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Coarse Fraction Particle Matter and Exhaled Nitric Oxide in Non-Asthmatic Children

Author

Listed:
  • Hanne Krage Carlsen

    (Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine, University of Umeå, Umeå 90187, Sweden
    Section of Occupational and Environmental Medicine, Department of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg 40530, Sweden
    Centre of Public Health, University of Iceland, Reykjavík 101, Iceland)

  • Peter Boman

    (Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine, University of Umeå, Umeå 90187, Sweden)

  • Bodil Björ

    (Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine, University of Umeå, Umeå 90187, Sweden)

  • Anna-Carin Olin

    (Section of Occupational and Environmental Medicine, Department of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg 40530, Sweden)

  • Bertil Forsberg

    (Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine, University of Umeå, Umeå 90187, Sweden)

Abstract

Coarse particle matter, PM coarse , is associated with increased respiratory morbidity and mortality. The aim of this study was to investigate the association between short-term changes in PM coarse and sub-clininal airway inflammation in children. Healthy children aged 11 years from two northern Swedish elementary schools underwent fraction of exhaled nitrogen oxide (FENO) measurements to determine levels of airway inflammation twice weekly during the study period from 11 April–6 June 2011. Daily exposure to PM coarse , PM 2.5 , NO 2 , NOx, NO and O 3 and birch pollen was estimated. Multiple linear regression was used. Personal covariates were included as fixed effects and subjects were included as a random effect. In total, 95 children participated in the study, and in all 493 FENO measurements were made. The mean level of PM coarse was 16.1 μg/m 3 (range 4.1–42.3), and that of O 3 was 75.0 μg/m 3 (range: 51.3–106.3). That of NO 2 was 17.0 μg/m 3 (range: 4.7–31.3), NOx was 82.1 μg/m 3 (range: 13.3–165.3), and NO was 65 μg/m 3 (range: 8.7–138.4) during the study period. In multi-pollutant models an interquartile range increase in 24 h PM coarse was associated with increases in FENO by between 6.9 ppb (95% confidence interval 0.0–14) and 7.3 ppb (95% confidence interval 0.4–14.9). PM coarse was associated with an increase in FENO, indicating sub-clinical airway inflammation in healthy children.

Suggested Citation

  • Hanne Krage Carlsen & Peter Boman & Bodil Björ & Anna-Carin Olin & Bertil Forsberg, 2016. "Coarse Fraction Particle Matter and Exhaled Nitric Oxide in Non-Asthmatic Children," IJERPH, MDPI, vol. 13(6), pages 1-11, June.
    • Handle: RePEc:gam:jijerp:v:13:y:2016:i:6:p:621-:d:72503
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    Citations

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    Cited by:

    1. Khairul Nizam Mohd Isa & Zailina Hashim & Juliana Jalaludin & Leslie Thian Lung Than & Jamal Hisham Hashim, 2020. "The Effects of Indoor Pollutants Exposure on Allergy and Lung Inflammation: An Activation State of Neutrophils and Eosinophils in Sputum," IJERPH, MDPI, vol. 17(15), pages 1-18, July.
    2. Khairul Nizam Mohd Isa & Juliana Jalaludin & Saliza Mohd Elias & Norlen Mohamed & Jamal Hisham Hashim & Zailina Hashim, 2022. "Evaluation of the Relationship between Fractional Exhaled Nitric Oxide (FeNO) with Indoor PM 10 , PM 2.5 and NO 2 in Suburban and Urban Schools," IJERPH, MDPI, vol. 19(8), pages 1-12, April.

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