IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v18y2021i14p7553-d594991.html
   My bibliography  Save this article

BDNF Impact on Biological Markers of Depression—Role of Physical Exercise and Training

Author

Listed:
  • Eugenia Murawska-Ciałowicz

    (Physiology and Biochemistry Department, University School of Physical Education, 51-612 Wroclaw, Poland)

  • Mona Wiatr

    (Department of Physiotherapy, Physiotherapy Faculty, Medical University in Wroclaw, 50-355 Wroclaw, Poland)

  • Maria Ciałowicz

    (Physiotherapy Faculty, University School of Physical Education, 51-612 Wroclaw, Poland)

  • Gilmara Gomes de Assis

    (Department of Molecular Biology, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland)

  • Wojciech Borowicz

    (Neurological Diseases Department, Medical University in Wroclaw, 51-618 Wroclaw, Poland)

  • Silvia Rocha-Rodrigues

    (Escola Superior de Desporto e Lazer, Instituto Politécnico de Viana do Castelo, Rua Escola Industrial Comercial de Nun’Álvares, 4900-347 Viana do Castelo, Portugal
    Health Sciences and Human Development (CIDESD), Research Centre in Sports Sciences, Quinta de Prados, Edifício Ciências de Desporto, 5001-801 Vila Real, Portugal
    Tumor & Microenvironment Interactions Group, i3S, Rua Alfredo Allen 208, 4200-135 Porto, Portugal)

  • Małgorzata Paprocka-Borowicz

    (Department of Physiotherapy, Physiotherapy Faculty, Medical University in Wroclaw, 50-355 Wroclaw, Poland)

  • Adilson Marques

    (CIPER, Faculty of Human Kinetics, University of Lisboa, 1499-002 Cruz Quebrada, Portugal)

Abstract

Depression is the most common and devastating psychiatric disorder in the world. Its symptoms, especially during the pandemic, are observed in all age groups. Exercise training (ET) is well known as a non-pharmacological strategy to alleviate clinical depression. The brain-derived neurotrophic factor (BDNF) is one of the biological factors whose expression and secretion are intensified in response to ET. BDNF is also secreted by contracted skeletal muscle that likely exerts para-, auto- and endocrine effects, supporting the crosstalk between skeletal muscle and other distant organs/tissues, such as the nervous system. This finding suggests that they communicate and work together to induce improvements on mood, cognition, and learning processes as BDNF is the main player in the neurogenesis, growth, and survival of neurons. Therefore, BDNF has been recognized as a therapeutic factor in clinical depression, especially in response to ET. The underlying mechanisms through which ET impacts depression are varied. The aim of this review was to provide information of the biological markers of depression such as monoamines, tryptophan, endocannabinoids, markers of inflammatory processes (oxidative stress and cytokines) stress and sex hormones and their relationship to BDNF. In addition, we reviewed the effects of ET on BNDF expression and how it impacts depression as well as the potential mechanisms mediating this process, providing a better understanding of underlying ET-related mechanisms in depression.

Suggested Citation

  • Eugenia Murawska-Ciałowicz & Mona Wiatr & Maria Ciałowicz & Gilmara Gomes de Assis & Wojciech Borowicz & Silvia Rocha-Rodrigues & Małgorzata Paprocka-Borowicz & Adilson Marques, 2021. "BDNF Impact on Biological Markers of Depression—Role of Physical Exercise and Training," IJERPH, MDPI, vol. 18(14), pages 1-21, July.
  • Handle: RePEc:gam:jijerp:v:18:y:2021:i:14:p:7553-:d:594991
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/18/14/7553/pdf
    Download Restriction: no

    File URL: https://www.mdpi.com/1660-4601/18/14/7553/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Nephi Stella & Paul Schweitzer & Daniele Piomelli, 1997. "A second endogenous cannabinoid that modulates long-term potentiation," Nature, Nature, vol. 388(6644), pages 773-778, August.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Nicola Forte & Serena Boccella & Lea Tunisi & Alba Clara Fernández-Rilo & Roberta Imperatore & Fabio Arturo Iannotti & Maria Risi & Monica Iannotta & Fabiana Piscitelli & Raffaele Capasso & Paolo Giro, 2021. "Orexin-A and endocannabinoids are involved in obesity-associated alteration of hippocampal neurogenesis, plasticity, and episodic memory in mice," Nature Communications, Nature, vol. 12(1), pages 1-20, December.
    2. Nathan Fearby & Samantha Penman & Panayotis Thanos, 2022. "Effects of Δ9-Tetrahydrocannibinol (THC) on Obesity at Different Stages of Life: A Literature Review," IJERPH, MDPI, vol. 19(6), pages 1-28, March.
    3. David J Marcus & Angela N Henderson-Redmond & Maciej Gonek & Michael L Zee & Jill C Farnsworth & Randa A Amin & Mary-Jeanette Andrews & Brian J Davis & Ken Mackie & Daniel J Morgan, 2017. "Mice expressing a “hyper-sensitive” form of the CB1 cannabinoid receptor (CB1) show modestly enhanced alcohol preference and consumption," PLOS ONE, Public Library of Science, vol. 12(4), pages 1-17, April.
    4. Kirsten Bohmbach & Nicola Masala & Eva M. Schönhense & Katharina Hill & André N. Haubrich & Andreas Zimmer & Thoralf Opitz & Heinz Beck & Christian Henneberger, 2022. "An astrocytic signaling loop for frequency-dependent control of dendritic integration and spatial learning," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    5. Masahiro Matsunaga & Takahiko Masuda & Keiko Ishii & Yohsuke Ohtsubo & Yasuki Noguchi & Misaki Ochi & Hidenori Yamasue, 2018. "Culture and cannabinoid receptor gene polymorphism interact to influence the perception of happiness," PLOS ONE, Public Library of Science, vol. 13(12), pages 1-17, December.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:18:y:2021:i:14:p:7553-:d:594991. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.