IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v13y2016i9p918-d78249.html
   My bibliography  Save this article

Antibiotic Resistance of Bacteria Involved in Urinary Infections in Brazil: A Cross-Sectional and Retrospective Study

Author

Listed:
  • Wellington Francisco Rodrigues

    (Postgraduate Course in Health Sciences, Federal University of Triângulo Mineiro, 38061-500 Uberaba, MG, Brazil
    Institute of Genetics and Biochemistry, Federal University of Uberlandia, 38400-902 Uberlandia, MG, Brazil
    Faculty Morgana Potrich—FAMP, 75830-000 Mineiros, GO, Brazil)

  • Camila Botelho Miguel

    (Postgraduate Course in Health Sciences, Federal University of Triângulo Mineiro, 38061-500 Uberaba, MG, Brazil)

  • Ana Paula Oliveira Nogueira

    (Institute of Genetics and Biochemistry, Federal University of Uberlandia, 38400-902 Uberlandia, MG, Brazil)

  • Carlos Ueira-Vieira

    (Institute of Genetics and Biochemistry, Federal University of Uberlandia, 38400-902 Uberlandia, MG, Brazil)

  • Tony De Paiva Paulino

    (Laboratório de Pesquisas do Cefores, Universidade Federal do Triângulo Mineiro, 38015-050 Uberaba, MG, Brazil)

  • Siomar De Castro Soares

    (Institute of Biological and Natural Sciences, Federal University of Triângulo Mineiro, 38015-050 Uberaba, MG, Brazil)

  • Elisabete Aparecida Mantovani Rodrigues De Resende

    (Clinical Hospital, Division of Endocrinology, Federal University of Triângulo Mineiro, 38025-180 Uberaba, MG, Brazil)

  • Javier Emilio Lazo-Chica

    (Postgraduate Course in Health Sciences, Federal University of Triângulo Mineiro, 38061-500 Uberaba, MG, Brazil
    Institute of Biological and Natural Sciences, Federal University of Triângulo Mineiro, 38015-050 Uberaba, MG, Brazil)

  • Marcelo Costa Araújo

    (Clinical Pathology Service, Microbiology, Federal University of Triângulo Mineiro, 38025-180 Uberaba, MG, Brazil)

  • Carlo José Oliveira

    (Institute of Biological and Natural Sciences, Federal University of Triângulo Mineiro, 38015-050 Uberaba, MG, Brazil)

Abstract

Empirical and prolonged antimicrobial treatment of urinary tract infections caused by Escherichia coli is associated with the emergence of bacterial resistance, and not all countries have strict policies against the indiscriminate use of drugs in order to prevent resistance. This cross-sectional and retrospective study (2010–2015) aimed to evaluate the sensitivity and resistance of patient-derived E. coli to different drugs broadly used to treat urinary infections in Brazil: ampicillin + sulbactam, cephalothin, ciprofloxacin, norfloxacin, and nitrofurantoin. We obtained 1654 E. coli samples from ambulatory patients with disease symptoms of the urinary tract from a Brazilian public hospital. While all antibiotics were effective in killing E. coli to a large degree, nitrofurantoin was the most effective, with fewer samples exhibiting antibiotic resistance. We assessed the costs of generic and brand name versions of each antibiotic. Nitrofurantoin, the most effective antibiotic, was the cheapest, followed by the fluoroquinolones (ciprofloxacin and norfloxacin), ampicillin + sulbactam and, lastly, cephalothin. Finally, assessment of antibiotic resistance to fluoroquinolones over the study period and extrapolation of the data led to the conclusion that these antibiotics could no longer be effective against E. coli -based urinary infections in approximately 20 years if their indiscriminate use in empirical treatment continues.

