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Tolerance of Biopronil Spot on® after repeated single- or multiple-dose topical treatments in dogs

Author

Listed:
  • H Turlewicz-Podbielska

    (Department of Preclinical Sciences and Infectious Diseases, Faculty of Veterinary Medicine and Animal Sciences, Poznań University of Life Sciences, Poznań, Poland)

  • CJ Kowalski

    (Department of Preclinical Veterinary Sciences, Faculty of Veterinary Medicine, University of Life Sciences, Lublin, Poland)

  • A Burmanczuk

    (Department of Preclinical Veterinary Sciences, Faculty of Veterinary Medicine, University of Life Sciences, Lublin, Poland)

  • A Vynjarska

    (Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies, Lviv, Lviv Oblast, Ukraine)

  • J Wojciechowski

    (VETPOL, Grudziadz, Poland)

  • M Pomorska-Mol

    (Department of Preclinical Sciences and Infectious Diseases, Faculty of Veterinary Medicine and Animal Sciences, Poznań University of Life Sciences, Poznań, Poland)

  • M Rybska

    (Department of Preclinical Sciences and Infectious Diseases, Faculty of Veterinary Medicine and Animal Sciences, Poznań University of Life Sciences, Poznań, Poland)

Abstract

A variety of toxic effects of fipronil (FIP), the active substance of Biopronil Spot on®, on animals and humans has been reported and raises the need to investigate the FIP toxic effects. The objectives of the study were the evaluation of the local and systemic tolerance of Biopronil Spot on® and the assessment of its influence on haematological and biochemical blood parameters after single and multiple topical treatment in dogs. Thirty-two mixed breed dogs were included in the study assessing the local and general tolerance of Biopronil Spot on® following single, triple and fivefold dose after spot-on multiple applications in dogs (on days 0, +28 and +56) at a dosage 134 mg for a dog weighing 10-20 kg and 268 mg for a dog weighing 21-40 kg. A physical examination and biochemical and haematological analyses were performed on the days of the study as follows: -14, -5, +3, +31, +59, +70. No visible pathological changes on the skin were observed. The biochemical and haematological indicators rarely exceeded the reference values. No influence of Biopronil Spot on® administered in single, triple and fivefold repeated doses on the assessed clinical, haematological and biochemical parameters in dogs was found under the conditions described in the study.

Suggested Citation

  • H Turlewicz-Podbielska & CJ Kowalski & A Burmanczuk & A Vynjarska & J Wojciechowski & M Pomorska-Mol & M Rybska, 2022. "Tolerance of Biopronil Spot on® after repeated single- or multiple-dose topical treatments in dogs," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 67(8), pages 418-429.
    • Handle: RePEc:caa:jnlvet:v:67:y:2022:i:8:id:6-2021-vetmed
    DOI: 10.17221/6/2021-VETMED
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    References listed on IDEAS

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    1. Svenja Koslowski & Camille Latapy & Pierrïck Auvray & Marc Blondel & Laurent Meijer, 2020. "Long-Term Fipronil Treatment Induces Hyperactivity in Female Mice," IJERPH, MDPI, vol. 17(5), pages 1-22, February.
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