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FGFR4 Gene Polymorphism Reduces the Risk of Distant Metastasis in Lung Adenocarcinoma in Taiwan

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  • Ju-Pi Li

    (School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Pediatrics, Chung Shan Medical University Hospital, Taichung 402, Taiwan
    These authors contributed equally to the work.)

  • Hsien-Cheng Huang

    (Department of Emergency Medicine, Kuang Tien General Hospital, Taichung 433, Taiwan
    These authors contributed equally to the work.)

  • Po-Jen Yang

    (School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Family and Community Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan
    Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan)

  • Chien-Yuan Chang

    (Petite Doris Clinic, Taichung 408, Taiwan)

  • Yu-Hua Chao

    (School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Pediatrics, Chung Shan Medical University Hospital, Taichung 402, Taiwan)

  • Thomas Chang-Yao Tsao

    (School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Division of Chest, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan)

  • Hsuan Huang

    (School of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung 402, Taiwan)

  • Yu-Ching Hung

    (School of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung 402, Taiwan)

  • Ming-Ju Hsieh

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Cancer Research Center, Changhua Christian Hospital, Changhua 500, Taiwan
    Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404, Taiwan)

  • Shun-Fa Yang

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan)

Abstract

Fibroblast growth factor receptor 4 ( FGFR4) is involved in multiple physiological and pathological processes. Several genetic variants of FGFR4 have been shown to be associated with tumor progression in many cancers. However, its association, such as genetic variants and expression levels, with lung cancer is controversial. The present study examined the relationship between four single-nucleotide polymorphisms (SNPs; rs2011077 T/C, rs351855 G/A, rs7708357 G/A, and rs1966265 A/G) of FGFR4 and the risk of lung adenocarcinoma with the epidermal growth factor receptor ( EGFR ) mutation status in a Taiwanese cohort. The results demonstrated that FGFR4 rs2011077 (odds ratio (OR) = 0.348, 95% confidence interval (CI) = 0.136–0.891, p = 0.024), and rs351855 (OR = 0.296, 95% CI = 0.116–0.751, p = 0.008) showed an inverse association with distant metastasis in wild-type EGFR lung adenocarcinoma. Furthermore, a database analysis using The Cancer Genome Atlas revealed that the higher FGFR4 expression level was correlated with poor survival rates in wild-type EGFR lung adenocarcinoma. In conclusion, the data suggest that FGFR4 SNPs may help in identifying patient subgroups at low-risk for tumor metastasis, among carriers of lung adenocarcinoma bearing wild-type EGFR .

Suggested Citation

  • Ju-Pi Li & Hsien-Cheng Huang & Po-Jen Yang & Chien-Yuan Chang & Yu-Hua Chao & Thomas Chang-Yao Tsao & Hsuan Huang & Yu-Ching Hung & Ming-Ju Hsieh & Shun-Fa Yang, 2020. "FGFR4 Gene Polymorphism Reduces the Risk of Distant Metastasis in Lung Adenocarcinoma in Taiwan," IJERPH, MDPI, vol. 17(16), pages 1-11, August.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:16:p:5694-:d:395577
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    References listed on IDEAS

    as
    1. Ming-Dow Tsay & Ming-Ju Hsieh & Chia-Yi Lee & Shian-Shiang Wang & Chuan-Shu Chen & Sheng-Chun Hung & Chia-Yen Lin & Shun-Fa Yang, 2019. "Involvement of FGFR4 Gene Variants on the Clinicopathological Severity in Urothelial Cell Carcinoma," IJERPH, MDPI, vol. 17(1), pages 1-9, December.
    2. Roberta Lelis Dutra & Marcos Brasilino de Carvalho & Marcelo dos Santos & Ana Maria da Cunha Mercante & Diana Gazito & Rafael de Cicco & GENCAPO Group & Eloiza Helena Tajara & Iúri Drumond Louro & Adr, 2012. "FGFR4 Profile as a Prognostic Marker in Squamous Cell Carcinoma of the Mouth and Oropharynx," PLOS ONE, Public Library of Science, vol. 7(11), pages 1-9, November.
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      Keywords

      lung cancer; FGFR4; polymorphism; EGFR mutation;
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