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Effects of 1.8 GHz Radiofrequency Fields on the Emotional Behavior and Spatial Memory of Adolescent Mice

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  • Jun-Ping Zhang

    (Department of Radiation Biology, Faculty of Preventive Medicine, Fourth Military Medical University, 169# Chang Le West Road, Xi’an 710032, China
    These authors contributed equally to the work.)

  • Ke-Ying Zhang

    (Department of Radiation Biology, Faculty of Preventive Medicine, Fourth Military Medical University, 169# Chang Le West Road, Xi’an 710032, China
    These authors contributed equally to the work.)

  • Ling Guo

    (Department of Radiation Biology, Faculty of Preventive Medicine, Fourth Military Medical University, 169# Chang Le West Road, Xi’an 710032, China)

  • Qi-Liang Chen

    (Department of Radiation Biology, Faculty of Preventive Medicine, Fourth Military Medical University, 169# Chang Le West Road, Xi’an 710032, China)

  • Peng Gao

    (Department of Radiation Medicine, Faculty of Preventive Medicine, Fourth Military Medical University, 169# Chang Le West Road, Xi’an 710032, China)

  • Tian Wang

    (Department of Radiation Biology, Faculty of Preventive Medicine, Fourth Military Medical University, 169# Chang Le West Road, Xi’an 710032, China)

  • Jing Li

    (Department of Radiation Biology, Faculty of Preventive Medicine, Fourth Military Medical University, 169# Chang Le West Road, Xi’an 710032, China)

  • Guo-Zhen Guo

    (Department of Radiation Medicine, Faculty of Preventive Medicine, Fourth Military Medical University, 169# Chang Le West Road, Xi’an 710032, China)

  • Gui-Rong Ding

    (Department of Radiation Biology, Faculty of Preventive Medicine, Fourth Military Medical University, 169# Chang Le West Road, Xi’an 710032, China)

Abstract

The increasing use of mobile phones by teenagers has raised concern about the cognitive effects of radiofrequency (RF) fields. In this study, we investigated the effects of 4-week exposure to a 1.8 GHz RF field on the emotional behavior and spatial memory of adolescent male mice. Anxiety-like behavior was evaluated by open field test (OFT) and elevated plus maze (EPM) test, while depression-like behavior was evaluated by sucrose preference test (SPT), tail suspension test (TST) and forced swim test (FST). The spatial learning and memory ability were evaluated by Morris water maze (MWM) experiments. The levels of amino acid neurotransmitters were determined by liquid chromatography-mass spectrometry (LC-MS). The histology of the brain was examined by hematoxylin-eosin (HE) staining. It was found that the depression-like behavior, spatial memory ability and histology of the brain did not change obviously after RF exposure. However, the anxiety-like behavior increased in mice, while, the levels of γ-aminobutyric acid (GABA) and aspartic acid (Asp) in cortex and hippocampus significantly decreased after RF exposure. These data suggested that RF exposure under these conditions do not affect the depression-like behavior, spatial memory and brain histology in adolescent male mice, but it may however increase the level of anxiety, and GABA and Asp were probably involved in this effect.

Suggested Citation

  • Jun-Ping Zhang & Ke-Ying Zhang & Ling Guo & Qi-Liang Chen & Peng Gao & Tian Wang & Jing Li & Guo-Zhen Guo & Gui-Rong Ding, 2017. "Effects of 1.8 GHz Radiofrequency Fields on the Emotional Behavior and Spatial Memory of Adolescent Mice," IJERPH, MDPI, vol. 14(11), pages 1-14, November.
  • Handle: RePEc:gam:jijerp:v:14:y:2017:i:11:p:1344-:d:117670
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    References listed on IDEAS

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    1. Andreas Meyer-Lindenberg, 2010. "Genes and the anxious brain," Nature, Nature, vol. 466(7308), pages 827-828, August.
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    Cited by:

    1. Dan-Yang Li & Jing-Dong Song & Zhao-Yuan Liang & Kiana Oskouei & Xiang-Qian Xiao & Wen-Zhe Hou & Jin-Tao Li & Yi-Shu Yang & Ming-Lian Wang & Manuel Murbach, 2020. "Apoptotic Effect of 1800 MHz Electromagnetic Radiation on NIH/3T3 Cells," IJERPH, MDPI, vol. 17(3), pages 1-11, January.
    2. Zenon Sienkiewicz & Eric van Rongen, 2019. "Can Low-Level Exposure to Radiofrequency Fields Effect Cognitive Behaviour in Laboratory Animals? A Systematic Review of the Literature Related to Spatial Learning and Place Memory," IJERPH, MDPI, vol. 16(9), pages 1-23, May.

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