IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v15y2017i1p25-d124139.html
   My bibliography  Save this article

Endocrine Disrupting Chemicals Mediated through Binding Androgen Receptor Are Associated with Diabetes Mellitus

Author

Listed:
  • Sugunadevi Sakkiah

    (National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA)

  • Tony Wang

    (Department of Biology, Arkansas University, Fayetteville, AR 72701, USA)

  • Wen Zou

    (National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA)

  • Yuping Wang

    (National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA)

  • Bohu Pan

    (National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA)

  • Weida Tong

    (National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA)

  • Huixiao Hong

    (National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA)

Abstract

Endocrine disrupting chemicals (EDCs) can mimic natural hormone to interact with receptors in the endocrine system and thus disrupt the functions of the endocrine system, raising concerns on the public health. In addition to disruption of the endocrine system, some EDCs have been found associated with many diseases such as breast cancer, prostate cancer, infertility, asthma, stroke, Alzheimer’s disease, obesity, and diabetes mellitus. EDCs that binding androgen receptor have been reported associated with diabetes mellitus in in vitro, animal, and clinical studies. In this review, we summarize the structural basis and interactions between androgen receptor and EDCs as well as the associations of various types of diabetes mellitus with the EDCs mediated through androgen receptor binding. We also discuss the perspective research for further understanding the impact and mechanisms of EDCs on the risk of diabetes mellitus.

Suggested Citation

  • Sugunadevi Sakkiah & Tony Wang & Wen Zou & Yuping Wang & Bohu Pan & Weida Tong & Huixiao Hong, 2017. "Endocrine Disrupting Chemicals Mediated through Binding Androgen Receptor Are Associated with Diabetes Mellitus," IJERPH, MDPI, vol. 15(1), pages 1-17, December.
    • Handle: RePEc:gam:jijerp:v:15:y:2017:i:1:p:25-:d:124139
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/15/1/25/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/15/1/25/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Huixiao Hong & Benjamin G. Harvey & Giuseppe R. Palmese & Joseph F. Stanzione & Hui Wen Ng & Sugunadevi Sakkiah & Weida Tong & Joshua M. Sadler, 2016. "Experimental Data Extraction and in Silico Prediction of the Estrogenic Activity of Renewable Replacements for Bisphenol A," IJERPH, MDPI, vol. 13(7), pages 1-16, July.
    2. Huixiao Hong & Diego Rua & Sugunadevi Sakkiah & Chandrabose Selvaraj & Weigong Ge & Weida Tong, 2016. "Consensus Modeling for Prediction of Estrogenic Activity of Ingredients Commonly Used in Sunscreen Products," IJERPH, MDPI, vol. 13(10), pages 1-17, September.
    3. Hui Wen Ng & Roger Perkins & Weida Tong & Huixiao Hong, 2014. "Versatility or Promiscuity: The Estrogen Receptors, Control of Ligand Selectivity and an Update on Subtype Selective Ligands," IJERPH, MDPI, vol. 11(9), pages 1-34, August.
    4. Huixiao Hong & Jie Shen & Hui Wen Ng & Sugunadevi Sakkiah & Hao Ye & Weigong Ge & Ping Gong & Wenming Xiao & Weida Tong, 2016. "A Rat α-Fetoprotein Binding Activity Prediction Model to Facilitate Assessment of the Endocrine Disruption Potential of Environmental Chemicals," IJERPH, MDPI, vol. 13(4), pages 1-18, March.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Huixiao Hong & Diego Rua & Sugunadevi Sakkiah & Chandrabose Selvaraj & Weigong Ge & Weida Tong, 2016. "Consensus Modeling for Prediction of Estrogenic Activity of Ingredients Commonly Used in Sunscreen Products," IJERPH, MDPI, vol. 13(10), pages 1-17, September.
    2. Huixiao Hong & Benjamin G. Harvey & Giuseppe R. Palmese & Joseph F. Stanzione & Hui Wen Ng & Sugunadevi Sakkiah & Weida Tong & Joshua M. Sadler, 2016. "Experimental Data Extraction and in Silico Prediction of the Estrogenic Activity of Renewable Replacements for Bisphenol A," IJERPH, MDPI, vol. 13(7), pages 1-16, July.
    3. Helena Pinos & Beatriz Carrillo & Ana Merchán & Judit Biosca-Brull & Cristian Pérez-Fernández & María Teresa Colomina & Fernando Sánchez-Santed & Fernando Martín-Sánchez & Paloma Collado & Jorge L. Ar, 2021. "Relationship between Prenatal or Postnatal Exposure to Pesticides and Obesity: A Systematic Review," IJERPH, MDPI, vol. 18(13), pages 1-24, July.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:15:y:2017:i:1:p:25-:d:124139. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.