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Interaction of the CMTM7 rs347134 Polymorphism with Dietary Patterns and the Risk of Obesity in Han Chinese Male Children

Author

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  • Qi Zhu

    (Department of Nutrition, School of Public Health, Fudan University, Shanghai 200032, China
    Department of Medicine, Nantong University Xinglin College, Nantong 226008, Jiangsu, China
    School of Public Health, Nantong University, Nantong 226019, Jiangsu, China
    These authors are co-first authors of the manuscript.)

  • Kun Xue

    (Department of Nutrition, School of Public Health, Fudan University, Shanghai 200032, China
    These authors are co-first authors of the manuscript.)

  • Hong Wei Guo

    (Department of Nutrition, School of Public Health, Fudan University, Shanghai 200032, China)

  • Fei Fei Deng

    (Department of Nutrition, School of Public Health, Fudan University, Shanghai 200032, China)

  • Yu Huan Yang

    (School of Public Health, Nantong University, Nantong 226019, Jiangsu, China)

Abstract

A genome-wide association study (GWAS) in the Han Chinese population had found that single nucleotide polymorphism (SNP) on the CMTM7 gene rs347134 was significantly associated with Body Mass Index (BMI). In the present study, the association of the rs347134 SNP with obesity and its interaction with dietary patterns (DPs) were explored in Han Chinese children. This cross-sectional study group included 1292 children, in whom obesity-related indicators were evaluated, the rs347134 SNP was genotyped by improved Multiple Ligase Detection Reaction (iMLDR), and the DPs were identified by principal component factor analysis. The GG genotype exhibited higher odds of general overweight/obesity ( P = 0.038) and central obesity ( P = 0.039) than AA + GA genotypes in boys. Four DPs of boys were identified: healthy balanced (HBDP), nuts and sweets-based (NSDP), animal food-based (AFDP), and wheaten and dairy-based (WDDP). Boys with the GG genotype were significantly more inclined to AFDP ( P = 0.028) and had a shorter sleep duration ( P = 0.031). Significant interactions were observed; boys with the GG genotype displayed a higher LDL in AFDP ( P = 0.031) and higher FBG in NSDP ( P = 0.038), respectively. Our findings indicate for the first time that the GG genotype of CMTM7 rs347134 is potentially a novel obesity risk factor for Han Chinese male children and is associated with dietary patterns more or less.

Suggested Citation

  • Qi Zhu & Kun Xue & Hong Wei Guo & Fei Fei Deng & Yu Huan Yang, 2020. "Interaction of the CMTM7 rs347134 Polymorphism with Dietary Patterns and the Risk of Obesity in Han Chinese Male Children," IJERPH, MDPI, vol. 17(5), pages 1-15, February.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:5:p:1515-:d:325464
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    References listed on IDEAS

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    1. Bo Xi & Giriraj R Chandak & Yue Shen & Qijuan Wang & Donghao Zhou, 2012. "Association between Common Polymorphism near the MC4R Gene and Obesity Risk: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(9), pages 1-7, September.
    2. Ruth S.M. Chan & Jean Woo, 2010. "Prevention of Overweight and Obesity: How Effective is the Current Public Health Approach," IJERPH, MDPI, vol. 7(3), pages 1-19, February.
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