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Associations of Prenatal Exposure to Phthalates with Measures of Cognition in 4.5-Month-Old Infants

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  • Francheska M. Merced-Nieves

    (Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
    Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
    Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA)

  • Kelsey L. C. Dzwilewski

    (Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
    Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA)

  • Andrea Aguiar

    (Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
    Department of Comparative Biosciences, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA)

  • Salma Musaad

    (USDA/ARS Children’s Nutrition Research Center, Baylor College of Medicine, Houston, TX 77030, USA)

  • Susan A. Korrick

    (Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA)

  • Susan L. Schantz

    (Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
    Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
    Department of Comparative Biosciences, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA)

Abstract

The association of prenatal phthalate exposure with physical reasoning was assessed in 159 (78 female; 81 male) 4.5-month-old infants from a prospective cohort. Phthalate metabolites were quantified in urine from 16–18 gestational weeks and a pool of five urines from across pregnancy. Infants’ looking times to physically impossible and possible events were recorded via infrared eye-tracking. Infants that recognize that one of the events is impossible will look at that event longer. Associations of phthalate biomarkers with looking time differences (impossible–possible) were adjusted for maternal age, infant sex, and order of event presentation, and effect modification by infant sex was assessed. Each interquartile range (IQR) increase of monoethyl phthalate in the pooled sample was associated with females’ increased looking time (β = 1.0; 95%CI = 0.3, 1.7 s) to the impossible event. However, for males, an IQR increase in monoethyl phthalate at 16–18 weeks (β = −2.5; 95%CI = −4.4,−0.6 s), the sum of di(isononyl) phthalate metabolites in the pooled sample (β = −1.0; 95%CI = −1.8, −0.1 s), and the sum of all phthalate metabolites in both samples (β = −2.3; 95%CI = −4.4, −0.2 s) were associated with increased looking to the possible event, suggesting that higher prenatal phthalate exposure is associated with poorer physical reasoning in male infants.

Suggested Citation

  • Francheska M. Merced-Nieves & Kelsey L. C. Dzwilewski & Andrea Aguiar & Salma Musaad & Susan A. Korrick & Susan L. Schantz, 2021. "Associations of Prenatal Exposure to Phthalates with Measures of Cognition in 4.5-Month-Old Infants," IJERPH, MDPI, vol. 18(4), pages 1-13, February.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:4:p:1838-:d:499093
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    References listed on IDEAS

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    1. Ron Brookmeyer, 1999. "Analysis of Multistage Pooling Studies of Biological Specimens for Estimating Disease Incidence and Prevalence," Biometrics, The International Biometric Society, vol. 55(2), pages 608-612, June.
    2. Clarice R. Weinberg & David M. Umbach, 1999. "Using Pooled Exposure Assessment to Improve Efficiency in Case-Control Studies," Biometrics, The International Biometric Society, vol. 55(3), pages 718-726, September.
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