IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v14y2017i10p1282-d116277.html
   My bibliography  Save this article

Endocrine Disruptors Leading to Obesity and Related Diseases

Author

Listed:
  • Demetrios Petrakis

    (Department of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, 71003 Heraklion, Crete, Greece
    These authors contributed equally to this work.)

  • Loukia Vassilopoulou

    (Department of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, 71003 Heraklion, Crete, Greece
    These authors contributed equally to this work.)

  • Charalampos Mamoulakis

    (Department of Urology, University General Hospital of Heraklion, Medical School, University of Crete, 71003 Heraklion, Crete, Greece
    These authors contributed equally to this work.)

  • Christos Psycharakis

    (Department of Obstetrics and Gynecology, Venizeleio—Pananio General Hospital of Heraklion, 71409 Heraklion, Crete, Greece)

  • Aliki Anifantaki

    (Crete Fertility Center, 56, Arch. Makariou & Sof. Venizelou Str., 71202 Heraklion, Crete, Greece)

  • Stavros Sifakis

    (Mitera Hospital, 71409 Heraklion, Crete, Greece)

  • Anca Oana Docea

    (Department of Toxicology, Faculty of Pharmacy, University of Medicine and Pharmacy, Petru Rares, 200349 Craiova, Romania)

  • John Tsiaoussis

    (Laboratory of Anatomy-Histology-Embryology, Medical School, University of Crete, 71003 Heraklion, Crete, Greece)

  • Antonios Makrigiannakis

    (Department of Obstetrics and Gynecology, Medical School, University of Crete, 71003 Heraklion, Crete, Greece)

  • Aristides M. Tsatsakis

    (Department of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, 71003 Heraklion, Crete, Greece)

Abstract

The review aims to comprehensively present the impact of exposure to endocrine disruptors (EDs) in relation to the clinical manifestation of obesity and related diseases, including diabetes mellitus, metabolic syndrome, cardiovascular diseases, carcinogenesis and infertility. EDs are strong participants in the obesity epidemic scenery by interfering with cellular morphological and biochemical processes; by inducing inflammatory responses; and by presenting transcriptional and oncogenic activity. Obesity and lipotoxicity enhancement occur through reprogramming and/or remodeling of germline epigenome by exposure to EDs. Specific population groups are vulnerable to ED exposure due to current dietary and environmental conditions. Obesity, morbidity and carcinogenicity induced by ED exposure are an evolving reality. Therefore, a new collective strategic approach is deemed essential, for the reappraisal of current global conditions pertaining to energy management.

