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Treatment Compliance of Multidrug Resistant Tuberculosis in Uzbekistan: Does Practice Follow Policy?

Author

Listed:
  • Ruzilya Usmanova

    (Republican Specialized Scientific-Practical Medical Center of Phthisiology and Pulmonology of the Republic of Uzbekistan, 1 Majlisiy Street, Shayhantahur District, Tashkent 100086, Uzbekistan)

  • Nargiza Parpieva

    (Republican Specialized Scientific-Practical Medical Center of Phthisiology and Pulmonology of the Republic of Uzbekistan, 1 Majlisiy Street, Shayhantahur District, Tashkent 100086, Uzbekistan)

  • Hayk Davtyan

    (Tuberculosis Research and Prevention Center, NGO, 38 Apartment, 33 Charents Street, Nor Hachn 2412, Armenia)

  • Olga Denisiuk

    (Alliance for Public Health, Building 3, 24 Bulvarno-Kudryavska Street, 01601 Kyiv, Ukraine)

  • Jamshid Gadoev

    (World Health Organization (WHO) Country Office in Uzbekistan, 16 Tarobiy Street, Tashkent 100100, Uzbekistan)

  • Sevak Alaverdyan

    (Bielefeld Graduate School of Economics and Management (BiGSEM), Bielefeld University, 25 Universitätsstraße, 33615 Bielefeld, Germany)

  • Kostyantyn Dumchev

    (Ukrainian Institute of Public Health Policy, Biloruska Street, 5, 02000 Kyiv, Ukraine)

  • Irina Liverko

    (Republican Specialized Scientific-Practical Medical Center of Phthisiology and Pulmonology of the Republic of Uzbekistan, 1 Majlisiy Street, Shayhantahur District, Tashkent 100086, Uzbekistan)

  • Barno Abdusamatova

    (Department of Protection of Maternity and Childhood of the Ministry of Health, 12 Navoi Street, Shayhantahur District, Tashkent 100011, Uzbekistan)

Abstract

Compliance with treatment guidelines is essential to achieve successful outcomes in tuberculosis patients. Thus, we assessed if multidrug-resistant tuberculosis treatment practices from 2012–2018 in Uzbekistan were compliant with national guidelines in terms of regimens prescribed, weight-based drug dosages used, and documentation of treatment changes (such as prolongation of intensive phase, change of drugs, and their reasons) in the treatment card and Consilium form. A total of 1481 patients were included. Of them, only 25% received standardized regimens as per guidelines and the remaining received individualized regimens. There was an increasing trend in using standardized regimens from 2% in 2012 to 44% in 2018. Compliance to recommended weight-based drug dosages was observed in 85% of the patients during the intensive phase and 84% in the continuation phase—ranged 71–91% over the years. Prolongation of the intensive phase was done in 42% of patients. The treatment was changed in 44% of patients during the intensive phase and 34% of patients during the continuation phase. The documentation of treatment changes was suboptimal (42–75%) during the initial years (2012–2014); however, it improved significantly during later years (86–100%). Future research should explore reasons for non-compliance so that the quality of patient care can be improved.

Suggested Citation

  • Ruzilya Usmanova & Nargiza Parpieva & Hayk Davtyan & Olga Denisiuk & Jamshid Gadoev & Sevak Alaverdyan & Kostyantyn Dumchev & Irina Liverko & Barno Abdusamatova, 2021. "Treatment Compliance of Multidrug Resistant Tuberculosis in Uzbekistan: Does Practice Follow Policy?," IJERPH, MDPI, vol. 18(8), pages 1-11, April.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:8:p:4071-:d:534816
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    Citations

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    Cited by:

    1. Jamshid Gadoev & Damin Asadov & Anthony D. Harries & Ajay M. V. Kumar & Martin Johan Boeree & Araksya Hovhannesyan & Lianne Kuppens & Askar Yedilbayev & Oleksandr Korotych & Atadjan Hamraev & Kallibek, 2021. "Factors Associated with Unfavourable Treatment Outcomes in Patients with Tuberculosis: A 16-Year Cohort Study (2005–2020), Republic of Karakalpakstan, Uzbekistan," IJERPH, MDPI, vol. 18(23), pages 1-19, December.

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