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Involvement of FGFR4 Gene Variants on the Clinicopathological Severity in Urothelial Cell Carcinoma

Author

Listed:
  • Ming-Dow Tsay

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Family medicine, Tungs’ Taichung MetroHarbor Hospital, Taichung 433, Taiwan
    These authors contributed equally to the work.)

  • Ming-Ju Hsieh

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Cancer Research Center, Changhua Christian Hospital, Changhua 500, Taiwan
    Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404, Taiwan
    These authors contributed equally to the work.)

  • Chia-Yi Lee

    (Department of Ophthalmology, Show Chwan Memorial Hospital, Changhua 500, Taiwan
    Department of Optometry, College of Medicine and Life Science, Chung Hwa University of Medical Technology, Tainan 717, Taiwan)

  • Shian-Shiang Wang

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Division of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung 407, Taiwan
    Department of Applied Chemistry, National Chi Nan University, Nantou 545, Taiwan)

  • Chuan-Shu Chen

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Division of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung 407, Taiwan)

  • Sheng-Chun Hung

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Division of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung 407, Taiwan)

  • Chia-Yen Lin

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Division of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung 407, Taiwan)

  • Shun-Fa Yang

    (Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan)

Abstract

Fibroblast growth factor receptor 4 (FGFR4) plays a prominent role in cell proliferation and cancer progression. This study explored the effect of FGFR4 single-nucleotide polymorphisms (SNPs) on the clinicopathological characteristics of urothelial cell carcinoma (UCC). This study was conducted to survey the possible correlation of the polymorphism of FGFR4 to the risk and clinicopathologic characteristics of UCC. Four loci of FGFR4 (rs2011077 T > C, rs351855 G > A, rs7708357 G>A, and rs1966265 A > G) were genotyped via the TaqMan allelic discrimination approach in 428 UCC cases and 856 controls. The results indicated that UCC subjects who carried the SNP rs2011077 TC+CC genotypes were significantly related to a higher tumor stage (odds ratio (OR): 1.751, 95% confidence interval (CI): 1.078–2.846), primary tumor size (OR: 1.637, 95% CI: 1.006–2.662), and histopathologic grading (OR: 1.919, 95% CI: 1.049–3.511). Moreover, the SNP rs1966265 AG+GG genotypes were prominently related to a higher tumor stage (OR: 1.769, 95% CI: 1.082–2.891), primary tumor size (OR: 1.654, 95% CI: 1.011–2.706), and histopathologic grading (OR: 2.006, 95% CI: 1.096–3.674) compared to individuals with AA homozygotes. In conclusion, our data reveal association of FGFR4 polymorphisms with UCC clinicopathologic characteristics. FGFR4 polymorphisms may serve as a marker or therapeutic target in UCC development.

Suggested Citation

  • Ming-Dow Tsay & Ming-Ju Hsieh & Chia-Yi Lee & Shian-Shiang Wang & Chuan-Shu Chen & Sheng-Chun Hung & Chia-Yen Lin & Shun-Fa Yang, 2019. "Involvement of FGFR4 Gene Variants on the Clinicopathological Severity in Urothelial Cell Carcinoma," IJERPH, MDPI, vol. 17(1), pages 1-9, December.
    • Handle: RePEc:gam:jijerp:v:17:y:2019:i:1:p:129-:d:301305
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    Citations

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    Cited by:

    1. Ju-Pi Li & Hsien-Cheng Huang & Po-Jen Yang & Chien-Yuan Chang & Yu-Hua Chao & Thomas Chang-Yao Tsao & Hsuan Huang & Yu-Ching Hung & Ming-Ju Hsieh & Shun-Fa Yang, 2020. "FGFR4 Gene Polymorphism Reduces the Risk of Distant Metastasis in Lung Adenocarcinoma in Taiwan," IJERPH, MDPI, vol. 17(16), pages 1-11, August.

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