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Negative Association between Acrylamide Exposure and Metabolic Syndrome Markers in Adult Population

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  • Chun-Chi Hung

    (Department of Orthopaedic Surgery, Tri-Service General Hospital, Taipei 114, Taiwan
    School of Medicine, National Defense Medical Center, Taipei 114, Taiwan)

  • Yung-Wen Cheng

    (School of Medicine, National Defense Medical Center, Taipei 114, Taiwan
    Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, Taipei 114, Taiwan)

  • Wei-Liang Chen

    (School of Medicine, National Defense Medical Center, Taipei 114, Taiwan
    Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, Taipei 114, Taiwan
    Division of Geriatric Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, Taipei 114, Taiwan
    Department of Biochemistry, National Defense Medical Center, Taipei 114, Taiwan)

  • Wen-Hui Fang

    (School of Medicine, National Defense Medical Center, Taipei 114, Taiwan
    Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, Taipei 114, Taiwan)

Abstract

Metabolic syndrome encompasses multiple conditions that increase the risk of cardiovascular disease, and exposure to environmental chemicals can cause metabolic syndrome. This cross-sectional study analyzed data from the US National Health and Nutrition Examination Survey (2003–2006) on 4318 adult participants to assess the association between acrylamide (AA) exposure and metabolic syndrome. Concentrations of hemoglobin-adducted AA (HbAA) and hemoglobin-adducted glycidamide (HbGA) were evaluated. Metabolic syndrome markers related to HbAA and HbGA and the effect of exposure to AA and GA on the prevalence of metabolic syndrome were studied by ANOVA and multivariate logistic regression analyses, respectively. HbAA concentration inversely correlated with the number of metabolic syndrome markers ( p < 0.05). An increased HbAA concentration was noted with reduced high triglyceride and low high-density lipoprotein cholesterol levels in the adjusted model ( p < 0.05). High fasting plasma glucose level significantly correlated with HbGA concentration in the adjusted model. In conclusion, AA exposure alters metabolic syndrome markers in adults. Additional clinical and animal studies will clarify the role of AA exposure at different stages in the progression of metabolic syndrome-related diseases.

Suggested Citation

  • Chun-Chi Hung & Yung-Wen Cheng & Wei-Liang Chen & Wen-Hui Fang, 2021. "Negative Association between Acrylamide Exposure and Metabolic Syndrome Markers in Adult Population," IJERPH, MDPI, vol. 18(22), pages 1-10, November.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:22:p:11949-:d:678734
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    References listed on IDEAS

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    1. Yun Hwa Shim & Jung Won Ock & Yoon-Ji Kim & Youngki Kim & Se Yeong Kim & Dongmug Kang, 2019. "Association between Heavy Metals, Bisphenol A, Volatile Organic Compounds and Phthalates and Metabolic Syndrome," IJERPH, MDPI, vol. 16(4), pages 1-12, February.
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