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The Effect of Glyphosate on Human Sperm Motility and Sperm DNA Fragmentation

Author

Listed:
  • George Anifandis

    (Department of Obstetrics and Gynecology, ART Unit, School of Health Sciences, Faculty of Medicine, University of Thessaly, Larisa 41222, Greece)

  • Katerina Katsanaki

    (Department of Obstetrics and Gynecology, ART Unit, School of Health Sciences, Faculty of Medicine, University of Thessaly, Larisa 41222, Greece)

  • Georgia Lagodonti

    (Department of Obstetrics and Gynecology, ART Unit, School of Health Sciences, Faculty of Medicine, University of Thessaly, Larisa 41222, Greece)

  • Christina Messini

    (Department of Obstetrics and Gynecology, ART Unit, School of Health Sciences, Faculty of Medicine, University of Thessaly, Larisa 41222, Greece)

  • Mara Simopoulou

    (Department of Physiology, School of Health Sciences, Faculty of Medicine, Kapodistrian University of Athens, Athens 11225, Greece)

  • Konstantinos Dafopoulos

    (Department of Obstetrics and Gynecology, ART Unit, School of Health Sciences, Faculty of Medicine, University of Thessaly, Larisa 41222, Greece)

  • Alexandros Daponte

    (Department of Obstetrics and Gynecology, ART Unit, School of Health Sciences, Faculty of Medicine, University of Thessaly, Larisa 41222, Greece)

Abstract

Glyphosate is the active ingredient of Roundup ® , which is one of the most popular herbicides worldwide. Although many studies have focused on the reproductive toxicity of glyphosate or glyphosate-based herbicides, the majority of them have concluded that the effect of the specific herbicide is negligible, while only a few studies indicate the male reproductive toxicity of glyphosate alone. The aim of the present study was to investigate the effect of 0.36 mg/L glyphosate on sperm motility and sperm DNA fragmentation (SDF). Thirty healthy men volunteered to undergo semen analysis for the purpose of the study. Sperm motility was calculated according to WHO 2010 guidelines at collection time (zero time) and 1 h post-treatment with glyphosate. Sperm DNA fragmentation was evaluated with Halosperm ® G2 kit for both the control and glyphosate-treated sperm samples. Sperm progressive motility of glyphosate-treated samples was significantly reduced after 1 h post-treatment in comparison to the respective controls, in contrast to the SDF of glyphosate-treated samples, which was comparable to the respective controls. Conclusively, under these in vitro conditions, at high concentrations that greatly exceed environmental exposures, glyphosate exerts toxic effects on sperm progressive motility but not on sperm DNA integrity, meaning that the toxic effect is limited only to motility, at least in the first hour.

Suggested Citation

  • George Anifandis & Katerina Katsanaki & Georgia Lagodonti & Christina Messini & Mara Simopoulou & Konstantinos Dafopoulos & Alexandros Daponte, 2018. "The Effect of Glyphosate on Human Sperm Motility and Sperm DNA Fragmentation," IJERPH, MDPI, vol. 15(6), pages 1-8, May.
    • Handle: RePEc:gam:jijerp:v:15:y:2018:i:6:p:1117-:d:149739
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    Citations

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    Cited by:

    1. Yuan Meng & Ren Lin & Fengjuan Wu & Qi Sun & Lihong Jia, 2018. "Decreased Capacity for Sperm Production Induced by Perinatal Bisphenol A Exposure Is Associated with an Increased Inflammatory Response in the Offspring of C57BL/6 Male Mice," IJERPH, MDPI, vol. 15(10), pages 1-11, October.
    2. Yongsheng Fan & Guangxia Yu & Jun Yu & Jiantao Sun & Yu Wu & Xue Zhao & Yu Meng & Zhangdong He & Chunhong Wang, 2018. "Research Trends and Hotspots Analysis Related to the Effects of Xenobiotics on Glucose Metabolism in Male Testes," IJERPH, MDPI, vol. 15(8), pages 1-12, July.
    3. Simranjeet Singh & Vijay Kumar & Jatinder Pal Kaur Gill & Shivika Datta & Satyender Singh & Vaishali Dhaka & Dhriti Kapoor & Abdul Basit Wani & Daljeet Singh Dhanjal & Manoj Kumar & S. L. Harikumar & , 2020. "Herbicide Glyphosate: Toxicity and Microbial Degradation," IJERPH, MDPI, vol. 17(20), pages 1-18, October.
    4. Farren Hardneck & Charon de Villiers & Liana Maree, 2021. "Effect of Copper Sulphate and Cadmium Chloride on Non-Human Primate Sperm Function In Vitro," IJERPH, MDPI, vol. 18(12), pages 1-19, June.

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