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Impact of Adverse Drug Reactions in Patients with End Stage Renal Disease in Greece

Author

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  • Marios Spanakis

    (Department of Nursing, Faculty of Health Sciences, Hellenic Mediterranean University, Estavromenos, GR-71140 Heraklion, Crete, Greece
    Computational BioMedicine Laboratory, Institute of Computer Science, Foundation for Research and Technology—Hellas (FORTH), GR-70013 Heraklion, Crete, Greece)

  • Marianna Roubedaki

    (Department of Nephrology, General Hospital of Chania, Meletiou Metaxaki 25, GR-73131 Chania, Crete, Greece)

  • Ioannis Tzanakis

    (Department of Nephrology, General Hospital of Chania, Meletiou Metaxaki 25, GR-73131 Chania, Crete, Greece)

  • Michail Zografakis-Sfakianakis

    (Department of Nursing, Faculty of Health Sciences, Hellenic Mediterranean University, Estavromenos, GR-71140 Heraklion, Crete, Greece)

  • Evridiki Patelarou

    (Department of Nursing, Faculty of Health Sciences, Hellenic Mediterranean University, Estavromenos, GR-71140 Heraklion, Crete, Greece)

  • Athina Patelarou

    (Department of Nursing, Faculty of Health Sciences, Hellenic Mediterranean University, Estavromenos, GR-71140 Heraklion, Crete, Greece)

Abstract

Background: Patients with end-stage renal disease (ESRD) require specialized therapeutic interventions. The decreased renal function that modulates the physiology and presence of comorbidities is often associated with variations in the pharmacological response, thus increasing the risk of adverse drug events or reactions (ADE/ADRs) from co-administered drugs. Methods: A cross-sectional study to record comorbidities, drug–drug interactions (DDIs), ADE/ADRs in patients with chronic kidney disease of stage five in Greece. The study enrolled 60 patients of mean age 64.8 ± 12.9 years, undergoing hemodialysis three times a week. Demographic and social factors, comorbidities, laboratory test data, medication regimens, DDIs and the reporting of ADE/ADRs were analyzed. Results: Cardiovascular diseases and diabetes were the main comorbidities. In total, 50 different DDIs of various clinical significance were identified. CNS, GI-track, and musculoskeletal-system-related ADE/ADRs were most often reported by patients. ADE/ADRs as clinical outcome from DDIs were associated in 64% of the total identified DDIs. There was a positive trend between number of medications, ADE/ADRs report and DDIs. Conclusions: The impact of ADE/ADRs in ESRD patients should be always considered. Guidelines as well as continuous training in the context of evidence-based clinical practice by healthcare personnel on therapy administration and prevention of adverse events are important.

Suggested Citation

  • Marios Spanakis & Marianna Roubedaki & Ioannis Tzanakis & Michail Zografakis-Sfakianakis & Evridiki Patelarou & Athina Patelarou, 2020. "Impact of Adverse Drug Reactions in Patients with End Stage Renal Disease in Greece," IJERPH, MDPI, vol. 17(23), pages 1-17, December.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:23:p:9101-:d:457585
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    Cited by:

    1. Marios Spanakis & Athina Patelarou & Evridiki Patelarou & Nikolaos Tzanakis, 2021. "Drug Interactions for Patients with Respiratory Diseases Receiving COVID-19 Emerged Treatments," IJERPH, MDPI, vol. 18(21), pages 1-22, November.

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