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Incidence of Breast, Prostate, Testicular, and Thyroid Cancer in Italian Contaminated Sites with Presence of Substances with Endocrine Disrupting Properties

Author

Listed:
  • Marta Benedetti

    (Department of Environment and Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy)

  • Amerigo Zona

    (Department of Environment and Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy)

  • Eleonora Beccaloni

    (Department of Environment and Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy)

  • Mario Carere

    (Department of Environment and Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy)

  • Pietro Comba

    (Department of Environment and Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy)

Abstract

The aim of the present study was to investigate the incidence of breast (females), prostate, testicular, and thyroid cancer in the Italian National Priority Contaminated Sites (NPCSs), served by cancer registries, where the presence of endocrine disruptors (EDs), reported to be linked to these tumours, was documented. Evidence of carcinogenicity of EDs present in NPCSs was assessed based on evaluation by international scientific institutions and committees. Standardized Incidence Ratios (SIRs) were computed for each NPCS and cancer site between 1996 and 2005. Excess incidence of one or more cancer site studied was found in twelve out of fourteen NPCSs. Significantly increased SIRs were found for breast cancer in eight NPCSs, for prostate cancer in six, for thyroid cancer (both gender) in four, and for testicular cancer in two. Non-significantly increased SIRs were found in five NPCSs for testicular cancer and in two for thyroid cancer (males). In a small number of instances a significant deficit was reported, mainly for thyroid and prostate cancer. Although increased incidence of one or more cancer sites studied were found in several NPCSs, the ecological study design and the multifactorial aetiology of the considered tumours do not permit concluding causal links with environmental contamination. Regarding the observation of some excesses in SIRs, continuing epidemiological surveillance is warranted.

Suggested Citation

  • Marta Benedetti & Amerigo Zona & Eleonora Beccaloni & Mario Carere & Pietro Comba, 2017. "Incidence of Breast, Prostate, Testicular, and Thyroid Cancer in Italian Contaminated Sites with Presence of Substances with Endocrine Disrupting Properties," IJERPH, MDPI, vol. 14(4), pages 1-11, March.
    • Handle: RePEc:gam:jijerp:v:14:y:2017:i:4:p:355-:d:94438
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    Citations

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    Cited by:

    1. Maria De Falco & Vincenza Laforgia, 2021. "Combined Effects of Different Endocrine-Disrupting Chemicals (EDCs) on Prostate Gland," IJERPH, MDPI, vol. 18(18), pages 1-18, September.
    2. Francesca Gorini & Giorgio Iervasi & Alessio Coi & Letizia Pitto & Fabrizio Bianchi, 2018. "The Role of Polybrominated Diphenyl Ethers in Thyroid Carcinogenesis: Is It a Weak Hypothesis or a Hidden Reality? From Facts to New Perspectives," IJERPH, MDPI, vol. 15(9), pages 1-24, August.
    3. Marta Benedetti & Amerigo Zona & Paolo Contiero & Eleonora D’Armiento & Ivano Iavarone & AIRTUM Working Group, 2020. "Incidence of Thyroid Cancer in Italian Contaminated Sites," IJERPH, MDPI, vol. 18(1), pages 1-16, December.

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