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Increased One-Year Recurrent Ischemic Stroke after First-Ever Ischemic Stroke in Males with Benign Prostatic Hyperplasia

Author

Listed:
  • Chun-Gu Cheng

    (Department of Emergency, Taoyuan Armed Forces General Hospital, Taoyuan 32549, National Defense Medical Center, Taipei 11490, Taiwan
    Department of Emergency Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan
    Department of Emergency and Critical Medicine, Wan Fang Hospital, Taipei Medical University, Taipei 11696, Taiwan)

  • Hsin Chu

    (Department of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan
    Institute of Aerospace and Undersea Medicine, National Defense Medical Center, Taipei 11490, Taiwan)

  • Jiunn-Tay Lee

    (Department of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan)

  • Wu-Chien Chien

    (Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan
    School of Public Health, National Defense Medical Center, Taipei 11490, Taiwan
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 11490, Taiwan)

  • Chun-An Cheng

    (Department of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan)

Abstract

(1) Background: Patients with benign prostatic hyperplasia (BPH) were questioned about quality of life and sleep. Most BPH patients were treated with alpha-1 adrenergic receptor antagonists, which could improve cerebral blood flow for 1–2 months. Patients with ischemic stroke (IS) could experience cerebral autoregulation impairment for six months. The relationship between BPH and recurrent IS remains unclear. The aim of this study was to determine the risk of one-year recurrent IS conferred by BPH. (2) Methods: We used data from the Taiwanese National Health Insurance Database to identify newly diagnosed IS cases entered from 1 January 2008 to 31 December 2008. Patients were followed until the recurrent IS event or 365 days after the first hospitalization. The risk factors associated with one-year recurrent IS were assessed using Cox proportional hazards regression. (3) Results: Patients with BPH had a higher risk of recurrent IS (12.11% versus 8.15%) (adjusted hazard ratio (HR): 1.352; 95% confidence interval (CI): 1.028–1.78, p = 0.031). Other risk factors included hyperlipidemia (adjusted HR: 1.338; 95% CI: 1.022–1.751, p = 0.034), coronary artery disease (adjusted HR: 1.487; 95% CI: 1.128–1.961, p = 0.005), chronic obstructive pulmonary disease (adjusted HR: 1.499; 95% CI: 1.075–2.091, p = 0.017), and chronic kidney disease (adjusted HR: 1.523; 95% CI: 1.033–2.244, p = 0.033). (4) Conclusion: Patients with BPH who had these risk factors had an increased risk of one-year recurrent IS. The modification of risk factors may prevent recurrent IS.

Suggested Citation

  • Chun-Gu Cheng & Hsin Chu & Jiunn-Tay Lee & Wu-Chien Chien & Chun-An Cheng, 2020. "Increased One-Year Recurrent Ischemic Stroke after First-Ever Ischemic Stroke in Males with Benign Prostatic Hyperplasia," IJERPH, MDPI, vol. 17(15), pages 1-10, July.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:15:p:5360-:d:389680
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    Cited by:

    1. Chien-Lung Chan & Chi-Chang Chang, 2020. "Big Data, Decision Models, and Public Health," IJERPH, MDPI, vol. 17(18), pages 1-7, September.
    2. Chien-Lung Chan & Chi-Chang Chang, 2022. "Big Data, Decision Models, and Public Health," IJERPH, MDPI, vol. 19(14), pages 1-9, July.

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