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Comparative Toxic Effects of Manufactured Nanoparticles and Atmospheric Particulate Matter in Human Lung Epithelial Cells

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  • Yun Wu

    (Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control (AEMPC), Collaborative Innovation Center of Atmospheric Environment and Equipment Technology (AEET), School of Environmental Science and Engineering, Nanjing University of Information Science & Technology (NUIST), Nanjing 210044, China)

  • Mei Wang

    (Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control (AEMPC), Collaborative Innovation Center of Atmospheric Environment and Equipment Technology (AEET), School of Environmental Science and Engineering, Nanjing University of Information Science & Technology (NUIST), Nanjing 210044, China)

  • Shaojuan Luo

    (School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China)

  • Yunfeng Gu

    (Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control (AEMPC), Collaborative Innovation Center of Atmospheric Environment and Equipment Technology (AEET), School of Environmental Science and Engineering, Nanjing University of Information Science & Technology (NUIST), Nanjing 210044, China)

  • Dongyang Nie

    (School of Atmospheric Sciences, Nanjing University, Nanjing 210023, China)

  • Zhiyang Xu

    (Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control (AEMPC), Collaborative Innovation Center of Atmospheric Environment and Equipment Technology (AEET), School of Environmental Science and Engineering, Nanjing University of Information Science & Technology (NUIST), Nanjing 210044, China)

  • Yue Wu

    (Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control (AEMPC), Collaborative Innovation Center of Atmospheric Environment and Equipment Technology (AEET), School of Environmental Science and Engineering, Nanjing University of Information Science & Technology (NUIST), Nanjing 210044, China)

  • Mindong Chen

    (Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control (AEMPC), Collaborative Innovation Center of Atmospheric Environment and Equipment Technology (AEET), School of Environmental Science and Engineering, Nanjing University of Information Science & Technology (NUIST), Nanjing 210044, China)

  • Xinlei Ge

    (Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control (AEMPC), Collaborative Innovation Center of Atmospheric Environment and Equipment Technology (AEET), School of Environmental Science and Engineering, Nanjing University of Information Science & Technology (NUIST), Nanjing 210044, China)

Abstract

Although nanoparticles (NPs) have been used as simplified atmospheric particulate matter (PM) models, little experimental evidence is available to support such simulations. In this study, we comparatively assessed the toxic effects of PM and typical NPs (four carbonaceous NPs with different morphologies, metal NPs of Fe, Al, and Ti, as well as SiO 2 NPs) on human lung epithelial A549 cells. The EC50 value of PM evaluated by cell viability assay was 148.7 μg/mL, closest to that of SiO 2 NPs, between the values of carbonaceous NPs and metal NPs. All particles caused varying degrees of reactive oxygen species (ROS) generation and adenosine triphosphate (ATP) suppression. TiO 2 NPs showed similar performance with PM in inducing ROS production ( p < 0.05). Small variations between two carbonaceous NPs (graphene oxides and graphenes) and PM were also observed at 50 μg/mL. Similarly, there was no significant difference in ATP inhibition between carbonaceous NPs and PM, while markedly different effects were caused by SiO 2 NP and TiO 2 NP exposure. Our results indicated that carbonaceous NPs could be served as potential surrogates for urban PM. The identification of PM model may help us further explore the specific roles and mechanisms of various components in PM.

Suggested Citation

  • Yun Wu & Mei Wang & Shaojuan Luo & Yunfeng Gu & Dongyang Nie & Zhiyang Xu & Yue Wu & Mindong Chen & Xinlei Ge, 2020. "Comparative Toxic Effects of Manufactured Nanoparticles and Atmospheric Particulate Matter in Human Lung Epithelial Cells," IJERPH, MDPI, vol. 18(1), pages 1-12, December.
    • Handle: RePEc:gam:jijerp:v:18:y:2020:i:1:p:22-:d:466564
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    References listed on IDEAS

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    1. Ao Di & Yun Wu & Mindong Chen & Dongyang Nie & Xinlei Ge, 2020. "Chemical Characterization of Seasonal PM 2.5 Samples and Their Cytotoxicity in Human Lung Epithelial Cells (A549)," IJERPH, MDPI, vol. 17(12), pages 1-13, June.
    2. Longfei Guan & Wei Rui & Ru Bai & Wei Zhang & Fang Zhang & Wenjun Ding, 2016. "Effects of Size-Fractionated Particulate Matter on Cellular Oxidant Radical Generation in Human Bronchial Epithelial BEAS-2B Cells," IJERPH, MDPI, vol. 13(5), pages 1-14, May.
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    Cited by:

    1. Xiaoning Wang & Yangyang Sun & Qian Wang & Fengying Liu & Weijie Yang & Xin Sui & Jun Yang & Minmin Zhang & Shuai Wang & Zhenyu Xiao & Yuan Luo & Yongan Wang & Tong Zhu, 2022. "Potential Common Mechanisms of Cytotoxicity Induced by Amide Herbicides via TRPA1 Channel Activation," IJERPH, MDPI, vol. 19(13), pages 1-18, June.

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    1. Ao Di & Yun Wu & Mindong Chen & Dongyang Nie & Xinlei Ge, 2020. "Chemical Characterization of Seasonal PM 2.5 Samples and Their Cytotoxicity in Human Lung Epithelial Cells (A549)," IJERPH, MDPI, vol. 17(12), pages 1-13, June.

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