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Association between Organophosphate Pesticide Exposure and Insulin Resistance in Pesticide Sprayers and Nonfarmworkers

Author

Listed:
  • Mathuramat Seesen

    (Department of Community Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand)

  • Roberto G. Lucchini

    (School of Public Health, Florida International University, Miami, FL 33199, USA
    Occupational Medicine, University of Brescia, 25121 Brescia, Italy)

  • Somkiat Siriruttanapruk

    (Department of Disease Control, Ministry of Public Health, Nonthaburi 11000, Thailand)

  • Ratana Sapbamrer

    (Department of Community Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand)

  • Surat Hongsibsong

    (School of Health Science Research, Research Institute for Health Science, Chiang Mai University, Chiang Mai 50200, Thailand)

  • Susan Woskie

    (Department of Public Health, Zuckerberg College of Health Sciences, University of Massachusetts Lowell, Lowell, MA 01854, USA)

  • Pornpimol Kongtip

    (Department of Occupational Health and Safety, Faculty of Public Health, Mahidol University, Bangkok 10400, Thailand
    Center of Excellence on Environmental Health and Toxicology, Bangkok 10400, Thailand)

Abstract

Insulin resistance is a risk factor for various diseases. Chronic organophosphate exposure has been reported to be a cause of insulin resistance in animal models. This cross-sectional study aimed to evaluate the association between organophosphate exposure and insulin resistance in pesticide sprayers and nonfarmworkers. Participants aged 40–60 years, consisting of 150 pesticide sprayers and 150 nonfarmworkers, were interviewed and assessed for their homeostatic model assessment of insulin resistance (HOMA-IR) level. Organophosphate (OP) exposure was measured in 37 sprayers and 46 nonfarmworkers by first morning urinary dialkyl phosphate (DAP) metabolites. The DAP metabolite levels were not different in either group except for diethylthiophosphate (DETP; p = 0.03), which was higher in sprayers. No significant association was observed between DAP metabolite levels and HOMA-IR. Wearing a mask while handling pesticides was associated with lower dimethyl metabolites (95% CI = −11.10, −0.17). Work practices of reading pesticide labels (95% CI = −81.47, −14.99) and washing hands after mixing pesticide (95% CI = −39.97, −3.35) correlated with lower diethyl alkylphosphate level. Overall, we did not observe any association between OP exposure and insulin resistance in pesticide sprayers and the general population. However, personal protective equipment (PPE) utilization and work practice were associated with OP exposure level in sprayers.

Suggested Citation

  • Mathuramat Seesen & Roberto G. Lucchini & Somkiat Siriruttanapruk & Ratana Sapbamrer & Surat Hongsibsong & Susan Woskie & Pornpimol Kongtip, 2020. "Association between Organophosphate Pesticide Exposure and Insulin Resistance in Pesticide Sprayers and Nonfarmworkers," IJERPH, MDPI, vol. 17(21), pages 1-13, November.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:21:p:8140-:d:439789
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    References listed on IDEAS

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    1. Asa Bradman & Rosemary Castorina & Dana Boyd Barr & Jonathan Chevrier & Martha E. Harnly & Ellen A. Eisen & Thomas E. McKone & Kim Harley & Nina Holland & Brenda Eskenazi, 2011. "Determinants of Organophosphorus Pesticide Urinary Metabolite Levels in Young Children Living in an Agricultural Community," IJERPH, MDPI, vol. 8(4), pages 1-23, April.
    2. Dana Boyd Barr & Lee-Yang Wong & Roberto Bravo & Gayanga Weerasekera & Martins Odetokun & Paula Restrepo & Do-Gyun Kim & Carolina Fernandez & Ralph D. Whitehead Jr. & Jose Perez & Maribel Gallegos & B, 2011. "Urinary Concentrations of Dialkylphosphate Metabolites of Organophosphorus Pesticides: National Health and Nutrition Examination Survey 1999–2004," IJERPH, MDPI, vol. 8(8), pages 1-36, July.
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    Cited by:

    1. Meaza Gezu Shentema & Magne Bråtveit & Abera Kumie & Wakgari Deressa & Bente Elisabeth Moen, 2022. "Respiratory Health among Pesticide Sprayers at Flower Farms in Ethiopia," IJERPH, MDPI, vol. 19(12), pages 1-9, June.

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