Suggested Citation

  • Wellington Francisco Rodrigues & Camila Botelho Miguel & Ana Paula Oliveira Nogueira & Carlos Ueira-Vieira & Tony De Paiva Paulino & Siomar De Castro Soares & Elisabete Aparecida Mantovani Rodrigues D, 2016. "Antibiotic Resistance of Bacteria Involved in Urinary Infections in Brazil: A Cross-Sectional and Retrospective Study," IJERPH, MDPI, vol. 13(9), pages 1-10, September.
    • Handle: RePEc:gam:jijerp:v:13:y:2016:i:9:p:918-:d:78249
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/13/9/918/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/13/9/918/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Nerino Allocati & Michele Masulli & Mikhail F. Alexeyev & Carmine Di Ilio, 2013. "Escherichia coli in Europe: An Overview," IJERPH, MDPI, vol. 10(12), pages 1-20, November.
    2. Christopher F. Higgins, 2007. "Multiple molecular mechanisms for multidrug resistance transporters," Nature, Nature, vol. 446(7137), pages 749-757, April.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Nikolett Orosz & Tünde Tóthné Tóth & Gyöngyi Vargáné Gyuró & Zsoltné Tibor Nábrádi & Klára Hegedűsné Sorosi & Zsuzsa Nagy & Éva Rigó & Ádám Kaposi & Gabriella Gömöri & Cornelia Melinda Adi Santoso & A, 2022. "Comparison of Length of Hospital Stay for Community-Acquired Infections Due to Enteric Pathogens, Influenza Viruses and Multidrug-Resistant Bacteria: A Cross-Sectional Study in Hungary," IJERPH, MDPI, vol. 19(23), pages 1-16, November.
    2. Alexander A. Shcherbakov & Peyton J. Spreacker & Aurelio J. Dregni & Katherine A. Henzler-Wildman & Mei Hong, 2022. "High-pH structure of EmrE reveals the mechanism of proton-coupled substrate transport," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    3. Miquel Serra-Burriel & Matthew Keys & Carlos Campillo-Artero & Antonella Agodi & Martina Barchitta & Achilleas Gikas & Carlos Palos & Guillem López-Casasnovas, 2020. "Impact of multi-drug resistant bacteria on economic and clinical outcomes of healthcare-associated infections in adults: Systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 15(1), pages 1-14, January.
    4. Erika Pavez-Muñoz & Bastián Fernández-Sanhueza & Constanza Urzúa-Encina & Nicolás Galarce & Raúl Alegría-Morán, 2021. "Risk Factors for Positivity to Shiga Toxin-Producing Escherichia coli and Salmonella enterica in Backyard Production Systems Animals from Metropolitana Region, Chile: A Threat to Public Health?," IJERPH, MDPI, vol. 18(20), pages 1-16, October.
    5. Valery Silvery Sonola & Abdul Katakweba & Gerald Misinzo & Mecky Isaac Matee, 2022. "Molecular Epidemiology of Antibiotic Resistance Genes and Virulence Factors in Multidrug-Resistant Escherichia coli Isolated from Rodents, Humans, Chicken, and Household Soils in Karatu, Northern Tanz," IJERPH, MDPI, vol. 19(9), pages 1-13, April.
    6. Jody L. Andersen & Gui-Xin He & Prathusha Kakarla & Ranjana KC & Sanath Kumar & Wazir Singh Lakra & Mun Mun Mukherjee & Indrika Ranaweera & Ugina Shrestha & Thuy Tran & Manuel F. Varela, 2015. "Multidrug Efflux Pumps from Enterobacteriaceae, Vibrio cholerae and Staphylococcus aureus Bacterial Food Pathogens," IJERPH, MDPI, vol. 12(2), pages 1-61, January.
    7. Niklas Pleger & Beatrix Kloft & David Quarcoo & Simona Zitnik & Stefanie Mache & Doris Klingelhoefer & David A Groneberg, 2014. "Bacterial Meningitis: A Density-Equalizing Mapping Analysis of the Global Research Architecture," IJERPH, MDPI, vol. 11(10), pages 1-13, September.
    8. Paola Duque-Sarango & Leonardo Romero-Martínez & Verónica Pinos-Vélez & Esteban Sánchez-Cordero & Esteban Samaniego, 2023. "Comparative Study of UV Radiation Resistance and Reactivation Characteristics of E. coli ATCC 8739 and Native Strains: Implications for Water Disinfection," Sustainability, MDPI, vol. 15(12), pages 1-12, June.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:13:y:2016:i:9:p:918-:d:78249. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.