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The Risk of Depression in Patients with Pemphigus: A Nationwide Cohort Study in Taiwan

Author

Listed:
  • Yi-Min Hsu

    (Department of Public Health, China Medical University, Taichung 40447, Taiwan
    Department of Nursing, China Medical University Hospital, Taichung 40447, Taiwan)

  • Hsin-Yu Fang

    (Department of dermatology, China Medical University Hospital, Taichung 40447, Taiwan)

  • Cheng-Li Lin

    (Management Office for Health Data, China Medical University Hospital, Taichung 40447, Taiwan)

  • Shwn-Huey Shieh

    (Department of Health Services Administration, China Medical University, Taichung 40447, Taiwan
    Department of Nursing, Asia University, Taichung 41354, Taiwan)

Abstract

Pemphigus is a chronic dermatological disorder caused by an autoimmune response and is associated with a high proportion of comorbidities and fatalities. The aim of this study was to investigate the risk of depression in patients with pemphigus. Data were derived from the National Health Insurance Research Database recorded during the period 2000–2010 in Taiwan. Multivariate Cox proportional hazards regression models were used to analyze the data and assess the effects of pemphigus on the risk of depression after adjusting for demographic characteristics and comorbidities. Patients with pemphigus were 1.98 times more likely to suffer from depression than the control group (pemphigus, adjusted HR: 1.99, 95% CI = 1.37–2.86). People aged ≥65 years were 1.69 times more likely to suffer from depression than those aged 20–49 years (≥65 years, adjusted HR: 1.42, 95% CI = 0.92–2.21). Female and male patients with pemphigus were respectively 2.02 and 1.91 times more likely to suffer from depression than the control group (female, adjusted HR: 2.09, 95% CI = 1.24–3.54; male, adjusted HR: 1.87, 95% CI = 0.97–3.60). People with HTN, hyperlipidemia, asthma/COPD, and chronic liver disease were respectively 1.73, 2.3, 2.2, and 1.69 times more likely to suffer from depression than those without these comorbidities (HTN, adjusted HR: 0.75, 95% CI = 0.41–1.42; hyperlipidemia, adjusted HR: 1.48, 95% CI = 0.78–2.82; asthma/COPD, adjusted HR: 1.4, 95% CI = 0.72–2.69; and chronic liver disease, adjusted HR: 1.61, 95% CI = 1.07–2.43). There was a significant association between pemphigus and increased risk of depression. Female patients had a higher incidence of depression.

Suggested Citation

  • Yi-Min Hsu & Hsin-Yu Fang & Cheng-Li Lin & Shwn-Huey Shieh, 2020. "The Risk of Depression in Patients with Pemphigus: A Nationwide Cohort Study in Taiwan," IJERPH, MDPI, vol. 17(6), pages 1-10, March.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:6:p:1983-:d:333629
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    Cited by:

    1. Chien-Lung Chan & Chi-Chang Chang, 2020. "Big Data, Decision Models, and Public Health," IJERPH, MDPI, vol. 17(18), pages 1-7, September.
    2. Chien-Lung Chan & Chi-Chang Chang, 2022. "Big Data, Decision Models, and Public Health," IJERPH, MDPI, vol. 19(14), pages 1-9, July.

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