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The Oral NOAEL of Flurochloridone in Male Wistar Rats in Ninety-Day Subchronic Toxicity Test Was 3mg/kg/day

Author

Listed:
  • Hongyan Zhu

    (Pharmacology and Toxicology Department, Shanghai Institute for Food and Drug Control, Shanghai 201203, China)

  • Rui Li

    (Pharmacology and Toxicology Department, Shanghai Institute for Food and Drug Control, Shanghai 201203, China
    School of Public Health/MOE Key Laboratory for Public Health Safety/Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, Shanghai 200032, China)

  • Su Zhou

    (Pharmacology and Toxicology Department, Shanghai Institute for Food and Drug Control, Shanghai 201203, China)

  • Suhui Zhang

    (Pharmacology and Toxicology Department, Shanghai Institute for Food and Drug Control, Shanghai 201203, China)

  • Yu Wang

    (Pharmacology and Toxicology Department, Shanghai Institute for Food and Drug Control, Shanghai 201203, China)

  • Shihong Liu

    (School of Public Health/MOE Key Laboratory for Public Health Safety/Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, Shanghai 200032, China)

  • Qingwen Song

    (School of Public Health/MOE Key Laboratory for Public Health Safety/Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, Shanghai 200032, China)

  • Xiuli Chang

    (School of Public Health/MOE Key Laboratory for Public Health Safety/Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, Shanghai 200032, China)

  • Yubin Zhang

    (School of Public Health/MOE Key Laboratory for Public Health Safety/Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, Shanghai 200032, China)

  • Luqing Liu

    (School of Public Health/MOE Key Laboratory for Public Health Safety/Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, Shanghai 200032, China)

  • Liming Tang

    (Pharmacology and Toxicology Department, Shanghai Institute for Food and Drug Control, Shanghai 201203, China)

  • Zhijun Zhou

    (School of Public Health/MOE Key Laboratory for Public Health Safety/Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, Shanghai 200032, China)

Abstract

A ninety-day toxicity and toxicokinetics of flurochloridone (FLC) were studied in male Wistar rats with oral administration at doses of 3 mg/kg and 10 mg/kg respectively, following the previous study. Apparent toxicity to reproductive system of male rats was still observed at the dose of 10 mg/kg, trace amounts of FLC were still detected 24 hours after administration, testicular weight, epididymal weight and serum testosterone were significantly reduced and sperm abnormalities in epididymis were significantly increased. No abnormalities were found in 3 mg/kg group, it indicated that no-observed-adverse-effect level (NOAEL) of FLC in male rats was 3 mg/kg/day, far below the dose of 20 mg/kg/day reported by European Food Safety Authority (EFSA). Therefore, more attention should be paid to this herbicide.

Suggested Citation

  • Hongyan Zhu & Rui Li & Su Zhou & Suhui Zhang & Yu Wang & Shihong Liu & Qingwen Song & Xiuli Chang & Yubin Zhang & Luqing Liu & Liming Tang & Zhijun Zhou, 2019. "The Oral NOAEL of Flurochloridone in Male Wistar Rats in Ninety-Day Subchronic Toxicity Test Was 3mg/kg/day," IJERPH, MDPI, vol. 16(4), pages 1-7, February.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:4:p:553-:d:205940
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    References listed on IDEAS

    as
    1. Suhui Zhang & Xiaoqin Cheng & Yu Wang & Junpei Fan & Rui Li & Su Zhou & Shihong Liu & Jingmin Shi & Jie Sun & Yue Hu & Chaojin Xu & Chunhua Wu & Xiuli Chang & Liming Tang & Zhijun Zhou, 2015. "Ninety Day Toxicity and Toxicokinetics of Fluorochloridone after Oral Administration in Rats," IJERPH, MDPI, vol. 12(5), pages 1-25, May.
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    Cited by:

    1. Fen Zhang & Zhijing Ni & Shuqi Zhao & Yanna Wang & Xiuli Chang & Zhijun Zhou, 2022. "Flurochloridone Induced Cell Apoptosis via ER Stress and eIF2α-ATF4/ATF6-CHOP-Bim/Bax Signaling Pathways in Mouse TM4 Sertoli Cells," IJERPH, MDPI, vol. 19(8), pages 1-12, April.

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