IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v16y2019i22p4489-d286950.html
   My bibliography  Save this article

Quadrivalent Influenza Vaccine-Induced Antibody Response and Influencing Determinants in Patients ≥ 55 Years of Age in the 2018/2019 Season

Author

Listed:
  • Maria Ganczak

    (Department of Infectious Diseases, University of Zielona Góra, Zyty 28, 65-046 Zielona Góra, Poland
    Department of Epidemiology and Management. Pomeranian Medical University, Zolnierska 48, 71-210 Szczecin, Poland)

  • Paulina Dubiel

    (Department of Epidemiology and Management. Pomeranian Medical University, Zolnierska 48, 71-210 Szczecin, Poland)

  • Marzena Drozd-Dąbrowska

    (Department of Epidemiology and Management. Pomeranian Medical University, Zolnierska 48, 71-210 Szczecin, Poland)

  • Ewelina Hallmann-Szelińska

    (Department of Influenza Research, National Influenza Center, National Institute of Public Health–National Institute of Hygiene, Chocimska 24, 00-791 Warsaw, Poland)

  • Karol Szymański

    (Department of Influenza Research, National Influenza Center, National Institute of Public Health–National Institute of Hygiene, Chocimska 24, 00-791 Warsaw, Poland)

  • Lidia B. Brydak

    (Department of Influenza Research, National Influenza Center, National Institute of Public Health–National Institute of Hygiene, Chocimska 24, 00-791 Warsaw, Poland)

Abstract

The effects of immunization with subunit inactivated quadrivalent influenza vaccine (QIV) are not generally well assessed in the elderly Polish population. Therefore, this study evaluated vaccine-induced antibody response and its determinants. Methods: Consecutive patients ≥ 55 years old, attending a Primary Care Clinic in Gryfino, Poland, received QIV (A/Michigan/ 45/2015(H1N1)pdm09, A/Singapore/INFIMH-16-0019/2016 (H3N2), B/Colorado/06/2017, B/Phuket/ 3073/2013) between October-December 2018. Hemagglutination inhibition assays measured antibody response to vaccine strains from pre/postvaccination serum samples. Geometric mean titer ratio (GMTR), protection rate (PR) and seroconversion rate (SR) were also calculated. Results: For 108 patients (54.6% males, mean age: 66.7 years) the highest GMTR (61.5-fold) was observed for A/H3N2/, then B/Colorado/06/2017 (10.3-fold), A/H1N1/pdm09 (8.4-fold) and B/Phuket/ 3073/2013 (3.0-fold). Most patients had post-vaccination protection for A/H3N2/ and B/Phuket/3073/ 2013 (64.8% and 70.4%, respectively); lower PRs were observed for A/H1N1/pdm09 (41.8%) and B/Colorado/06/ 2017 (57.4%). The SRs for A/H3N2/, A/H1N1/pdm09, B Victoria and B Yamagata were 64.8%, 38.0%, 46.8%, and 48.2%, respectively. Patients who received QIV vaccination in the previous season presented lower ( p < 0.001 and p = 0.03, respectively) response to B Victoria and B Yamagata. Conclusions: QIV was immunogenic against the additional B lineage strain (B Victoria) without significantly compromising the immunogenicity of the other three vaccine strains, therefore, adding a second B lineage strain in QIV could broaden protection against influenza B infection in this age group. As the QIV immunogenicity differed regarding the four antigens, formulation adjustments to increase the antigen concentration of the serotypes that have lower immunogenicity could increase effectiveness. Prior season vaccination was associated with lower antibody response to a new vaccine, although not consistent through the vaccine strains.

Suggested Citation

  • Maria Ganczak & Paulina Dubiel & Marzena Drozd-Dąbrowska & Ewelina Hallmann-Szelińska & Karol Szymański & Lidia B. Brydak, 2019. "Quadrivalent Influenza Vaccine-Induced Antibody Response and Influencing Determinants in Patients ≥ 55 Years of Age in the 2018/2019 Season," IJERPH, MDPI, vol. 16(22), pages 1-15, November.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:22:p:4489-:d:286950
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/16/22/4489/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/16/22/4489/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Maria Ganczak & Karolina Gil & Marcin Korzeń & Marta Bażydło, 2017. "Coverage and Influencing Determinants of Influenza Vaccination in Elderly Patients in a Country with a Poor Vaccination Implementation," IJERPH, MDPI, vol. 14(6), pages 1-12, June.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Robert Susło & Piotr Pobrotyn & Lidia Brydak & Łukasz Rypicz & Urszula Grata-Borkowska & Jarosław Drobnik, 2021. "Seasonal Influenza and Low Flu Vaccination Coverage as Important Factors Modifying the Costs and Availability of Hospital Services in Poland: A Retrospective Comparative Study," IJERPH, MDPI, vol. 18(10), pages 1-15, May.
    2. Maria Ganczak & Paulina Dubiel & Marzena Drozd-Dąbrowska & Marcin Korzeń, 2022. "Does Vaccinating against Influenza in a Given Epidemic Season Have an Impact on Vaccination in the Next Season: A Follow-Up Study," IJERPH, MDPI, vol. 19(13), pages 1-11, June.
    3. Glen J. Nowak & Michael A. Cacciatore & María E. Len-Ríos, 2018. "Understanding and Increasing Influenza Vaccination Acceptance: Insights from a 2016 National Survey of U.S. Adults," IJERPH, MDPI, vol. 15(4), pages 1-19, April.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:16:y:2019:i:22:p:4489-:d:286950. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.