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Glycated Hemoglobin in the Diagnosis of Diabetes Mellitus in a Semi-Urban Brazilian Population

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  • Nayla Cristina do Vale Moreira

    (Institute of Health and Society, Department of Community Medicine and Global Health, University of Oslo (UiO), Oslo 0318, Norway
    Faculty of Medicine, Federal University of Ceará (FAMED-UFC), Fortaleza-Ceará 60020-181, Brazil)

  • Renan M. Montenegro

    (Faculty of Medicine, Federal University of Ceará (FAMED-UFC), Fortaleza-Ceará 60020-181, Brazil)

  • Haakon E. Meyer

    (Institute of Health and Society, Department of Community Medicine and Global Health, University of Oslo (UiO), Oslo 0318, Norway)

  • Bishwajit Bhowmik

    (Institute of Health and Society, Department of Community Medicine and Global Health, University of Oslo (UiO), Oslo 0318, Norway
    Centre for Global Health Research, Diabetic Association of Bangladesh, Dhaka 1000, Bangladesh)

  • Ibrahimu Mdala

    (Institute of Health and Society, Department of General Practice, University of Oslo (UiO), Oslo 0318, Norway)

  • Tasnima Siddiquee

    (Centre for Global Health Research, Diabetic Association of Bangladesh, Dhaka 1000, Bangladesh)

  • Virgínia Oliveira Fernandes

    (Faculty of Medicine, Federal University of Ceará (FAMED-UFC), Fortaleza-Ceará 60020-181, Brazil)

  • Akhtar Hussain

    (Faculty of Medicine, Federal University of Ceará (FAMED-UFC), Fortaleza-Ceará 60020-181, Brazil
    Centre for Global Health Research, Diabetic Association of Bangladesh, Dhaka 1000, Bangladesh
    Faculty of Health Sciences, Nord University, Bodø 8049, Norway)

Abstract

The study evaluated glycated hemoglobin (HbA1c) as a diagnostic tool for diabetes and pre-diabetes in the Brazilian population. Further, the homeostasis model assessment of insulin resistance (HOMA-IR) was also examined against HbA1c values to identify the most suitable cut-off points for HOMA-IR to predict the risk of diabetes. A cross-sectional study was conducted among 714 randomly selected subjects. HbA1c, fasting, and 2 h plasma glucose values were measured. Insulin resistance estimates were calculated with HOMA-IR. The receiver operating characteristic curve assessed HbA1c performance. The adjusted prevalence rate of diabetes mellitus was 14.7%, and pre-diabetes 14.2%. The optimal HbA1c cut-off value was ≥6.8% for the diagnosis of diabetes, and ≥6.0% for pre-diabetes. The area under the curve using HbA1c was 0.85 (95% CI: 0.80–0.90) for detecting diabetes and 0.61 (95% CI: 0.55–0.67) for pre-diabetes. The optimal HOMA-IR cut-off value was 2.06 for HbA1c at 6.8%. The HbA1c cut-off value of ≥6.8% may be suitable for diagnosing diabetes in the Brazilian population. Our results do not support the use of HbA1c to diagnose pre-diabetes. A HOMA-IR cut-off point of 2.06 was a sensitive marker to assess the risk of diabetes.

Suggested Citation

  • Nayla Cristina do Vale Moreira & Renan M. Montenegro & Haakon E. Meyer & Bishwajit Bhowmik & Ibrahimu Mdala & Tasnima Siddiquee & Virgínia Oliveira Fernandes & Akhtar Hussain, 2019. "Glycated Hemoglobin in the Diagnosis of Diabetes Mellitus in a Semi-Urban Brazilian Population," IJERPH, MDPI, vol. 16(19), pages 1-15, September.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:19:p:3598-:d:270828
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    Cited by:

    1. Wen Peng & Ke Li & Alice F. Yan & Zumin Shi & Junyi Zhang & Lawrence J. Cheskin & Ahktar Hussain & Youfa Wang, 2022. "Prevalence, Management, and Associated Factors of Obesity, Hypertension, and Diabetes in Tibetan Population Compared with China Overall," IJERPH, MDPI, vol. 19(14), pages 1-15, July.

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