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Resveratrol Supplementation Protects against Nicotine-Induced Kidney Injury

Author

Listed:
  • Anand Ramalingam

    (Programme of Biomedical Science, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia)

  • Thulasiprevinnah Santhanathas

    (Programme of Biomedical Science, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia
    Institut Latihan Kementerian Kesihatan Malaysia, Jalan Pahang, Kuala Lumpur 50588, Malaysia)

  • Shafreena Shaukat Ali

    (Programme of Biomedical Science, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia)

  • Satirah Zainalabidin

    (Programme of Biomedical Science, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia)

Abstract

Prolonged exposure to nicotine accelerates onset and progression of renal diseases in habitual cigarette smokers. Exposure to nicotine, either via active or passive smoking is strongly shown to enhance renal oxidative stress and augment kidney failure in various animal models. In this study, we investigated the effects of resveratrol supplementation on nicotine-induced kidney injury and oxidative stress in a rat model. Male Sprague-Dawley rats were given nicotine (0.6 mg/kg, i.p.) alone or in combination with either resveratrol (8 mg/kg, i.p.), or angiotensin II type I receptor blocker, irbesartan (10 mg/kg, p.o.) for 28 days. Upon completion of treatment, kidneys were investigated for changes in structure, kidney injury markers and oxidative stress. Administration of nicotine alone for 28 days resulted in significant renal impairment as shown by marked increase in plasma creatinine, blood urea nitrogen (BUN) and oxidative stress. Co-administration with resveratrol however successfully attenuated these changes, with a concomitant increase in renal antioxidants such as glutathione similar to the conventionally used angiotensin II receptor blocker, irbesartan. These data altogether suggest that targeting renal oxidative stress with resveratrol could alleviate nicotine-induced renal injury. Antioxidants may be clinically important for management of renal function in habitual smokers.

Suggested Citation

  • Anand Ramalingam & Thulasiprevinnah Santhanathas & Shafreena Shaukat Ali & Satirah Zainalabidin, 2019. "Resveratrol Supplementation Protects against Nicotine-Induced Kidney Injury," IJERPH, MDPI, vol. 16(22), pages 1-13, November.
  • Handle: RePEc:gam:jijerp:v:16:y:2019:i:22:p:4445-:d:286272
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    Cited by:

    1. Naveed Ahmed & Sohaib Arshad & Syed Nahid Basheer & Mohmed Isaqali Karobari & Anand Marya & Charu Mohan Marya & Pratibha Taneja & Pietro Messina & Chan Yean Yean & Giuseppe Alessandro Scardina, 2021. "Smoking a Dangerous Addiction: A Systematic Review on an Underrated Risk Factor for Oral Diseases," IJERPH, MDPI, vol. 18(21), pages 1-16, October.

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