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Joint Toxicity of Different Heavy Metal Mixtures after a Short-Term Oral Repeated-Administration in Rats

Author

Listed:
  • Hong Su

    (Department of Preventative Medicine, Zhejiang Key Laboratory of Pathophysiology, Medicine School of Ningbo University, 818 Fenghua Road, Ningbo 315211, Zhejiang, China
    These authors contributed equally to this work.)

  • Zhou Li

    (Department of Preventative Medicine, Zhejiang Key Laboratory of Pathophysiology, Medicine School of Ningbo University, 818 Fenghua Road, Ningbo 315211, Zhejiang, China
    These authors contributed equally to this work.)

  • Samuel Selorm Fiati Kenston

    (Department of Preventative Medicine, Zhejiang Key Laboratory of Pathophysiology, Medicine School of Ningbo University, 818 Fenghua Road, Ningbo 315211, Zhejiang, China
    These authors contributed equally to this work.)

  • Hongbo Shi

    (Ningbo Municipal Center for Disease Control and Prevention, Ningbo 315010, Zhejiang, China)

  • Yafei Wang

    (Department of Preventative Medicine, Zhejiang Key Laboratory of Pathophysiology, Medicine School of Ningbo University, 818 Fenghua Road, Ningbo 315211, Zhejiang, China)

  • Xin Song

    (Department of Preventative Medicine, Zhejiang Key Laboratory of Pathophysiology, Medicine School of Ningbo University, 818 Fenghua Road, Ningbo 315211, Zhejiang, China)

  • Yuanliang Gu

    (Department of Preventative Medicine, Zhejiang Key Laboratory of Pathophysiology, Medicine School of Ningbo University, 818 Fenghua Road, Ningbo 315211, Zhejiang, China)

  • Tabatha Barber

    (Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA)

  • Joni Aldinger

    (Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA)

  • Baobo Zou

    (Department of Preventative Medicine, Zhejiang Key Laboratory of Pathophysiology, Medicine School of Ningbo University, 818 Fenghua Road, Ningbo 315211, Zhejiang, China)

  • Min Ding

    (Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA)

  • Jinshun Zhao

    (Department of Preventative Medicine, Zhejiang Key Laboratory of Pathophysiology, Medicine School of Ningbo University, 818 Fenghua Road, Ningbo 315211, Zhejiang, China
    Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA)

  • Xialu Lin

    (Department of Preventative Medicine, Zhejiang Key Laboratory of Pathophysiology, Medicine School of Ningbo University, 818 Fenghua Road, Ningbo 315211, Zhejiang, China
    School of Public Health, Key Laboratory of Environment and Gene Related Diseases of Ministry of Education, Health Science Center, Xi’an Jiaotong University, Xi’an 710049, Shaanxi, China)

Abstract

The systemic toxicity of different combinations of heavy metal mixtures (HMMs) was studied according to equivalent proportions of the eight most common detectable heavy metals found in fish consumption in the Ningbo area of China. The ion mass proportions of Zn, Cu, Mn, Cr, Ni, Cd, Pb, and Hg were 1070.0, 312.6, 173.1, 82.6, 30.0, 13.3, 6.6, and 1.0, respectively. In this study, 10 experimental groups were set as follows: M8 (Pb + Cd + Hg + Ni + Cu + Zn + Mn + Cr); M5 (Pb + Cd + Hg + Ni + Cr); M4A (Pb + Cd + Hg + Ni); M4B (Cu + Zn + Mn + Cr); M3 (Cu + Zn + Mn); Cr; Cu; Zn; Mn; and control. Sprague Dawley (SD) rats were orally treated with a single dose of each group every three days (10 times in total) for 34 days. After Morris water maze test, blood and tissue samples were collected to obtain biochemical, histopathological and western blot analysis. Results show abnormalities could be observed in different treatment groups, the M4B combination had the most significant change compared to all other groups. In conclusion, combination HMMs may have adverse effects on the hematologic, hepatic, renal and neurobehavioral function, and may also disturb electrolyte and lipid balance. Why M4B combination generated much higher toxic effects than any other combination mixtures or individual heavy metal needs to be further evaluated.

Suggested Citation

  • Hong Su & Zhou Li & Samuel Selorm Fiati Kenston & Hongbo Shi & Yafei Wang & Xin Song & Yuanliang Gu & Tabatha Barber & Joni Aldinger & Baobo Zou & Min Ding & Jinshun Zhao & Xialu Lin, 2017. "Joint Toxicity of Different Heavy Metal Mixtures after a Short-Term Oral Repeated-Administration in Rats," IJERPH, MDPI, vol. 14(10), pages 1-18, October.
    • Handle: RePEc:gam:jijerp:v:14:y:2017:i:10:p:1164-:d:113894
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    Cited by:

    1. Zhou Li & Hong Su & Li Wang & Danbiao Hu & Lijun Zhang & Jian Fang & Micong Jin & Samuel Selorm Fiati Kenston & Xin Song & Hongbo Shi & Jinshun Zhao & Guochuan Mao, 2018. "Epidemiological Study on Metal Pollution of Ningbo in China," IJERPH, MDPI, vol. 15(3), pages 1-14, February.

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