Suggested Citation

  • Demetrios Petrakis & Loukia Vassilopoulou & Charalampos Mamoulakis & Christos Psycharakis & Aliki Anifantaki & Stavros Sifakis & Anca Oana Docea & John Tsiaoussis & Antonios Makrigiannakis & Aristides, 2017. "Endocrine Disruptors Leading to Obesity and Related Diseases," IJERPH, MDPI, vol. 14(10), pages 1-18, October.
    • Handle: RePEc:gam:jijerp:v:14:y:2017:i:10:p:1282-:d:116277
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/14/10/1282/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/14/10/1282/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Till Strowig & Jorge Henao-Mejia & Eran Elinav & Richard Flavell, 2012. "Inflammasomes in health and disease," Nature, Nature, vol. 481(7381), pages 278-286, January.
    2. Emma L Anderson & Laura D Howe & Hayley E Jones & Julian P T Higgins & Debbie A Lawlor & Abigail Fraser, 2015. "The Prevalence of Non-Alcoholic Fatty Liver Disease in Children and Adolescents: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(10), pages 1-14, October.
    3. Qin Yang & Timothy E. Graham & Nimesh Mody & Frederic Preitner & Odile D. Peroni & Janice M. Zabolotny & Ko Kotani & Loredana Quadro & Barbara B. Kahn, 2005. "Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes," Nature, Nature, vol. 436(7049), pages 356-362, July.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Jong-Joo Kim & Surendra Kumar & Vinay Kumar & Yun-Mi Lee & You-Sam Kim & Vijay Kumar, 2019. "Bisphenols as a Legacy Pollutant, and Their Effects on Organ Vulnerability," IJERPH, MDPI, vol. 17(1), pages 1-18, December.
    2. Saira Amir & Syed Tahir Abbas Shah & Charalampos Mamoulakis & Anca Oana Docea & Olga-Ioanna Kalantzi & Athanasios Zachariou & Daniela Calina & Felix Carvalho & Nikolaos Sofikitis & Antonios Makrigiann, 2021. "Endocrine Disruptors Acting on Estrogen and Androgen Pathways Cause Reproductive Disorders through Multiple Mechanisms: A Review," IJERPH, MDPI, vol. 18(4), pages 1-20, February.
    3. Jose L. García-Soidán & Raquel Leirós-Rodríguez & Vicente Romo-Pérez & Víctor Arufe-Giráldez, 2020. "Evolution of the Habits of Physical Activity and Television Viewing in Spanish Children and Pre-Adolescents between 1997 and 2017," IJERPH, MDPI, vol. 17(18), pages 1-13, September.
    4. Monica Lopes-Ferreira & Adolfo Luis Almeida Maleski & Leticia Balan-Lima & Jefferson Thiago Gonçalves Bernardo & Lucas Marques Hipolito & Ana Carolina Seni-Silva & Joao Batista-Filho & Maria Alice Pim, 2022. "Impact of Pesticides on Human Health in the Last Six Years in Brazil," IJERPH, MDPI, vol. 19(6), pages 1-19, March.
    5. Denisa Margină & Anca Ungurianu & Carmen Purdel & Dimitris Tsoukalas & Evangelia Sarandi & Maria Thanasoula & Fotios Tekos & Robin Mesnage & Demetrios Kouretas & Aristidis Tsatsakis, 2020. "Chronic Inflammation in the Context of Everyday Life: Dietary Changes as Mitigating Factors," IJERPH, MDPI, vol. 17(11), pages 1-27, June.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Cecilia Pessoa Rodrigues & Aindrila Chatterjee & Meike Wiese & Thomas Stehle & Witold Szymanski & Maria Shvedunova & Asifa Akhtar, 2021. "Histone H4 lysine 16 acetylation controls central carbon metabolism and diet-induced obesity in mice," Nature Communications, Nature, vol. 12(1), pages 1-21, December.
    2. Peige Song & Jinyue Yu & Manli Wang & Xinlei Chang & Jiawen Wang & Lin An, 2017. "Prevalence and Correlates of Suspected Nonalcoholic Fatty Liver Disease in Chinese Children," IJERPH, MDPI, vol. 14(5), pages 1-10, April.
    3. Yu Zou & Da-Hong Wang & Noriko Sakano & Yoshie Sato & Suketaka Iwanaga & Kazuhisa Taketa & Masayuki Kubo & Kei Takemoto & Chie Masatomi & Kiyomi Inoue & Keiki Ogino, 2014. "Associations of Serum Retinol, α-Tocopherol, and γ-Tocopherol with Biomarkers among Healthy Japanese Men," IJERPH, MDPI, vol. 11(2), pages 1-14, January.
    4. Konxhe Kulaj & Alexandra Harger & Michaela Bauer & Özüm S. Caliskan & Tilak Kumar Gupta & Dapi Menglin Chiang & Edward Milbank & Josefine Reber & Angelos Karlas & Petra Kotzbeck & David N. Sailer & Fr, 2023. "Adipocyte-derived extracellular vesicles increase insulin secretion through transport of insulinotropic protein cargo," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    5. Jonathan M. Dreyfuss & Yixing Yuchi & Xuehong Dong & Vissarion Efthymiou & Hui Pan & Donald C. Simonson & Ashley Vernon & Florencia Halperin & Pratik Aryal & Anish Konkar & Yinong Sebastian & Brandon , 2021. "High-throughput mediation analysis of human proteome and metabolome identifies mediators of post-bariatric surgical diabetes control," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    6. Wendy N. Phoswa & Olive P. Khaliq & Simeon Eche, 2023. "A Review on Inflammasomes and Immune Checkpoints in Pre-Eclampsia Complicated with Tuberculosis and Human Immune Deficiency Virus," IJERPH, MDPI, vol. 20(17), pages 1-15, August.
    7. Tina Rönn & Jones K. Ofori & Alexander Perfilyev & Alexander Hamilton & Karolina Pircs & Fabian Eichelmann & Sonia Garcia-Calzon & Alexandros Karagiannopoulos & Hans Stenlund & Anna Wendt & Petr Volko, 2023. "Genes with epigenetic alterations in human pancreatic islets impact mitochondrial function, insulin secretion, and type 2 diabetes," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    8. Lidwina Priliani & Sukma Oktavianthi & Elizabeth L Prado & Safarina G Malik & Anuraj H Shankar, 2020. "Maternal biomarker patterns for metabolism and inflammation in pregnancy are influenced by multiple micronutrient supplementation and associated with child biomarker patterns and nutritional status at," PLOS ONE, Public Library of Science, vol. 15(8), pages 1-21, August.
    9. Shin-ichi Hirano & Yusuke Ichikawa & Bunpei Sato & Fumitake Satoh & Yoshiyasu Takefuji, 2020. "Hydrogen Is Promising for Medical Applications," Clean Technol., MDPI, vol. 2(4), pages 1-13, December.
    10. Federica Catalano & Francesca De Vito & Velia Cassano & Teresa Vanessa Fiorentino & Angela Sciacqua & Marta Letizia Hribal, 2022. "Circadian Clock Desynchronization and Insulin Resistance," IJERPH, MDPI, vol. 20(1), pages 1-11, December.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:14:y:2017:i:10:p:1282-:d:116277. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.