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Anti-Inflammatory and Antioxidative Potential of Aloe vera on the Cartap and Malathion Mediated Toxicity in Wistar Rats

Author

Listed:
  • Vivek Kumar Gupta

    (Department of Biochemistry, University of Allahabad, Prayagraj, U.P. 211002, India)

  • Abhishek Kumar

    (Department of Biochemistry, University of Allahabad, Prayagraj, U.P. 211002, India)

  • Maria de Lourdes Pereira

    (CICECO-Aveiro Institute of Materials & Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, Portugal)

  • Nikhat Jamal Siddiqi

    (FCSM-Department of Biochemistry, King Saud University, Riyadh 11495, Saudi Arabia)

  • Bechan Sharma

    (Department of Biochemistry, University of Allahabad, Prayagraj, U.P. 211002, India)

Abstract

Aloe vera has been the most useful medicinal herb in the world since ancient times due to its vast biological effects. The presence of high content of bioactive compounds make Aloe vera a promising complementary and alternative agent in disease prevention. The effectiveness of A. vera -based medicines against pesticide toxicity has never been evaluated. It was therefore envisaged to develop an A. vera -based strategy to protect the non-target animals from adverse effects of the pesticides. This article illustrates the ameliorating effect of aqueous extract (AE) of A. vera leaves against the cartap and malathion toxicity. To evaluate the protective impact of A. vera against cartap (Ctp), malathion (Mtn) and a mixture of both pesticides, the animals were divided in eight groups, each containing six rats: Group 1- C (control), Group 2- AE + C, Group 3- Ctp, Group 4- Mtn, Group 5- Ctp + Mtn, Group 6- AE + Ctp, Group 7- AE + Mtn, Group 8- AE + Ctp + Mtn. Wistar rats exposed to Ctp, Mtn and Ctp + Mtn, displayed significant change in body weight. It was observed that the WBC level increased significantly in Mtn and Ctp + Mtn challenged groups. The contents of TNF-α and IL-6 in serum increased expressively in the Ctp, Mtn and Ctp + Mtn challenged groups. Rats treated with Ctp, Mtn and Ctp + Mtn displayed significant alterations in the levels of antioxidative indices (MDA, GSH, GST, GPx, SOD and CAT). Significant alterations were recorded in the activities of AST, ALT, ACP and ALP in Ctp, Mtn and Ctp + Mtn challenged groups. The histopathological results of liver supported the biochemical data. The pre-treatment of rats with the aqueous extract of A. vera leaves significantly protected them from the toxicity of pesticides. These results suggested that A. vera extract may be used as a promising natural agent for the management of pesticide induced toxicity.

Suggested Citation

  • Vivek Kumar Gupta & Abhishek Kumar & Maria de Lourdes Pereira & Nikhat Jamal Siddiqi & Bechan Sharma, 2020. "Anti-Inflammatory and Antioxidative Potential of Aloe vera on the Cartap and Malathion Mediated Toxicity in Wistar Rats," IJERPH, MDPI, vol. 17(14), pages 1-19, July.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:14:p:5177-:d:386087
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    References listed on IDEAS

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    1. Hussein H. Mwanga & Mohamed Aqiel Dalvie & Tanusha S. Singh & Kalavati Channa & Mohamed F. Jeebhay, 2016. "Relationship between Pesticide Metabolites, Cytokine Patterns, and Asthma-Related Outcomes in Rural Women Workers," IJERPH, MDPI, vol. 13(10), pages 1-14, September.
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