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Integration of a Copper-Containing Biohybrid (CuHARS) with Cellulose for Subsequent Degradation and Biomedical Control

Author

Listed:
  • Anik Karan

    (Cellular Neuroscience Laboratory, Biomedical Engineering, College of Engineering and Science, Louisiana Tech University, Ruston, LA 71270, USA
    These authors contributed equally to this work.)

  • Margarita Darder

    (Materials Science Institute of Madrid (ICMM), CSIC, 28049 Madrid, Spain
    These authors contributed equally to this work.)

  • Urna Kansakar

    (Cellular Neuroscience Laboratory, Biomedical Engineering, College of Engineering and Science, Louisiana Tech University, Ruston, LA 71270, USA)

  • Zach Norcross

    (Cellular Neuroscience Laboratory, Biomedical Engineering, College of Engineering and Science, Louisiana Tech University, Ruston, LA 71270, USA)

  • Mark A. DeCoster

    (Cellular Neuroscience Laboratory, Biomedical Engineering, College of Engineering and Science, Louisiana Tech University, Ruston, LA 71270, USA
    Cellular Neuroscience Laboratory, Institute for Micromanufacturing, College of Engineering and Science, Louisiana Tech University, Ruston, LA 71270, USA)

Abstract

We previously described the novel synthesis of a copper high-aspect ratio structure (CuHARS) biohybrid material using cystine. While extremely stable in water, CuHARS is completely (but slowly) degradable in cellular media. Here, integration of the CuHARS into cellulose matrices was carried out to provide added control for CuHARS degradation. Synthesized CuHARS was concentrated by centrifugation and then dried. The weighed mass was re-suspended in water. CuHARS was stable in water for months without degradation. In contrast, 25 μg/mL of the CuHARS in complete cell culture media was completely degraded (slowly) in 18 days under physiological conditions. Stable integration of CuHARS into cellulose matrices was achieved through assembly by mixing cellulose micro- and nano-fibers and CuHARS in an aqueous (pulp mixture) phase, followed by drying. Additional materials were integrated to make the hybrids magnetically susceptible. The cellulose-CuHARS composite films could be transferred, weighed, and cut into usable pieces; they maintained their form after rehydration in water for at least 7 days and were compatible with cell culture studies using brain tumor (glioma) cells. These studies demonstrate utility of a CuHARS-cellulose biohybrid for applied applications including: (1) a platform for biomedical tracking and (2) integration into a 2D/3D matrix using natural products (cellulose).

Suggested Citation

  • Anik Karan & Margarita Darder & Urna Kansakar & Zach Norcross & Mark A. DeCoster, 2018. "Integration of a Copper-Containing Biohybrid (CuHARS) with Cellulose for Subsequent Degradation and Biomedical Control," IJERPH, MDPI, vol. 15(5), pages 1-12, April.
    • Handle: RePEc:gam:jijerp:v:15:y:2018:i:5:p:844-:d:143074
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    References listed on IDEAS

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    1. Peter J. Yunker & Tim Still & Matthew A. Lohr & A. G. Yodh, 2011. "Suppression of the coffee-ring effect by shape-dependent capillary interactions," Nature, Nature, vol. 476(7360), pages 308-311, August.
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