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Factors Associated with Unfavourable Treatment Outcomes in Patients with Tuberculosis: A 16-Year Cohort Study (2005–2020), Republic of Karakalpakstan, Uzbekistan

Author

Listed:
  • Jamshid Gadoev

    (WHO Country Office in Uzbekistan, 16-Tarobiy, Tashkent 100100, Uzbekistan)

  • Damin Asadov

    (Center of Development of Professional Qualification of Medical Personnel, Tashkent 100007, Uzbekistan)

  • Anthony D. Harries

    (Centre for Operational Research, International Union Against Tuberculosis and Lung Disease, 2 Rue Jean Lantier, 75001 Paris, France
    Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK)

  • Ajay M. V. Kumar

    (Centre for Operational Research, International Union Against Tuberculosis and Lung Disease, 2 Rue Jean Lantier, 75001 Paris, France
    International Union Against Tuberculosis and Lung Disease, South-East Asia Office, C-6, Qutub Institutional Area, New Delhi 110016, India
    Yenepoya Medical College, Yenepoya (Deemed to be University), Mangaluru 575018, India)

  • Martin Johan Boeree

    (Department of Lung Diseases, Radboudumc, 6500 HB Nijmegen/TB Expert Centre Dekkerswald, 6561KE Groesbeek, The Netherlands)

  • Araksya Hovhannesyan

    (World Health Organization Regional Office for Europe, UN City, Marmorvej 51, DK-2100 Copenhagen, Denmark)

  • Lianne Kuppens

    (WHO Country Office in Uzbekistan, 16-Tarobiy, Tashkent 100100, Uzbekistan)

  • Askar Yedilbayev

    (World Health Organization Regional Office for Europe, UN City, Marmorvej 51, DK-2100 Copenhagen, Denmark)

  • Oleksandr Korotych

    (World Health Organization Regional Office for Europe, UN City, Marmorvej 51, DK-2100 Copenhagen, Denmark)

  • Atadjan Hamraev

    (Center of Development of Professional Qualification of Medical Personnel, Tashkent 100007, Uzbekistan)

  • Kallibek Kudaybergenov

    (Republican Phthisiology and Pulmonology Center Named after Sultanov, Nukus 1735401, Republic of Karakalpakstan)

  • Barno Abdusamatova

    (Ministry of Health of Republic of Uzbekistan, Tashkent 100011, Uzbekistan)

  • Bakhtinur Khudanov

    (Ministry of Health of Republic of Uzbekistan, Tashkent 100011, Uzbekistan)

  • Masoud Dara

    (World Health Organization Regional Office for Europe, UN City, Marmorvej 51, DK-2100 Copenhagen, Denmark)

Abstract

Tuberculosis (TB) remains a public health burden in the Republic of Karakalpakstan, Uzbekistan. This region-wide retrospective cohort study reports the treatment outcomes of patients registered in the TB electronic register and treated with first-line drugs in the TB Programme of the Republic of Karakalpakstan from 2005–2020 and factors associated with unfavourable outcomes. Among 35,122 registered patients, 24,394 (69%) patients were adults, 2339 (7%) were children, 18,032 (51%) were male and 19,774 (68%) lived in rural areas. Of these patients, 29,130 (83%) had pulmonary TB and 7497 (>22%) had been previously treated. There were 7440 (21%) patients who had unfavourable treatment outcomes. Factors associated with unfavourable treatment outcomes included: increasing age, living in certain parts of the republic, disability, pensioner status, unemployment, being HIV-positive, having pulmonary TB, and receiving category II treatment. Factors associated with death included: being adult and elderly, living in certain parts of the republic, having a disability, pensioner status, being HIV-positive, and receiving category II treatment. Factors associated with failure included: being adolescent, female, having pulmonary TB. Factors associated with loss to follow-up included: being male, disability, pensioner status, unemployment, receiving category II treatment. In summary, there are sub-groups of patients who need special attention in order to decrease unfavourable treatment outcomes.

Suggested Citation

  • Jamshid Gadoev & Damin Asadov & Anthony D. Harries & Ajay M. V. Kumar & Martin Johan Boeree & Araksya Hovhannesyan & Lianne Kuppens & Askar Yedilbayev & Oleksandr Korotych & Atadjan Hamraev & Kallibek, 2021. "Factors Associated with Unfavourable Treatment Outcomes in Patients with Tuberculosis: A 16-Year Cohort Study (2005–2020), Republic of Karakalpakstan, Uzbekistan," IJERPH, MDPI, vol. 18(23), pages 1-19, December.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:23:p:12827-:d:695652
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    References listed on IDEAS

    as
    1. Anvar Riskiyev & Ana Ciobanu & Arax Hovhannesyan & Kristina Akopyan & Jamshid Gadoev & Nargiza Parpieva, 2021. "Characteristics and Treatment Outcomes of Patients with Tuberculosis Receiving Adjunctive Surgery in Uzbekistan," IJERPH, MDPI, vol. 18(12), pages 1-12, June.
    2. Ruzilya Usmanova & Nargiza Parpieva & Hayk Davtyan & Olga Denisiuk & Jamshid Gadoev & Sevak Alaverdyan & Kostyantyn Dumchev & Irina Liverko & Barno Abdusamatova, 2021. "Treatment Compliance of Multidrug Resistant Tuberculosis in Uzbekistan: Does Practice Follow Policy?," IJERPH, MDPI, vol. 18(8), pages 1-11, April.
    3. Aleksandr Trubnikov & Arax Hovhannesyan & Kristina Akopyan & Ana Ciobanu & Dilbar Sadirova & Lola Kalandarova & Nargiza Parpieva & Jamshid Gadoev, 2021. "Effectiveness and Safety of a Shorter Treatment Regimen in a Setting with a High Burden of Multidrug-Resistant Tuberculosis," IJERPH, MDPI, vol. 18(8), pages 1-16, April.
    4. Sharofiddin Yuldashev & Nargiza Parpieva & Salikhdjan Alimov & Laziz Turaev & Khasan Safaev & Kostyantyn Dumchev & Jamshid Gadoev & Oleksandr Korotych & Anthony D. Harries, 2021. "Scaling Up Molecular Diagnostic Tests for Drug-Resistant Tuberculosis in Uzbekistan from 2012–2019: Are We on the Right Track?," IJERPH, MDPI, vol. 18(9), pages 1-14, April.
    5. Khasan Safaev & Nargiza Parpieva & Irina Liverko & Sharofiddin Yuldashev & Kostyantyn Dumchev & Jamshid Gadoev & Oleksandr Korotych & Anthony D. Harries, 2021. "Trends, Characteristics and Treatment Outcomes of Patients with Drug-Resistant Tuberculosis in Uzbekistan: 2013–2018," IJERPH, MDPI, vol. 18(9), pages 1-15, April.
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