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Assessing the Potential Impact of a Long-Acting Skin Disinfectant in the Prevention of Methicillin-Resistant Staphylococcus aureus Transmission

Author

Listed:
  • Christopher T. Short

    (Paul G. Allen School for Global Animal Health, Washington State University, Pullman, WA 99164, USA)

  • Matthew S. Mietchen

    (Paul G. Allen School for Global Animal Health, Washington State University, Pullman, WA 99164, USA)

  • Eric T. Lofgren

    (Paul G. Allen School for Global Animal Health, Washington State University, Pullman, WA 99164, USA)

Abstract

Healthcare-associated transmission of methicillin-resistant Staphylococcus aureus (MRSA) remains a persistent problem. The use of chlorhexidine gluconate (CHG) as a means of decolonizing patients, either through targeted decolonization or daily bathing, is frequently used to supplement other interventions. We explore the potential of a long-acting disinfectant with a persistent effect, immediate decolonizing action in the prevention of MRSA acquisition, and clinical illness and mortality in an 18-bed intensive care unit, based on a previous model. A scenario with no intervention is compared to CHG bathing, which decolonizes patients but provides no additional protection, and a hypothetical treatment that both decolonizes them and provides protection from subsequent colonization. The duration and effectiveness of this protection is varied to fully explore the potential utility of such a treatment. Increasing the effectiveness of the decolonizing agent reduces colonization, with a 10% increase resulting in a colonization rate ratio (RR) of 0.89 (95% CI: 0.89,0.90). Increasing the duration of protection results in a much more modest reduction, with a 12-hour increase in protection resulting in an RR of 0.99 (95% CI: 0.99, 0.99). There is little evidence of synergy between the two.

Suggested Citation

  • Christopher T. Short & Matthew S. Mietchen & Eric T. Lofgren, 2020. "Assessing the Potential Impact of a Long-Acting Skin Disinfectant in the Prevention of Methicillin-Resistant Staphylococcus aureus Transmission," IJERPH, MDPI, vol. 17(5), pages 1-8, February.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:5:p:1500-:d:325277
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    References listed on IDEAS

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    1. Timo R Maarleveld & Brett G Olivier & Frank J Bruggeman, 2013. "StochPy: A Comprehensive, User-Friendly Tool for Simulating Stochastic Biological Processes," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-10, November.
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