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Association between Reflux Esophagitis Incidence and Palmar Hyperhidrosis

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  • Chun-Gu Cheng

    (Department of Emergency Medicine, Taoyuan Armed Forces General Hospital, National Defense Medical Center, Taoyuan 32549, Taiwan
    Department of Emergency and Critical Medicine, Wan Fang Hospital, Taipei Medical University, Taipei 11696, Taiwan
    Department of Emergency Medicine, Xin Tai General Hospital, New Taipei 24262, Taiwan)

  • Wu-Chien Chien

    (Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 11490, Taiwan
    Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan
    School of Public Health, National Defense Medical Center, Taipei 11490, Taiwan)

  • Chia-Peng Yu

    (School of Public Health, National Defense Medical Center, Taipei 11490, Taiwan)

  • Chi-Hsiang Chung

    (Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan
    School of Public Health, National Defense Medical Center, Taipei 11490, Taiwan)

  • Chun-An Cheng

    (Department of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan)

Abstract

The autonomic dysfunction in palmar hyperhidrosis (PH) includes not only sympathetic overactivity but also parasympathetic impairment. A decrease of parasympathetic tone has been noted in gastroesophageal reflux disease of neonates and adults. Patients with reflux esophagitis have a defective anti-reflux barrier. The association between reflux esophagitis and PH is deliberated in this article. The National Health Insurance Database in Taiwan was used. At first-time visits, PH patients were identified by the International Classification of Disease, 9th Revision, Clinical Modification disease code of 780.8 without endoscopic thoracic sympathectomy. Patients were matched by age and gender as control groups. The reflux esophagitis incidence was assessed using disease codes 530.11, 530.81, and 530.85. The factors related to reflux esophagitis were established by the Cox proportional regression model. The risk of reflux esophagitis in PH patients had a hazard ratio of 3.457 (95% confidence interval: 3.043–3.928) after adjustment of the other factors. We confirmed the association between reflux esophagitis and PH. Health care providers must be alerted to this relationship and other risk factors of reflux esophagitis to support suitable treatments to improve the quality of life of patients.

Suggested Citation

  • Chun-Gu Cheng & Wu-Chien Chien & Chia-Peng Yu & Chi-Hsiang Chung & Chun-An Cheng, 2020. "Association between Reflux Esophagitis Incidence and Palmar Hyperhidrosis," IJERPH, MDPI, vol. 17(12), pages 1-10, June.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:12:p:4502-:d:375167
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    References listed on IDEAS

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    1. Jae-Min Park & Duk Hwan Moon & Hye Sun Lee & Ju-young Park & Ji-Won Lee & Sungsoo Lee, 2019. "Hyperhidrosis, Endoscopic Thoracic Sympathectomy, and Cardiovascular Outcomes: A Cohort Study Based on the Korean Health Insurance Review and Assessment Service Database," IJERPH, MDPI, vol. 16(20), pages 1-11, October.
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    Cited by:

    1. Chien-Lung Chan & Chi-Chang Chang, 2020. "Big Data, Decision Models, and Public Health," IJERPH, MDPI, vol. 17(18), pages 1-7, September.
    2. Chien-Lung Chan & Chi-Chang Chang, 2022. "Big Data, Decision Models, and Public Health," IJERPH, MDPI, vol. 19(14), pages 1-9, July.
    3. Chun-An Cheng & Yu-Cheng Liang & Yin-Han Chang & Chun-Gu Cheng & Chi-Hsiang Chung & Wu-Chien Chien, 2021. "Increased Incidence of Premenstrual Syndrome in Females with Palmar Hyperhidrosis," IJERPH, MDPI, vol. 18(9), pages 1-11, April.

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    1. Chun-An Cheng & Yu-Cheng Liang & Yin-Han Chang & Chun-Gu Cheng & Chi-Hsiang Chung & Wu-Chien Chien, 2021. "Increased Incidence of Premenstrual Syndrome in Females with Palmar Hyperhidrosis," IJERPH, MDPI, vol. 18(9), pages 1-11, April.

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