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Quality of Life and Symptom Burden among Chronic Kidney Disease of Uncertain Etiology (CKDu) Patients in Girandurukotte, Sri Lanka

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  • Hansani Madushika Abeywickrama

    (Graduate School of Health Sciences, School of Health Sciences, Faculty of Medicine, Niigata University, 2-746, Asahimachi, Niigata 951-8518, Japan)

  • Swarna Wimalasiri

    (Department of Food Science and Technology, Faculty of Agriculture, University of Peradeniya, Kandy 20400, Sri Lanka)

  • Yu Koyama

    (Graduate School of Health Sciences, School of Health Sciences, Faculty of Medicine, Niigata University, 2-746, Asahimachi, Niigata 951-8518, Japan)

  • Mieko Uchiyama

    (Graduate School of Health Sciences, School of Health Sciences, Faculty of Medicine, Niigata University, 2-746, Asahimachi, Niigata 951-8518, Japan)

  • Utako Shimizu

    (Graduate School of Health Sciences, School of Health Sciences, Faculty of Medicine, Niigata University, 2-746, Asahimachi, Niigata 951-8518, Japan)

  • Nahoko Kakihara

    (Graduate School of Health Sciences, School of Health Sciences, Faculty of Medicine, Niigata University, 2-746, Asahimachi, Niigata 951-8518, Japan)

  • Rohana Chandrajith

    (Department of Geology, Faculty of Science, University of Peradeniya, Kandy 20400, Sri Lanka)

  • Nishantha Nanayakkara

    (Transplant and Dialysis Unit, Teaching Hospital, Kandy 20000, Sri Lanka)

Abstract

Symptom burden and health-related quality of life (HRQOL) are important predictors of how a disease affects patients’ lives, especially for endemic health problems such as chronic kidney disease of uncertain etiology (CKDu). Our study describes symptom burden, HRQOL, and associated demographic and clinical variables in CKDu patients in the Girandurukotte area, Sri Lanka. A cross-sectional study included 120 CKDu patients attending the renal clinic in the endemic area. The instruments applied were the Kidney Disease Quality of Life—Short Form (KDQOL-SF TM ) version 1.3 and CKD Symptom Index—Sri Lanka. Socio-demographic, disease-related, and anthropometric variables were also investigated. The mean age of patients was 61.87 (SD 11.31), while 69.2% were male. The mean glomerular filtration rate was 28.17 (SD 14.03) mL/min/1.73 min 2 , and 70.8% were anemic. Bone/joint pain was the most experienced symptom while the median number of symptoms reported by patients was 5 (IQR 3–7). The mean symptom burden, physical component summary, mental component summary, and kidney-disease-specific component scores were 12.71 (SD 10.45), 68.63 (SD 19.58), 78.53 (SD 18.78), and 81.57 (SD 5.86), respectively. Age was found to be a significant predictor of HRQOL, while hemoglobin level and being a farmer were significant predictors of symptom burden. Our data indicate that CKDu patients in all stages experience at least one symptom affecting all aspects of HRQOL.

Suggested Citation

  • Hansani Madushika Abeywickrama & Swarna Wimalasiri & Yu Koyama & Mieko Uchiyama & Utako Shimizu & Nahoko Kakihara & Rohana Chandrajith & Nishantha Nanayakkara, 2020. "Quality of Life and Symptom Burden among Chronic Kidney Disease of Uncertain Etiology (CKDu) Patients in Girandurukotte, Sri Lanka," IJERPH, MDPI, vol. 17(11), pages 1-16, June.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:11:p:4041-:d:367949
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    References listed on IDEAS

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    1. Channa Jayasumana & Sarath Gunatilake & Priyantha Senanayake, 2014. "Glyphosate, Hard Water and Nephrotoxic Metals: Are They the Culprits Behind the Epidemic of Chronic Kidney Disease of Unknown Etiology in Sri Lanka?," IJERPH, MDPI, vol. 11(2), pages 1-23, February.
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    1. Thalwaththe Gedara Nadeeka Shayamalie Gunarathne & Li Yoong Tang & Soo Kun Lim & Nishantha Nanayakkara & Hewaratne Dassanayakege Wimala Thushari Damayanthi & Khatijah L. Abdullah, 2022. "Factors Associated with Symptom Burden in Adults with Chronic Kidney Disease Undergoing Hemodialysis: A Prospective Study," IJERPH, MDPI, vol. 19(9), pages 1-13, May.
    2. I. D. U. H. Piyathilake & J. L. P. C. Randika & R. M. K. T. Rathnayaka & E. P. N. Udayakumara & L. V. Ranaweera & S. K. Gunatilake & C. B. Dissanayake, 2022. "Socio-economic determinants of Chronic Kidney Diseases of uncertain etiology (CKDu) in the Uva Province, Sri Lanka: a cross-sectional study," Journal of Environmental Studies and Sciences, Springer;Association of Environmental Studies and Sciences, vol. 12(4), pages 782-793, December.
    3. Khanh Vuong Diem Doan & Hien Thi Minh Nguyen & Nhi Thi Hong Nguyen & Khoa Cao Dang & Shwu-Huey Yang & Tuyen Van Duong, 2020. "Associations of Socio-Demographic, Clinical and Biochemical Parameters with Healthcare Cost, Health- and Renal-Related Quality of Life in Hemodialysis Patients: A Clinical Observational Study," IJERPH, MDPI, vol. 17(18), pages 1-15, September.

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