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Determinants of Quality of Life in High-Dose Benzodiazepine Misusers

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  • Stefano Tamburin

    (Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Piazzale Scuro 10, Verona 37134, Italy)

  • Angela Federico

    (Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Piazzale Scuro 10, Verona 37134, Italy)

  • Marco Faccini

    (Department of Internal Medicine, Addiction Unit, Verona University Hospital, Piazzale Scuro 10, Verona 37134, Italy)

  • Rebecca Casari

    (Department of Internal Medicine, Addiction Unit, Verona University Hospital, Piazzale Scuro 10, Verona 37134, Italy)

  • Laura Morbioli

    (Department of Internal Medicine, Addiction Unit, Verona University Hospital, Piazzale Scuro 10, Verona 37134, Italy)

  • Valentina Sartore

    (Department of Internal Medicine, Addiction Unit, Verona University Hospital, Piazzale Scuro 10, Verona 37134, Italy)

  • Antonio Mirijello

    (Alcohol Use Disorders Unit, Department of Internal Medicine, Gastroenterology and Hepatology, Catholic University of Rome, Rome 00168, Italy)

  • Giovanni Addolorato

    (Alcohol Use Disorders Unit, Department of Internal Medicine, Gastroenterology and Hepatology, Catholic University of Rome, Rome 00168, Italy)

  • Fabio Lugoboni

    (Department of Internal Medicine, Addiction Unit, Verona University Hospital, Piazzale Scuro 10, Verona 37134, Italy)

Abstract

Benzodiazepines (BZDs) are among the most widely prescribed drugs in developed countries, but they have a high potential for tolerance, dependence and misuse. High-dose BZD misuse represents an emerging addiction phenomenon, but data on quality of life (QoL) in high-dose BZD misusers are scant. This study aimed to explore QoL in high-dose BZD misuse. We recruited 267 high-dose BZD misusers, compared the QoL scores in those who took BZD only to poly-drug misusers, and explored the role of demographic and clinical covariates through multivariable analysis. Our data confirmed worse QoL in high-dose BZD misusers and showed that (a) QoL scores were not negatively influenced by the misuse of alcohol or other drugs, or by coexisting psychiatric disorders; (b) demographic variables turned out to be the most significant predictors of QoL scores; (c) BZD intake significantly and negatively influenced QoL. Physical and psychological dimensions of QoL are significantly lower in high-dose BZD misusers with no significant effect of comorbidities. Our data suggest that the main reason for poor QoL in these patients is high-dose BZD intake per se. QoL should be considered among outcome measures in these patients.

Suggested Citation

  • Stefano Tamburin & Angela Federico & Marco Faccini & Rebecca Casari & Laura Morbioli & Valentina Sartore & Antonio Mirijello & Giovanni Addolorato & Fabio Lugoboni, 2017. "Determinants of Quality of Life in High-Dose Benzodiazepine Misusers," IJERPH, MDPI, vol. 14(1), pages 1-11, January.
    • Handle: RePEc:gam:jijerp:v:14:y:2017:i:1:p:38-:d:86858
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    References listed on IDEAS

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    1. Wenjun Cao & Chongzheng Guo & Weiwei Ping & Zhijun Tan & Ying Guo & Jianzhong Zheng, 2016. "A Community-Based Study of Quality of Life and Depression among Older Adults," IJERPH, MDPI, vol. 13(7), pages 1-10, July.
    2. Sylwia Wieder-Huszla & Małgorzata Szkup & Anna Jurczak & Agnieszka Samochowiec & Jerzy Samochowiec & Marzanna Stanisławska & Iwona Rotter & Beata Karakiewicz & Elżbieta Grochans, 2014. "Effects of Socio-Demographic, Personality and Medical Factors on Quality of Life of Postmenopausal Women," IJERPH, MDPI, vol. 11(7), pages 1-17, June.
    3. Amélie Prigent & Ane Auraaen & Blaise Kamendje-Tchokobou & Isabelle Durand-Zaleski & Karine Chevreul, 2014. "Health-Related Quality of Life and Utility Scores in People with Mental Disorders: A Comparison with the Non-Mentally Ill General Population," IJERPH, MDPI, vol. 11(3), pages 1-14, March.
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