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Is the Antibacterial Activity of Multi-Walled Carbon Nanotubes (MWCNTs) Related to Antibiotic Resistance? An Assessment in Clinical Isolates

Author

Listed:
  • Pasqualina Laganà

    (Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98125 Messina, Italy)

  • Giuseppa Visalli

    (Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98125 Messina, Italy)

  • Alessio Facciolà

    (Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98125 Messina, Italy)

  • Marianna Pruiti Ciarello

    (Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98125 Messina, Italy)

  • Antonio Laganà

    (Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98125 Messina, Italy)

  • Daniela Iannazzo

    (Department of Electronic Engineering, Industrial Chemistry and Engineering, University of Messina, 98125 Messina, Italy)

  • Angela Di Pietro

    (Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98125 Messina, Italy)

Abstract

Antimicrobial resistance has spread globally, compromising the treatment of common infections. This feature is particularly harmful for nosocomial pathogens that can survive on hospital surfaces. Research studies have been conducted to evaluate new materials that are able to counteract the microbial growth and the colonization of the hospital environment. In this context, nanotechnologies have showed encouraging applications. We investigated the antibacterial activity of multi-walled carbon nanotubes (MWCNTs), both pristine (p) and functionalized (f), at concentrations of 50 and 100 μg mL −1 , against bacterial strains isolated from hospital-acquired infections, and this activity was correlated with the antibiotic susceptibility of the strains. The inhibiting effect of MWCNTs occurred for both types and doses tested. Moreover, f-MWCNTs exerted a greater inhibiting effect, with growth decreases greater than 10% at 24 h and 20% at 48 h compared to p-MWCNTs. Moreover, a lower inhibitory effect of MWCNTs, which was more lasting in Gram-positives resistant to cell wall antibiotics, or temporary in Gram-negatives resistant to nucleic acid and protein synthesis inhibitors, was observed, highlighting the strong relation between antibiotic resistance and MWCNT effect. In conclusion, an antimicrobial activity was observed especially for f-MWCNTs that could therefore be loaded with bioactive antimicrobial molecules. However, this potential application of CNTs presupposes the absence of toxicity and therefore total safety for patients.

Suggested Citation

  • Pasqualina Laganà & Giuseppa Visalli & Alessio Facciolà & Marianna Pruiti Ciarello & Antonio Laganà & Daniela Iannazzo & Angela Di Pietro, 2021. "Is the Antibacterial Activity of Multi-Walled Carbon Nanotubes (MWCNTs) Related to Antibiotic Resistance? An Assessment in Clinical Isolates," IJERPH, MDPI, vol. 18(17), pages 1-11, September.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:17:p:9310-:d:628475
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    References listed on IDEAS

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    1. Giuseppa Visalli & Alessio Facciolà & Monica Currò & Pasqualina Laganà & Vincenza La Fauci & Daniela Iannazzo & Alessandro Pistone & Angela Di Pietro, 2019. "Mitochondrial Impairment Induced by Sub-Chronic Exposure to Multi-Walled Carbon Nanotubes," IJERPH, MDPI, vol. 16(5), pages 1-13, March.
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