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Prenatal Household Air Pollution Alters Cord Blood Mononuclear Cell Mitochondrial DNA Copy Number: Sex-Specific Associations

Author

Listed:
  • Seyram Kaali

    (Kintampo Health Research Centre, Ghana Health Service, Brong Ahafo Region, P. O. Box 200, Kintampo Ghana)

  • Darby W. Jack

    (Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY 10032, USA)

  • Rupert Delimini

    (Department of Biomedical Sciences, University of Health and Allied Sciences, P.O. Box 31, Ho, Ghana)

  • Lisa Hu

    (Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY 10032, USA)

  • Katrin Burkart

    (Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY 10032, USA)

  • Jones Opoku-Mensah

    (Kintampo Health Research Centre, Ghana Health Service, Brong Ahafo Region, P. O. Box 200, Kintampo Ghana)

  • Ashlinn Quinn

    (Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA)

  • Kenneth Ayuurebobi Ae-Ngibise

    (Kintampo Health Research Centre, Ghana Health Service, Brong Ahafo Region, P. O. Box 200, Kintampo Ghana)

  • Blair J. Wylie

    (Division of Maternal–fetal Medicine, Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA)

  • Ellen Abrafi Boamah-Kaali

    (Kintampo Health Research Centre, Ghana Health Service, Brong Ahafo Region, P. O. Box 200, Kintampo Ghana)

  • Steven Chillrud

    (Lamont-Doherty Earth Observatory at Columbia University, Palisades, NY 10964, USA)

  • Seth Owusu-Agyei

    (Kintampo Health Research Centre, Ghana Health Service, Brong Ahafo Region, P. O. Box 200, Kintampo Ghana
    Institute of Health Research, University of Health and Allied Sciences, PMB 31, Ho, Ghana)

  • Patrick L. Kinney

    (Department of Environmental Health, Boston University School of Public Health, Boston, MA 02118, USA)

  • Andrea A. Baccarelli

    (Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY 10032, USA)

  • Kwaku Poku Asante

    (Kintampo Health Research Centre, Ghana Health Service, Brong Ahafo Region, P. O. Box 200, Kintampo Ghana)

  • Alison Gladding Lee

    (Division of Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA)

Abstract

Background: Associations between prenatal household air pollution (HAP) exposure or cookstove intervention to reduce HAP and cord blood mononuclear cell (CBMC) mitochondrial deoxyribonucleic acid copy number (mtDNAcn), an oxidative stress biomarker, are unknown. Materials and Methods: Pregnant women were recruited and randomized to one of two cookstove interventions, including a clean-burning liquefied petroleum gas (LPG) stove, or control. Prenatal HAP exposure was determined by serial, personal carbon monoxide (CO) measurements. CBMC mtDNAcn was measured by quantitative polymerase chain reaction. Multivariable linear regression determined associations between prenatal CO and cookstove arm on mtDNAcn. Associations between mtDNAcn and birth outcomes and effect modification by infant sex were explored. Results: LPG users had the lowest CO exposures ( p = 0.02 by ANOVA). In boys only, average prenatal CO was inversely associated with mtDNAcn (β = -14.84, SE = 6.41, p = 0.03, per 1ppm increase in CO). When examined by study arm, LPG cookstove had the opposite effect in all children (LPG β = 19.34, SE = 9.72, p = 0.049), but especially boys (β = 30.65, SE = 14.46, p = 0.04), as compared to Control. Increased mtDNAcn was associated with improved birth outcomes. Conclusions: Increased prenatal HAP exposure reduces CBMC mtDNAcn, suggesting cumulative prenatal oxidative stress injury. An LPG stove intervention may reverse this effect. Boys appear most susceptible.

Suggested Citation

  • Seyram Kaali & Darby W. Jack & Rupert Delimini & Lisa Hu & Katrin Burkart & Jones Opoku-Mensah & Ashlinn Quinn & Kenneth Ayuurebobi Ae-Ngibise & Blair J. Wylie & Ellen Abrafi Boamah-Kaali & Steven Chi, 2018. "Prenatal Household Air Pollution Alters Cord Blood Mononuclear Cell Mitochondrial DNA Copy Number: Sex-Specific Associations," IJERPH, MDPI, vol. 16(1), pages 1-12, December.
    • Handle: RePEc:gam:jijerp:v:16:y:2018:i:1:p:26-:d:192630
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    References listed on IDEAS

    as
    1. Ezzati, Majid & Kammen, Daniel M., 2002. "The Health Impacts of Exposure to Indoor Air Pollution from Solid Fuels in Developing Countries: Knowledge, Gaps, and Data Needs," Discussion Papers 10864, Resources for the Future.
    2. Ezzati, Majid & Kammen, Daniel, 2002. "The Health Impacts of Exposure to Indoor Air Pollution from Solid Fuels in Developing Countries: Knowledge, Gaps, and Data Needs," RFF Working Paper Series dp-02-24, Resources for the Future.
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    1. Jonatan A. Mendoza-Ortega & Enrique Reyes-Muñoz & Sonia Nava-Salazar & Sandra Rodríguez-Martínez & Sandra B. Parra-Hernández & Lourdes Schnaas & Blanca Vianey Suárez-Rico & Libni A. Torres-Olascoaga &, 2021. "Mitochondrial DNA Copy Number Adaptation as a Biological Response Derived from an Earthquake at Intrauterine Stage," IJERPH, MDPI, vol. 18(22), pages 1-10, November.

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