafeWork SA, Government of South Australia, Adelaide, SA 5035, Australia)

  • Sharyn Gaskin

    (Adelaide Exposure Science and Health, School of Public Health, University of Adelaide, Adelaide, SA 5005, Australia)

Abstract

The popularity of engineered stone (ES) has been associated with a global increase in occupational lung disease in workers exposed to respirable dust during the fabrication of benchtops and other ES products. In this study, the reactivity and subsequent oxidative reduction potential of freshly generated ES dusts were evaluated by (i) comparing different engineered and natural stones, (ii) comparing settled and respirable stone dust fractions and (iii) assessing the effect of ageing on the reactivity of freshly generated stone dust. An established cell-free deoxyguanosine hydroxylation assay was used to assess the potential for oxidative DNA damage. ES dust exhibited a higher relative reactivity than two of the three natural stones tested. Respirable dust fractions were found to be significantly more reactive than their corresponding settled fraction (ANOVA, p < 0.05) across all stone types and samples. However, settled dust still displayed high relative reactivity. The lower reactivity of the settled dust was not due to decay in reactivity of the respirable dust when it settled but rather a result of the admixture of larger nonrespirable particles. No significant change in respirable dust reactivity was observed for three ES samples over a 21-day time period, whereas a significant decrease in reactivity was observed in the natural stone studied. This study has practical implications for dust control and housekeeping in industry, risk assessment and hazard management.

Suggested Citation

  • Leigh Thredgold & Chandnee Ramkissoon & Chellan Kumarasamy & Richard Gun & Shelley Rowett & Sharyn Gaskin, 2022. "Rapid Assessment of Oxidative Damage Potential: A Comparative Study of Engineered Stone Dusts Using a Deoxyguanosine Assay," IJERPH, MDPI, vol. 19(10), pages 1-10, May.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:10:p:6221-:d:819996
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/19/10/6221/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/19/10/6221/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Veruscka Leso & Luca Fontana & Rosaria Romano & Paola Gervetti & Ivo Iavicoli, 2019. "Artificial Stone Associated Silicosis: A Systematic Review," IJERPH, MDPI, vol. 16(4), pages 1-17, February.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Mar Requena-Mullor & Raquel Alarcón-Rodríguez & Tesifón Parrón-Carreño & Jose Joaquín Martínez-López & David Lozano-Paniagua & Antonio F. Hernández, 2021. "Association between Crystalline Silica Dust Exposure and Silicosis Development in Artificial Stone Workers," IJERPH, MDPI, vol. 18(11), pages 1-10, May.
    2. Veruscka Leso & Luca Fontana & Rosaria Romano & Paola Gervetti & Ivo Iavicoli, 2019. "Reply to Accelerated Silicosis—An Emerging Epidemic Associated with Engineered Stone. Comment on Leso, V. et al. Artificial Stone-Associated Silicosis: A Systematic Review. Int. J. Environ. Res. Publi," IJERPH, MDPI, vol. 16(7), pages 1-3, April.
    3. Rachel Raanan & Oren Zack & Maya Ruben & Idan Perluk & Shlomo Moshe, 2022. "Occupational Silica Exposure and Dose–Response for Related Disorders—Silicosis, Pulmonary TB, AIDs and Renal Diseases: Results of a 15-Year Israeli Surveillance," IJERPH, MDPI, vol. 19(22), pages 1-10, November.
    4. Graeme Edwards, 2019. "Accelerated Silicosis—An Emerging Epidemic Associated with Engineered Stone. Comment on Leso, V. et al. Artificial Stone Associated Silicosis: A Systematic Review. Int. J. Environ. Res. Public Health ," IJERPH, MDPI, vol. 16(7), pages 1-2, April.
    5. Preeti Maharjan & Joseph Crea & Michael Tkaczuk & Sharyn Gaskin & Dino Pisaniello, 2021. "Metal Ion Release from Engineered Stone Dust in Artificial Lysosomal Fluid—Variation with Time and Stone Type," IJERPH, MDPI, vol. 18(12), pages 1-11, June.
    6. Chandnee Ramkissoon & Sharyn Gaskin & Yong Song & Dino Pisaniello & Graeme R. Zosky, 2024. "From Engineered Stone Slab to Silicosis: A Synthesis of Exposure Science and Medical Evidence," IJERPH, MDPI, vol. 21(6), pages 1-15, May.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:19:y:2022:i:10:p:6221-:d:819996. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.