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Comparing Quality of Life in Breast Cancer Patients Who Underwent Mastectomy Versus Breast-Conserving Surgery: A Meta-Analysis

Author

Listed:
  • Elvin T. Ng

    (Institute of Cognitive Neuroscience, Huaibei Normal University, Huaibei 235000, China
    Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore)

  • Russell Z. Ang

    (Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore)

  • Bach X. Tran

    (Institute for Preventive Medicine and Public Health, Hanoi Medical University, Hanoi 100000, Vietnam
    Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA)

  • Cyrus S. Ho

    (Department of Psychological Medicine, National University Hospital, Singapore 119228, Singapore)

  • Zhisong Zhang

    (Institute of Cognitive Neuroscience, Huaibei Normal University, Huaibei 235000, China
    Institute for Health Innovation and Technology (iHealthtech), National University of Singapore, Singapore 117599, Singapore)

  • Wanqiu Tan

    (Institute for Health Innovation and Technology (iHealthtech), National University of Singapore, Singapore 117599, Singapore
    The China-Singapore (Chongqing) Demonstration Initiative on Strategic Connectivity Think, Tank, Chongqing 400043, China)

  • Yu Bai

    (Institute of Cognitive Neuroscience, Huaibei Normal University, Huaibei 235000, China)

  • Min Zhang

    (Institute of Cognitive Neuroscience, Huaibei Normal University, Huaibei 235000, China)

  • Wilson W. Tam

    (Alice Lee School of Nursing, National University of Singapore, Singapore 117597, Singapore)

  • Roger C. Ho

    (Institute of Cognitive Neuroscience, Huaibei Normal University, Huaibei 235000, China
    Institute for Health Innovation and Technology (iHealthtech), National University of Singapore, Singapore 117599, Singapore
    Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore
    Centre of Excellence in Behavioral Medicine, Nguyen Tat Thanh University (NTTU), Ho Chi Minh City 70000, Vietnam)

Abstract

The purpose of our study was to carry out a meta-analysis of current literature to determine whether total mastectomy and breast-conserving surgery induce different outcomes in quality of life, based on the breast-cancer-specific module of the European Organizaation for Research and Treatment of Cancer core questionnaire (EORTC QLQ-BR23) used postoperatively. A systematic literature search of PubMed and EMBASE was conducted. Observational clinical studies that compared the quality of life in different surgery groups and presented empirical findings were selected. Six studies met the inclusion criteria. Breast-conserving surgery has statistically significant better outcomes than mastectomy in three of the eight outcomes measured in the EORTC QLQ-BR23, namely body image (standard mean difference, SMD = 1.742, 95% CI 0.579–2.905, p = 0.003), future perspective (SMD = 0.606, 95% CI 0.075–1.138, p = 0.025) and systemic therapy side effects (SMD = −0.641, 95% CI 0.101–1.181, p = 0.020). Our study highlighted that breast-conserving surgery was preferred over mastectomy because breast-conserving surgery leads to better outcomes in body image, future perspectives and less systemic side effects.

Suggested Citation

  • Elvin T. Ng & Russell Z. Ang & Bach X. Tran & Cyrus S. Ho & Zhisong Zhang & Wanqiu Tan & Yu Bai & Min Zhang & Wilson W. Tam & Roger C. Ho, 2019. "Comparing Quality of Life in Breast Cancer Patients Who Underwent Mastectomy Versus Breast-Conserving Surgery: A Meta-Analysis," IJERPH, MDPI, vol. 16(24), pages 1-10, December.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:24:p:4970-:d:295237
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    References listed on IDEAS

    as
    1. Edwin F. Liang & Samuel Z. Lim & Wilson W. Tam & Cyrus S. Ho & Melvyn W. Zhang & Roger S. McIntyre & Roger C. Ho, 2018. "The Effect of Methylphenidate and Atomoxetine on Heart Rate and Systolic Blood Pressure in Young People and Adults with Attention-Deficit Hyperactivity Disorder (ADHD): Systematic Review, Meta-Analysi," IJERPH, MDPI, vol. 15(8), pages 1-16, August.
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    Cited by:

    1. Małgorzata Socha & Krzysztof A. Sobiech, 2021. "Socio-Demographic and General Health Factors Associated with Quality of Life in Long-Term Breast Cancer Survivors from Southwestern Poland," IJERPH, MDPI, vol. 18(17), pages 1-15, September.
    2. Teresa Paolucci & Aristide Saggino & Francesco Agostini & Marco Paoloni & Andrea Bernetti & Massimiliano Mangone & Valter Santilli & Raoul Saggini & Marco Tommasi, 2021. "The Influence of Rehabilitation on Quality of Life in Breast Cancer Survivors: A Clinical Study," IJERPH, MDPI, vol. 18(16), pages 1-13, August.

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