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Endocrine Disrupting Chemicals Mediated through Binding Androgen Receptor Are Associated with Diabetes Mellitus

Author

Listed:
  • Sugunadevi Sakkiah

    (National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA)

  • Tony Wang

    (Department of Biology, Arkansas University, Fayetteville, AR 72701, USA)

  • Wen Zou

    (National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA)

  • Yuping Wang

    (National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA)

  • Bohu Pan

    (National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA)

  • Weida Tong

    (National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA)

  • Huixiao Hong

    (National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA)

Abstract

Endocrine disrupting chemicals (EDCs) can mimic natural hormone to interact with receptors in the endocrine system and thus disrupt the functions of the endocrine system, raising concerns on the public health. In addition to disruption of the endocrine system, some EDCs have been found associated with many diseases such as breast cancer, prostate cancer, infertility, asthma, stroke, Alzheimer’s disease, obesity, and diabetes mellitus. EDCs that binding androgen receptor have been reported associated with diabetes mellitus in in vitro, animal, and clinical studies. In this review, we summarize the structural basis and interactions between androgen receptor and EDCs as well as the associations of various types of diabetes mellitus with the EDCs mediated through androgen receptor binding. We also discuss the perspective research for further understanding the impact and mechanisms of EDCs on the risk of diabetes mellitus.

Suggested Citation

  • Sugunadevi Sakkiah & Tony Wang & Wen Zou & Yuping Wang & Bohu Pan & Weida Tong & Huixiao Hong, 2017. "Endocrine Disrupting Chemicals Mediated through Binding Androgen Receptor Are Associated with Diabetes Mellitus," IJERPH, MDPI, vol. 15(1), pages 1-17, December.
    • Handle: RePEc:gam:jijerp:v:15:y:2017:i:1:p:25-:d:124139
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    References listed on IDEAS

    as
    1. Huixiao Hong & Diego Rua & Sugunadevi Sakkiah & Chandrabose Selvaraj & Weigong Ge & Weida Tong, 2016. "Consensus Modeling for Prediction of Estrogenic Activity of Ingredients Commonly Used in Sunscreen Products," IJERPH, MDPI, vol. 13(10), pages 1-17, September.
    2. Hui Wen Ng & Roger Perkins & Weida Tong & Huixiao Hong, 2014. "Versatility or Promiscuity: The Estrogen Receptors, Control of Ligand Selectivity and an Update on Subtype Selective Ligands," IJERPH, MDPI, vol. 11(9), pages 1-34, August.
    3. Huixiao Hong & Jie Shen & Hui Wen Ng & Sugunadevi Sakkiah & Hao Ye & Weigong Ge & Ping Gong & Wenming Xiao & Weida Tong, 2016. "A Rat α-Fetoprotein Binding Activity Prediction Model to Facilitate Assessment of the Endocrine Disruption Potential of Environmental Chemicals," IJERPH, MDPI, vol. 13(4), pages 1-18, March.
    4. Huixiao Hong & Benjamin G. Harvey & Giuseppe R. Palmese & Joseph F. Stanzione & Hui Wen Ng & Sugunadevi Sakkiah & Weida Tong & Joshua M. Sadler, 2016. "Experimental Data Extraction and in Silico Prediction of the Estrogenic Activity of Renewable Replacements for Bisphenol A," IJERPH, MDPI, vol. 13(7), pages 1-16, July.
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