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Quantitative Analysis of Effects of a Single 60 Co Gamma Ray Point Exposure on Time-Dependent Change in Locomotor Activity in Rats

Author

Listed:
  • Keiko Otani

    (The Center for Peace, Hiroshima University, Hiroshima 730-0053, Japan)

  • Megu Ohtaki

    (The Center for Peace, Hiroshima University, Hiroshima 730-0053, Japan)

  • Nariaki Fujimoto

    (Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8553, Japan)

  • Aisulu Saimova

    (Maxillo-facial and facial plastic surgery, Semey Medical University, Semey 071400, Kazakhstan)

  • Nailya Chaizhunusova

    (Public health, Medical University, Semey 071400, Kazakhstan)

  • Tolebay Rakhypbekov

    (Board of Directors, Astana Medical University, Astana 010000, Kazakhstan)

  • Hitoshi Sato

    (Radiological Sciences, Ibaraki Prefectural University of Health Sciences, Ibaraki 300-0394, Japan)

  • Noriyuki Kawano

    (The Center for Peace, Hiroshima University, Hiroshima 730-0053, Japan)

  • Masaharu Hoshi

    (The Center for Peace, Hiroshima University, Hiroshima 730-0053, Japan)

Abstract

Investigating initial behavioral changes caused by irradiation of animals might provide important information to aid understanding of early health effects of radiation exposure and clinical features of radiation injury. Although previous studies in rodents suggested that radiation exposure leads to reduced activity, detailed properties of the effects were unrevealed due to a lack of proper statistical analysis, which is needed to better elucidate details of changes in locomotor activity. Ten-week-old male Wistar rats were subjected to single point external whole-body irradiation with 60 Co gamma rays at 0, 2.0, 3.5, and 5.0 Gy (four rats per group). Infrared sensors were used to continuously record the locomotor activity of each rat. The cumulative number of movements during the night was defined as “activity” for each day. A non-linear mixed effects model accounting for individual differences and daily fluctuation of activity was applied to analyze the rats’ longitudinal locomotor data. Our statistical method revealed characteristics of the changes in locomotor activity after radiation exposure, showing that (1) reduction in activity occurred immediately—and in a dose-dependent manner—after irradiation and (2) recovery to pre-irradiation levels required almost one week, with the same recovery rate in each dose group.

Suggested Citation

  • Keiko Otani & Megu Ohtaki & Nariaki Fujimoto & Aisulu Saimova & Nailya Chaizhunusova & Tolebay Rakhypbekov & Hitoshi Sato & Noriyuki Kawano & Masaharu Hoshi, 2020. "Quantitative Analysis of Effects of a Single 60 Co Gamma Ray Point Exposure on Time-Dependent Change in Locomotor Activity in Rats," IJERPH, MDPI, vol. 17(16), pages 1-11, August.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:16:p:5638-:d:394711
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    References listed on IDEAS

    as
    1. Bates, Douglas & Mächler, Martin & Bolker, Ben & Walker, Steve, 2015. "Fitting Linear Mixed-Effects Models Using lme4," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 67(i01).
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