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The Effect of Seasonal Variations in Airborne Particulate Matter on Asthma-Related Airway Inflammation in Mice

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  • Jun Kurai

    (Department of Respiratory Medicine and Rheumatology, Faculty of Medicine, Tottori University, 36-1 Nishi-cho, Yonago 683-8504, Japan)

  • Masanari Watanabe

    (Department of Respiratory Medicine and Rheumatology, Faculty of Medicine, Tottori University, 36-1 Nishi-cho, Yonago 683-8504, Japan)

  • Hiroyuki Sano

    (Department of Respiratory Medicine and Allergology, Faculty of Medicine, Kinki University, 377-2 Ohnohigashi, Osakasayama 589-0014, Japan)

  • Degejirihu Hantan

    (Department of Respiratory Medicine and Rheumatology, Faculty of Medicine, Tottori University, 36-1 Nishi-cho, Yonago 683-8504, Japan)

  • Eiji Shimizu

    (Department of Respiratory Medicine and Rheumatology, Faculty of Medicine, Tottori University, 36-1 Nishi-cho, Yonago 683-8504, Japan)

Abstract

This study aimed to investigate the effects of winter and spring particulate matter (PM) on airway inflammation and allergies in a mouse asthma model. PM was collected during 7–28 February 2013 (winter) and during 7–28 April 2013 (spring) in Yonago, Japan. NC/Nga mice were co-sensitized using intranasal instillation of the PMs and Dermatophagoides farinae (Df) for 5 consecutive days, and were subsequently challenged using intranasal Df at 7 days after the last sensitization. At 24 h after the challenge, serum immunoglobulin levels, differential leukocyte counts, and inflammatory cytokines levels were measured in the mice’s bronchoalveolar lavage fluid (BALF). Compared to co-sensitization using spring PM and Df, winter PM and Df induced greater increases in the BALF neutrophil and eosinophil counts and total serum IgE and IgG2a levels. Furthermore, winter PM-sensitized mice exhibited higher BALF levels of interleukin-5, interleukin-13, interleukin-6, and keratinocyte-derived chemokine. Therefore, we observed seasonal variations in the effects of PM on asthma-related airway inflammation. These findings suggest that the compositions of PM vary according to season, and that it is important to evaluate PM compositions in order to understand the associations between asthma and PM.

Suggested Citation

  • Jun Kurai & Masanari Watanabe & Hiroyuki Sano & Degejirihu Hantan & Eiji Shimizu, 2016. "The Effect of Seasonal Variations in Airborne Particulate Matter on Asthma-Related Airway Inflammation in Mice," IJERPH, MDPI, vol. 13(6), pages 1-10, June.
    • Handle: RePEc:gam:jijerp:v:13:y:2016:i:6:p:579-:d:71773
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    References listed on IDEAS

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    1. Yuan Wang & Renyi Zhang & R. Saravanan, 2014. "Asian pollution climatically modulates mid-latitude cyclones following hierarchical modelling and observational analysis," Nature Communications, Nature, vol. 5(1), pages 1-7, May.
    2. Masanari Watanabe & Hisashi Noma & Jun Kurai & Hiroyuki Sano & Hiroya Kitano & Rumiko Saito & Yutaka Kimura & Setsuya Aiba & Mitsuo Oshimura & Eiji Shimizu, 2015. "Variation in the Effect of Particulate Matter on Pulmonary Function in Schoolchildren in Western Japan and Its Relation with Interleukin-8," IJERPH, MDPI, vol. 12(11), pages 1-15, November.
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    Cited by:

    1. Jun Kurai & Masanari Watanabe & Hiroyuki Sano & Kyoko Iwata & Degejirihu Hantan & Eiji Shimizu, 2018. "A Muscarinic Antagonist Reduces Airway Inflammation and Bronchoconstriction Induced by Ambient Particulate Matter in a Mouse Model of Asthma," IJERPH, MDPI, vol. 15(6), pages 1-15, June.

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