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The Association between Metabolically Healthy Obesity, Cardiovascular Disease, and All-Cause Mortality Risk in Asia: A Systematic Review and Meta-Analysis

Author

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  • Ming-Yuan Huang

    (Department of Family Medicine, Taipei MacKay Memorial Hospital, No. 92, Section 2, Zhongshan North Road, Taipei City 10449, Taiwan
    Department of Medicine, MacKay Medical College, No. 46, Sec. 3, Zhongzheng Rd., Sanzhi Dist., New Taipei City 25245, Taiwan
    Hospice and Palliative Care Center, MacKay Memorial Hospital, No. 45, Minsheng Rd., Tamsui District, New Taipei City 25160, Taiwan)

  • Mu-Yi Wang

    (Post Graduate Year, Taipei MacKay Memorial Hospital, No. 92, Section 2, Zhongshan North Road, Taipei City 10449, Taiwan)

  • Yu-Sheng Lin

    (Post Graduate Year, Taipei MacKay Memorial Hospital, No. 92, Section 2, Zhongshan North Road, Taipei City 10449, Taiwan)

  • Chien-Ju Lin

    (Department of Family Medicine, Hsinchu MacKay Memorial Hospital, No. 690, Section 2, Guangfu Road, East District, Hsinchu City 30071, Taiwan)

  • Kai Lo

    (Post Graduate Year, Taipei MacKay Memorial Hospital, No. 92, Section 2, Zhongshan North Road, Taipei City 10449, Taiwan)

  • I-Jen Chang

    (Post Graduate Year, Taipei MacKay Memorial Hospital, No. 92, Section 2, Zhongshan North Road, Taipei City 10449, Taiwan)

  • Ting-Yao Cheng

    (Post Graduate Year, Taipei MacKay Memorial Hospital, No. 92, Section 2, Zhongshan North Road, Taipei City 10449, Taiwan)

  • Szu-Ying Tsai

    (Department of Family Medicine, Taipei MacKay Memorial Hospital, No. 92, Section 2, Zhongshan North Road, Taipei City 10449, Taiwan)

  • Hsin-Hao Chen

    (Department of Medicine, MacKay Medical College, No. 46, Sec. 3, Zhongzheng Rd., Sanzhi Dist., New Taipei City 25245, Taiwan
    Department of Family Medicine, Hsinchu MacKay Memorial Hospital, No. 690, Section 2, Guangfu Road, East District, Hsinchu City 30071, Taiwan
    MacKay Junior College of Medicine, Nursing, and Management, No. 92, Shengjing Rd., Beitou Dist., Taipei City 11260, Taiwan)

  • Chien-Yu Lin

    (Department of Medicine, MacKay Medical College, No. 46, Sec. 3, Zhongzheng Rd., Sanzhi Dist., New Taipei City 25245, Taiwan
    Department of Pediatrics, Hsinchu MacKay Memorial Hospital, Hsinchu 30071, Taiwan)

  • Shu Jung Liu

    (Department of Medical Library, MacKay Memorial Hospital, No. 45, Minsheng Rd., Tamsui District, New Taipei City 25160, Taiwan)

  • Kuo-Liong Chien

    (Department of Internal Medicine, National Taiwan University Hospital, No. 7, Zhongshan S. Rd., Zhongzheng Dist., Taipei City 10002, Taiwan
    Institute of Epidemiology and Preventive Medicine, National Taiwan University, Room 517, No.17, Xu-Zhou Rd., Taipei City 10055, Taiwan)

  • Tzu-Lin Yeh

    (Department of Family Medicine, Hsinchu MacKay Memorial Hospital, No. 690, Section 2, Guangfu Road, East District, Hsinchu City 30071, Taiwan
    Institute of Epidemiology and Preventive Medicine, National Taiwan University, Room 517, No.17, Xu-Zhou Rd., Taipei City 10055, Taiwan)

Abstract

We investigated the association among metabolically healthy obesity (MHO), cardiovascular disease (CVD)risk, and all-cause mortality in the Asian population. We searched databases from inception to 16 November, 2019 and pooled data using a random-effects model. Subgroup analysis was conducted according to the following comparison groups: MHNW (without overweight or underweight participants) and MHNO (non-obese, including overweight and underweight participants). Nineteen studies were included. The mean Newcastle–Ottawa Scale score was 7.8. Participants with MHO had a significantly higher CVD risk (odds ratio (OR) = 1.36, 95% confidence interval (CI) = 1.13–1.63) and significantly lower risk of all-cause mortality (OR = 0.88, 95% CI = 0.78–1.00) than the comparison group. Subgroup analyses revealed participants with MHO had a significantly higher CVD risk than MHNW participants (OR = 1.61; 95% CI = 1.24–2.08; I 2 = 73%), but there was no significant difference compared with MHNO participants (OR, 1.04; 95% CI, 0.80–1.36; I 2 = 68%). Participants with MHO had a significantly lower risk of all-cause mortality (OR = 0.83; 95% CI = 0.78–0.88; I 2 = 9%) than MHNO participants, but a borderline significantly higher risk of all-cause mortality than MHNW participants (OR = 1.30; 95% CI = 0.99–1.72; I 2 = 0%). The CVD risk and all-cause mortality of the MHO group changed depending on the control group. Thus, future studies should select control groups carefully.

Suggested Citation

  • Ming-Yuan Huang & Mu-Yi Wang & Yu-Sheng Lin & Chien-Ju Lin & Kai Lo & I-Jen Chang & Ting-Yao Cheng & Szu-Ying Tsai & Hsin-Hao Chen & Chien-Yu Lin & Shu Jung Liu & Kuo-Liong Chien & Tzu-Lin Yeh, 2020. "The Association between Metabolically Healthy Obesity, Cardiovascular Disease, and All-Cause Mortality Risk in Asia: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 17(4), pages 1-11, February.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:4:p:1320-:d:322274
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    Cited by:

    1. Chien-Lung Chan & Chi-Chang Chang, 2020. "Big Data, Decision Models, and Public Health," IJERPH, MDPI, vol. 17(18), pages 1-7, September.
    2. Chien-Lung Chan & Chi-Chang Chang, 2022. "Big Data, Decision Models, and Public Health," IJERPH, MDPI, vol. 19(14), pages 1-9, July.

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