IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v18y2021i2p779-d482404.html
   My bibliography  Save this article

Efficacy of Three Commercial Disinfectants in Reducing Microbial Surfaces’ Contaminations of Pharmaceuticals Hospital Facilities

Author

Listed:
  • Giuseppina Di Martino

    (Unità di Medicina di Laboratorio e Biotecnologie Avanzate, IRCCS-ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione), Via E. Tricomi 5, 90127 Palermo, Italy)

  • Salvatore Pasqua

    (Unità Prodotti Cellulari (GMP), Fondazione Ri.MED c/o IRCCS-ISMETT, Via E. Tricomi 5, 90127 Palermo, Italy)

  • Bruno Douradinha

    (Unità di Medicina di Laboratorio e Biotecnologie Avanzate, IRCCS-ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione), Via E. Tricomi 5, 90127 Palermo, Italy
    Unità Medicina Rigenerativa ed Immunoterapia, Fondazione Ri.MED c/o IRCCS-ISMETT, Via E. Tricomi 5, 90127 Palermo, Italy)

  • Francesco Monaco

    (Unità di Medicina di Laboratorio e Biotecnologie Avanzate, IRCCS-ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione), Via E. Tricomi 5, 90127 Palermo, Italy)

  • Chiara Di Bartolo

    (Unità di Medicina di Laboratorio e Biotecnologie Avanzate, IRCCS-ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione), Via E. Tricomi 5, 90127 Palermo, Italy
    Unità Prodotti Cellulari (GMP), Fondazione Ri.MED c/o IRCCS-ISMETT, Via E. Tricomi 5, 90127 Palermo, Italy)

  • Pier Giulio Conaldi

    (Unità di Medicina di Laboratorio e Biotecnologie Avanzate, IRCCS-ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione), Via E. Tricomi 5, 90127 Palermo, Italy)

  • Danilo D’Apolito

    (Unità di Medicina di Laboratorio e Biotecnologie Avanzate, IRCCS-ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione), Via E. Tricomi 5, 90127 Palermo, Italy
    Unità Prodotti Cellulari (GMP), Fondazione Ri.MED c/o IRCCS-ISMETT, Via E. Tricomi 5, 90127 Palermo, Italy)

Abstract

To evaluate and validate the efficacy of disinfectants used in our cleaning procedure, in order to reduce pharmaceutical hospital surfaces’ contaminations, we tested the action of three commercial disinfectants on small representative samples of the surfaces present in our hospital cleanrooms. These samples (or coupons) were contaminated with selected microorganisms for the validation of the disinfectants. The coupons were sampled before and after disinfection and the microbial load was assessed to calculate the Log 10 reduction index. Subsequently, we developed and validated a disinfection procedure on real surfaces inside the cleanrooms intentionally contaminated with microorganisms, using approximately 10 7 –10 8 total colony forming units per coupon. Our results showed a bactericidal, fungicidal, and sporicidal efficacy coherent to the acceptance criteria suggested by United States Pharmacopeia 35 <1072>. The correct implementation of our cleaning and disinfection procedure, respecting stipulated concentrations and contact times, led to a reduction of at least 6 Log 10 for all microorganisms used. The proposed disinfection procedure reduced the pharmaceutical hospital surfaces’ contaminations, limited the propagation of microorganisms in points adjacent to the disinfected area, and ensured high disinfection and safety levels for operators, patients, and treated surfaces.

Suggested Citation

  • Giuseppina Di Martino & Salvatore Pasqua & Bruno Douradinha & Francesco Monaco & Chiara Di Bartolo & Pier Giulio Conaldi & Danilo D’Apolito, 2021. "Efficacy of Three Commercial Disinfectants in Reducing Microbial Surfaces’ Contaminations of Pharmaceuticals Hospital Facilities," IJERPH, MDPI, vol. 18(2), pages 1-11, January.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:2:p:779-:d:482404
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/18/2/779/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/18/2/779/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Maria Teresa Montagna & Francesco Triggiano & Giovanna Barbuti & Nicola Bartolomeo & Osvalda De Giglio & Giusy Diella & Marco Lopuzzo & Serafina Rutigliano & Gabriella Serio & Giuseppina Caggiano, 2019. "Study on the In Vitro Activity of Five Disinfectants against Nosocomial Bacteria," IJERPH, MDPI, vol. 16(11), pages 1-9, May.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Giuseppina Caggiano & Francesco Triggiano & Giusy Diella & Francesca Apollonio & Marco Lopuzzo & Adriana Mosca & Stefania Stolfa & Carlo Pazzani & Marta Oliva & Carla Calia & Nicola Laforgia & Lidia D, 2021. "A Possible Outbreak by Serratia marcescens : Genetic Relatedness between Clinical and Environmental Strains," IJERPH, MDPI, vol. 18(18), pages 1-9, September.
    2. Francesco Triggiano & Giuseppina Caggiano & Marco Lopuzzo & Giusy Diella & Francesca Apollonio & Fabrizio Fasano & Maria Teresa Montagna, 2022. "No-Touch Automated Disinfection System Based on Hydrogen Peroxide and Ethyl Alcohol Aerosols for Use in Healthcare Environments," IJERPH, MDPI, vol. 19(8), pages 1-6, April.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:18:y:2021:i:2:p:779-:d:482404. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.