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APOE Variant (rs405509) might Modulate the Effect of Sex and Educational Level on Cognitive Impairment Risk in a Taiwanese Population

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  • Tsui-Wen Hsu

    (Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
    Superintendent Office, Cathay General Hospital, Taipei 106, Taiwan)

  • Disline Manli Tantoh

    (Department of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung 40201, Taiwan)

  • Pang-Li Liu

    (Department of Medical Sociology and Social Work, Chung Shan Medical University, Taichung 40201, Taiwan)

  • Pei-Hsin Chen

    (Department of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung 40201, Taiwan)

  • Oswald Ndi Nfor

    (Department of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung 40201, Taiwan)

  • Ming-Chih Chou

    (Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
    School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan)

  • Long-Yau Lin

    (School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan)

  • Yung-Po Liaw

    (Department of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung 40201, Taiwan
    Department of Family and Community Medicine, Chung Shan Medical University Hospital, Taichung 40201, Taiwan)

Abstract

Education, sex, and the APOE-rs405509 variant are associated with Alzheimer’s disease and cognitive performance. We investigated if the rs405509 TT, TG, and GG genotypes modulate the effect of sex and education on cognitive impairment in Taiwanese adults. Data on cognitive health (defined by Mini-Mental State Examination (MMSE) scores) and rs405509 were from Taiwan Biobank. Participants included 2105 men and 2027 women with a mean age of 64 years. Education below university level was significantly associated with lower MMSE scores. The odds ratios (ORs) were 1.82; 95% confidence interval (CI) 1.38–2.41 for senior high school, 3.39; 95% CI 2.50–4.59 for junior high school, and 11.94; 95% CI 9.91–15.50 for elementary school and below ( p -trend < 0.05). The association between MMSE score and sex was significant only in the lowest educational group (elementary and below), with lower odds of having a low MMSE score in men compared to women (OR = 0.51; 95% CI 0.34–0.77). After stratification by rs405509 genotypes, this association was significant only among TT genotype carriers (OR = 0.481; CI = 0.253–0.915). In conclusion, a significant association between MMSE score and sex was observed in the lowest educational group, especially among carriers of rs405509 TT genotypes.

Suggested Citation

  • Tsui-Wen Hsu & Disline Manli Tantoh & Pang-Li Liu & Pei-Hsin Chen & Oswald Ndi Nfor & Ming-Chih Chou & Long-Yau Lin & Yung-Po Liaw, 2019. "APOE Variant (rs405509) might Modulate the Effect of Sex and Educational Level on Cognitive Impairment Risk in a Taiwanese Population," IJERPH, MDPI, vol. 16(10), pages 1-10, May.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:10:p:1732-:d:231753
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    1. Richard N. Jones & Joseph J. Gallo, 2002. "Education and Sex Differences in the Mini-Mental State Examination," The Journals of Gerontology: Series B, The Gerontological Society of America, vol. 57(6), pages 548-558.
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    Cited by:

    1. Chien-Lung Chan & Chi-Chang Chang, 2020. "Big Data, Decision Models, and Public Health," IJERPH, MDPI, vol. 17(18), pages 1-7, September.
    2. Chien-Lung Chan & Chi-Chang Chang, 2022. "Big Data, Decision Models, and Public Health," IJERPH, MDPI, vol. 19(14), pages 1-9, July.

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      Keywords

      education; sex; MMSE; APOE; rs405509;
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