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Long-Term Fipronil Treatment Induces Hyperactivity in Female Mice

Author

Listed:
  • Svenja Koslowski

    (Perha Pharmaceuticals & ManRos Therapeutics, Centre de Perharidy, 29680 Roscoff, Bretagne, France
    C.RIS Pharma, Parc Technopolitain, Atalante Saint Malo, 35400 Saint Malo, France)

  • Camille Latapy

    (C.RIS Pharma, Parc Technopolitain, Atalante Saint Malo, 35400 Saint Malo, France)

  • Pierrïck Auvray

    (C.RIS Pharma, Parc Technopolitain, Atalante Saint Malo, 35400 Saint Malo, France)

  • Marc Blondel

    (Université Brest, Inserm, EFS, UMR1078, GGB, F-29200 Brest, France
    Service de Génétique clinique et de Biologie de la reproduction, CHRU (Centre Hospitalier Régional et Universitaire), F-29200 Brest, France)

  • Laurent Meijer

    (Perha Pharmaceuticals & ManRos Therapeutics, Centre de Perharidy, 29680 Roscoff, Bretagne, France)

Abstract

Fipronil is an insecticide widely used for veterinary and agricultural purposes. While its insecticidal properties mostly rely on its high affinity antagonistic activity on insect γ aminobutyric acid (GABA) receptors, fipronil and its main metabolite fipronil sulfone nevertheless display non-negligible affinity for mammalian GABA A receptor. As several environmental toxicants have been shown to raise the risk of developing various neurodegenerative disorders, the aim of this study was to evaluate whether long-term low dose administration of fipronil could lead to cognitive deficiencies. Our results indicate that long-term fipronil treatment leads to behavioral perturbations in mice, indicating an accumulative effect of sustained exposure to low dose of fipronil. Although no memory impairment was observed during the course of our study, we noticed a significant hyperlocomotion behavior after 43 weeks of weekly fipronil administration, which is consistent with its direct effect on the GABAergic system.

Suggested Citation

  • Svenja Koslowski & Camille Latapy & Pierrïck Auvray & Marc Blondel & Laurent Meijer, 2020. "Long-Term Fipronil Treatment Induces Hyperactivity in Female Mice," IJERPH, MDPI, vol. 17(5), pages 1-22, February.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:5:p:1579-:d:326537
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    Citations

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    Cited by:

    1. Patharanun Toolkiattiwong & Noppol Arunrat & Sukanya Sereenonchai, 2023. "Environmental, Human and Ecotoxicological Impacts of Different Rice Cultivation Systems in Northern Thailand," IJERPH, MDPI, vol. 20(3), pages 1-18, February.
    2. H Turlewicz-Podbielska & CJ Kowalski & A Burmanczuk & A Vynjarska & J Wojciechowski & M Pomorska-Mol & M Rybska, 2022. "Tolerance of Biopronil Spot on® after repeated single- or multiple-dose topical treatments in dogs," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 67(8), pages 418-429.

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