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Mercury and Antibiotic Resistance Co-Selection in Bacillus sp. Isolates from the Almadén Mining District

Author

Listed:
  • Marina Robas

    (Department of Pharmaceutical and Health Sciences, Universidad San Pablo CEU, 28668 Boadilla del Monte, Spain)

  • Agustín Probanza

    (Department of Pharmaceutical and Health Sciences, Universidad San Pablo CEU, 28668 Boadilla del Monte, Spain)

  • Daniel González

    (Department of Pharmaceutical and Health Sciences, Universidad San Pablo CEU, 28668 Boadilla del Monte, Spain)

  • Pedro A. Jiménez

    (Department of Pharmaceutical and Health Sciences, Universidad San Pablo CEU, 28668 Boadilla del Monte, Spain)

Abstract

Antibiotic resistance (AR) in the environment is of great global concern and a threat to public health. Soil bacteria, including Bacillus spp., could act as recipients and reservoirs of AR genes of clinical, livestock, or agricultural origin. These genes can be shared between bacteria, some of which could be potentially human pathogens. This process can be favored in conditions of abiotic stress, such as heavy metal contamination. The Almadén mining district (Ciudad Real, Spain) is one of the environments with the highest mercury (Hg) contamination worldwide. The link between heavy metal contamination and increased AR in environmental bacteria seems clear, due to co-resistance and co-selection phenomena. In the present study, 53 strains were isolated from rhizospheric and bulk soil samples in Almadén. AR was tested using Vitek ® 2 and minimum inhibitory concentration (MIC) values were obtained and interpreted based on the criteria of the Clinical and Laboratory Standards Institute (CLSI) guidelines. Based on the resistance profiles, five different antibiotypes were established. The Hg minimum bactericidal concentration (MBC) of each strain was obtained using the plating method with increasing concentrations of HgCl2. A total of 72% of Bacillus spp. showed resistance to two or more commonly used antibiotics. A total of 38 isolates expressed AR to cephalosporins. Finally, the environmental co-selection of AR to cephalosporins and tetracyclines by selective pressure of Hg has been statistically demonstrated.

Suggested Citation

  • Marina Robas & Agustín Probanza & Daniel González & Pedro A. Jiménez, 2021. "Mercury and Antibiotic Resistance Co-Selection in Bacillus sp. Isolates from the Almadén Mining District," IJERPH, MDPI, vol. 18(16), pages 1-11, August.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:16:p:8304-:d:608999
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    References listed on IDEAS

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    1. Manuel Delgado-Baquerizo & Carlos A. Guerra & Concha Cano-Díaz & Eleonora Egidi & Jun-Tao Wang & Nico Eisenhauer & Brajesh K. Singh & Fernando T. Maestre, 2020. "The proportion of soil-borne pathogens increases with warming at the global scale," Nature Climate Change, Nature, vol. 10(6), pages 550-554, June.
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